G.A. Bilalova -bPh.D. (Biol), Associate Professor, Department of Anatomy, Physiology and Human Health of Kazan (Volga Region) Federal University. E-mail: g.bilalova@mai.ru L.M. Kazanchikova - Kazan (Volga Region) Federal University. E-mail: klilijam@mail.ru F.G. Sitdikov - Dr.Sc. (Biol.), Professor, Department of Anatomy, Physiology and Human Health, Kazan (Volga Region) Federal University. E-mail: fgsitdikov@mail.ru N.B. Dikopolskaya - Ph.D. (Biol), Associate Professor, Department of Anatomy, Physiology and Human Health, Kazan (Volga Region) Federal University. E-mail: bettydn@mail.ru M.V. Shayhelislamova - Dr.Sc. (Biol.), Professor, Department of Anatomy, Physiology and Human Health, Kazan (Volga Region) Federal University. E-mail: bettydn@mail.ru

Catecholamines are capable to influence metabolic, immune processes, operability of a cardiac and skeletal muscle quickly. Regulatory influence of monoamine of dopamine (DA) on the contractility of the myocardium in ontogenesis is investigated insufficiently. It is known that in up symptomatic and early symptomatic stages of Parkinson\'s disease of the one can observe changes in the concentration of dopamine in the heart. Perhaps, changes in the contractility of the myocardium under the action of dopamine may serve as potential markers of Parkinson\'s disease. The aim of this study was to examine the influence of different dopamine concentrations in the contractility of the myocardium of the right atrium and right ventricle on the background of the siege d-receptors by droperidol (Sigma). The Experiments were made on white laboratory rats 21-and 100-day age, with observance of bioethical rules. Isometric reduction of strips of a myocardium of auricles and ventricles was registered on the Power Lab installation (ADInstrumets) with the sensor of force of \"MLT 050/D\" (\"ADInstruments\"). The reaction force of contraction of the myocardium on increasing the concentration of dopamine (Sigma) was determined in the range 10-9...10-5M. The reaction force of contraction in response to dopamine was calculated in percent from the original, which was taken as 100%. Reliability of distinctions was counted by Student t- test. It is revealed, at switching off of d-receptors dopamine in concentration 10-5М causes positive inotropic effect at 21-day rats. All subsequent concentration of dopamine (10-9М, 10-8М, 10-7М) reduced force of contraction of the myocardium of the auricles and ventricles. At 100-day animals against blockade of d-receptors the positive inotropic effect of a myocardium of auricles and ventricles remains in all studied concentration (10-9...10-5М). Therefore, at this stage of ontogenesis, at formation of sympathetic regulation of action of the heart the dose-dependent effect of dopamine is realized through different types of receptors.

 

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