V.F. Kirichuk - Dr.Sc. (Med.), Professor, Head of Department of Normal Physiology named after I.A. Chuevsky, Saratov State Medical University named after V.I. Razumovsky. E-mail: aa-tsymbal@yandex.ru
A.A. Tsymbal - Ph.D. (Med.), Associate Professor, Department of Normal Physiology named after I.A. Chuevsky, Saratov State Medical University named after V.I. Razumovsky

The submitted article contains extensive data on numerous experimental studies on the interaction of terahertz waves at frequencies of molecular spectrum of emission and absorption of nitric oxide with biological objects. As biosamples used as individual cells (platelets) as well as experimental animals. The experimental studies of the interaction of electromagnetic radiation in the terahertz frequency range of nitric oxide with biological objects revealed a number of positive effects of this wave frequencies that could be used in clinical practice for the normalization of systemic hemodynamics and microcirculation. Great scientific interest is the study of mechanisms for the implementation of these effects. Found that the changes caused by the terahertz waves are detected at the cellular, tissue, system and organism levels. The article presents data on changes in the physiological mechanisms of regulation at all levels: an autocrine, paracrine, endocrine and nervous .This article was first conducted a comprehensive review of the accumulated experimental material. It is shown that the effect of terahertz waves of these frequencies is realized mainly due to changes in activity of nitrergic system. It is proved that terahertz waves at frequencies of molecular spectrum of nitrogen oxide are capable of stimulating the production of nitric oxide in organs and tissues in a reduced concentration. There are roughly three levels of the effects of increasing the activity of NO under the influence TGCH - effects: a direct effect on the cells - autocrine effect, the impact on the fabric as a whole - paracrine regulation of the activity of neighboring cells and the central effects - NO- dependent changes in neural and humoral regulation .The possible mechanisms of the effect of waves antiagregatsionnogo the frequency. The possibility of the regulation of vascular tone and systemic hemodynamics by radiation of these frequencies. The data on changes in lipid peroxidation and the status of enzymatic and non-enzymatic antioxidant systems of the body under the influence of terahertz waves at frequencies of nitric oxide in conditions of stress. Also shown are the stress change activity implementing systems and concentration of these systems the most important mediators of catecholamines and glucocorticoids. These data allow us to describe the mechanism of the main effects of electromagnetic terahertz waves. Studies have shown the possibility of using terahertz waves at frequencies of nitric oxide as a natural method of noninvasive physiological regulation of a number of important body functions.