N.N. Aliyeva - Ph.D. (Biol.), Associate Professor, Institute of Physiology n.a. A.I. Garayev, Azerbaijan National Academy of Science (Baku). E-mail: nazaket-alieva@mail.ru

Main mechanisms of interactions and regulations between the immune, endocrine and nervous systems are reviewed [1]. The neurotransmitter system of the brain involved in regulating the formation of the immune system [3]. For determine of changes in the content of free amino acids studied in the brain it was necessary to study activities of enzymes involved in their synthesis and splitting. Therefore, to identify of the changes in the content of GABA in the mitochondria of the brain, it was necessary to study activities of enzymes involved in the synthesis (GAD) and the splitting of the GABA (GABA-T) [2]. It was established the activity of the enzyme GAD increases in the mitochondria of the brain structures in 10-day-old rats after influence thymalinum (5 mg/kg, 5 days), but the activity of the enzyme GABA-T decreases compared to the control group of animals. Results shows, that after influence of thymalinum in the mitochondria of the brain the ratio GAD/GABA-T increases as compared with the control. Thus, after the action of thymalinum the content of GABA increased in the mitochondria of the brain structures in 10-day old rats from one side by increasing its synthesis of Glu in result of increased the activity of the enzyme of the GAD, on the other side, due to its use of small (GABA shunt) which is caused by the suppression of the activity of the enzyme GABA-T.

 

1. Beloglazov V.A., Koshukova G.N., Alekseeva A.A. Vzaimodejjstvie osnovnykh reguljatornykh sistem organizma // Krymskijj terapevticheskijj zhurnal. 2007. T. 2. № 2. S. 24-30.
2. Tjurenkov I.N., Samotrueva M.A., Serezhnikova T.K. GAMK-ergicheskaja sistema i preparaty GAMK v reguljacii immunogeneza // EHksperimentalnaja i klinicheskaja farmakologija. 2011. T. 74. №11. S. 36-42.
3. Lelevich V.V., Vinickaja A.G., Lelevich S.V. Sovremennye predstavlenija ob obmene γ-aminomasljanojj kisloty v golovnom mozge // Nejjrokhimija. 2009. T. 26. № 4. S. 275-281.