F.G. Sitdikov - Dr.Sc. (Biol.), Professor, Department of Anatomy, Physiology and Human Health, Kazan (Volga Region) Federal University (Kazan). E-mail: fgsitdikov@mail.ru A.R. Gissatullin - Ph.D. (Biol), Associate Professor, Department of Anatomy, Physiology and Human Health, Kazan (Volga Region) Federal University (Kazan). E-mail: almaz-giz@rambler.ru R.R. Minnachmetov - Ph.D. (Biol), Associate Professor, Department of Anatomy, Physiology and Human Health, Kazan (Volga Region) Federal University (Kazan). E-mail: Minnakhmetov@mail.ru G.A. Bilalova - Ph.D. (Biol), Associate Professor, Department of Anatomy, Physiology and Human Health, Kazan (Volga Region) Federal University (Kazan). E-mail: g.bilalova@mai.ru N.B. Dikopolskaya - Ph.D. (Biol), Associate Professor, Department of Anatomy, Physiology and Human Health, Kazan (Volga Region) Federal University (Kazan). E-mail: bettydn@mail.ru

Studied the formation of the relationship of sympathetic and parasympathetic influences on the heart in dogs and rats in ontogenesis during electrical stimulation of nerves. In adult animals, the basic principle of their relationship - mutual compensatory activity at both parts of the nervous system. The mutual compensatory principle develops gradually as the maturation of sympathetic and parasympathetic influences on the heart. By increasing the activity of the sympathetic nervous system of compensatory increase in the influence of parasympathetic part protects the heart from overload. All of this has been proven in experiments on growing animals (dogs, rats) in the study of the phenomenon of \"escape the heart,\" adaptation to sympathetic influences, as model experiments of physical activity, in a vagotomy and sympathectomy. Studies were conducted on the puppies first, second, third, age groups and adult dogs with dissection postganglionic fibers with artificial respiration. Sympathectomy in rats of different ages held guanethidine sulfate solution. We determined the effect of sympathectomy on the effects of electrical stimulation of the vagus nerves. Puppies - period of adaptation to the sympathetic impact was longer because of the immaturity of compensatory effects of parasympathetic nerves. Right-sided stimulation of the vagus nerve in sempathectomised animals caused mainly reduction of heart rate, increased cardiac output was less pronounced. Starting from 70-day-old, right-sided stimulation causes only changes in heart rate. Upon stimulation of the left vagus nerve, starting from 70 days of age, there is a negative inotropic response. Consequently, the asymmetry is generated in the influence of the vagus nerves on the heart.

 

1. Sitdikov F.G., Gilmutdinova R.I., Minnakhmetov R.R., Gizzatullin A.R. Vlijanie ehlektricheskojj stimuljacii bluzhdajushhikh nervov na dejatelnost serdca desimpatizirovannykh krys v postnatalnom ontogeneze // Bjulleten ehksperimentalnojj biologii i mediciny. 2003. T. 135. № 6. S. 626-628.
2. Hakim K., Fisher M., Gunnicker M. et al. Functional Role of β2-Adrenoceptors in the Transplanted Human Heart // J. Cardiovase. Pharmacol. 1997. V. 30. № 6. P. 811-816.
3. Roeske W.R., Wildenthal K. Responsiveness to drugs and hormones in the murine model of cardiac ontogenesis // Pharmacol. & Therapeutics. 1981. V. 14. P. 55-66.
4. Bilalova G.A., Anikina T.A., Sitdikov F.G. Vozrastnye osobennosti udarnogo obema krovi krys na stimuljaciju simpaticheskogo ganglija posle blokady β-adrenoreceptorov // Bjulleten ehksperimentalnojj biologii i mediciny. 2004. T. 138. № 10. S. 393-396.