M.V. Shayhelislamova - Dr.Sc. (Biol.), Professor, Department of Anatomy, Physiology and Human Health, Kazan (Volga Region) Federal University (Kazan). E-mail: bettydn@mail.ru N.B. Dikopolskaya - Ph.D. (Biol), Associate Professor, Department of Anatomy, Physiology and Human Health, Kazan (Volga Region) Federal University (Kazan). E-mail: bettydn@mail.ru G.A. Bilalova - Ph.D. (Biol), Associate Professor, Department of Anatomy, Physiology and Human Health, Kazan (Volga Region) Federal University (Kazan). E-mail: g.bilalova@mai.ru

Age development and adaptive activity of 715 year-old children is provided by sympathoadrenal system (SAS) and the adrenal cortex (AC) complex interdependent reactions aimed at meeting growing body\'s metabolic and adaptation needs. Taking into account that the puberty period neuroendocrine system development is mainly determined by the level of sexual maturity, the study of the SAS and AC functional state was carried out at each puberty stage which assessed at the level of adrenaline (A), noradrenaline (NA), dopamine (DA), DHPA as well as 17-oxicorticosteroids (17-OKS) and 17-ketosteroids (17-KS) excretion in the daily urine. Starting from the first up to the third stages unidirectional and positive shifts of the studied parameters in both sex groups are observed. This may indicate the functional interconnection between SAS and AC, their synergistic biological effect at the gonad activation stage. At the fourth puberty stage, characterized by adrenal cortex and gonad intensive formation, sex group pecularities are revealed: the boys show a significant increase in 17-KS and 17-GCC (p <0.05), combined with an even greater increase in NA excretion providing, probably along with other central nervous system mediators, nerve humoral transmission effects at hypothalamus level, and as a result, AC activation. The girls show the indicators stabilization at a lower A excretion. At the fifth puberty stage the studied parameters dynamics in both sex groups is different: the daily NA excretion is reduced at a stable A level, and 17-KS and 17-OKS excretion keeps growing substantially. This indicates incomplete pubertal AC formation among the children studied, and it\'s consistent with the literature data of the later pubertal changes in the pituitary-adrenal system regulation, when the definitive level of cortisol and dehydroepiandrosterone consentration is formed only by 21.

 

1. SHajjkhelislamova M.V., Dikopolskaja N.B., Kajumova G.G.Gormonalnye mekhanizmy reguljacii myshechnojj dejatelnosti podrostkov // Nejjrokompjutery: razrabotka i primenenie. 2015. № 1. S. 4348.
2. Lebenthal Y.,CatYablonski G., Shtaif B. Effect of sex hormone administration on circulating ghrelin levels in peripubertal children // J. Clinic / Endocrinol. Metabolism. 2006. V. 91. № 1. P. 328-331.
3. Reineher T.,Sousa G., Ludwig Roth C.Androgens before and after weight loss in obese children // J. Clinic / Endocrinol. Metabolism. 2005. V. 90. № 10. P. 5588-5595.
4. McCartney C.R.,Blank S.K., Prendergast K.A. et. al.Obesity and sex steroid changes across puberty evidence for market hyperandrogenemia in pre- and early pubertal obese girls // Clin. Endocrinol. Metab. 2007. V. 92. № 2. P. 430436.