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Journal Biomedical Radioelectronics №6 for 2014 г.
Article in number:
Mechanisms of hypoalgesic effect of millimeter waves
Keywords: peripheral nervous system pain models cutaneous receptors nerves membranes
Authors:
S.I. Alekseev - Dr.Sc. (Biol.), Institute of Cell Biophysics of Russian Academy of Sciences, Pushchino, Moscow Region. E-mail: stan.alexeev@gmail.com
Ziskin Marvin C. - MD, Center for Biomedical Physics, Temple University Medical School, Philadelphia, USA. E-mail: ziskin@temple.edu
E.E. Fesenko - Dr.Sc. (Biol.), Professor, Corresponding member of RAS, Institute of Cell Biophysics of Russian Academy of Sciences, Pushchino, Moscow Region. E-mail: fessenko@mail.icb.psn.ru
Abstract:
In the review the results of study of the millimeter wave (MMW) effects on organism covering different levels of signal transfer from cell membranes to CNS resulting in hypoalgesic effect are described. Literature data obtained on humans in double-blinded experiments indicate that MMW exposure caused a significant reduction of pain sensitivity. In animal (mice) experiments the maximal hypoalgesic effect was observed at exposure of the most densely innervated sites of a body - nose and pads. Deinnervation of exposed limb resulted in disappearance of hypoalgesic effect. This result clearly demonstrated that the interaction of MMW with cutaneous nerve endings was the essential step in the initialization of biological effects of MMW exposure. This conclusion was confirmed with the direct investigations of MMW effect on electrical activity of murine sciatic nerve, which was subjected to complex changes in response to exposure of the receptive field of the nerve. The ability of MMW to stimulate the cutaneous nerve endings in animals was also demonstrated using the method of immunohystochemical staining of c-fos gene proteins. There is a solid evidence of involving the complex human neurohumoral system in MMW reception. In the review the numerous data are given related to the MMW effects on the electrical properties of nerves, cutaneous receptors, neurons, cell and artificial membranes. The possible primary mechanisms underlying MMW effects on the biological structures are examined. In conclusion, it is expressed that the experimental and theoretical approaches described previously and developing at the present time will allow finding out the mechanisms of MMW effects on the peripheral nervous system in detail.
Pages: 55-65
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