I.P. Butkevich - Dr. Sc. (Biol.), Leading Research Scientist, I.P. Pavlov Institute of Physiology, RAS (St.-Petersburg). E-mail: irinabutkevich@yandex.ru; V.A. Mikhailenko - Ph.D. (Biol.), Senior Research Scientist, I.P. Pavlov Institute of Physiology, RAS (St.-Petersburg). E-mail: viktormikhailenko@yandex.ru

The aim of the work was to study the effects of long-term influences of pain caused by inflammation or maternal separation stress at different terms of the neonatal period (in the first and repeatedly in second days of life or in the seventh and repeatedly in eighth days of life) on adaptive behavior in rats of both sexes in adolescent period (25-35 days) or in adults (90...100 days). The functional state of the nociceptive system in the hot plate test and in conditions of re-inflammatory pain in the formalin test was evaluated, the level of anxiety in the elevated plus maze test, the level of depression-like behavior in the forced swim test and the ability to develop a spatial differentiation in the maze Morris were evaluated as well. The data obtained allow us to make the following conclusion. Stress of maternal separation only in premature infants causes long-term hyperalgesia; early pain in the presence of the mother causes a long-term hyperalgesia only in males. The direction of effects of early impacts on the adaptive behavior in other behavioral tests is similar in adolescent and adult rats. Thus, the long-term consequences of stress impacts during early age on adaptive behavior have been found. Dependence of these effects on the term of neonatal impact, its type and subject-s sex has been revealed. The study was supported by RFBR project N 14-04-00106a.

 

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