T. V. Vinogradova - Ph.D. (Biol.), Senior Research Scientist, Federal State Budgetary Institution «Research Institute of Experimental Medicine» under the North-West Branch of Russian Academy of Medical Sciences, Saint-Petersburg
N. N. Klyueva - Ph.D. (Biol.), Research Scientist, Federal State Budgetary Institution «Research Institute of Experimental Medicine» under the North-West Branch of Russian Academy of Medical Sciences, Saint-Petersburg. E-mail: nnklyueva@gmail.com
A. G. Pshenichnaya - Junior Research Scientist, Federal State Budgetary Institution «Research Institute of Experimental Medicine» under the North-West Branch of Russian Academy of Medical Sciences, Saint-Petersburg
A. G. Kusov - Ph.D. (Med.), Research Scientist, Federal State Budgetary Institution «Research Institute of Experimental Medicine» under the North-West Branch of Russian Academy of Medical Sciences, Saint-Petersburg
G. В. Beznin - Junior Research Scientist, Federal State Budgetary Institution «Research Institute of Experimental Medicine» under the North-West Branch of Russian Academy of Medical Sciences, Saint-Petersburg N. G. Nikulcheva - Dr. Sc. (Med.), Leading Research Scientist, Federal State Budgetary Institution «Research Institute of Experimental Medicine» under the North-West Branch of Russian Academy of Medical Sciences, Saint-Petersburg S. G. Tsikunov - Dr. Sc. (Med.), Professor, Head of Laboratory, Federal State Budgetary Institution «Research Institute of Experimental Medicine» under the North-West Branch of Russian Academy of Medical Sciences, Saint-Petersburg

We have developed a model (the experience of rats kept in a terrarium in python stress - a threat to life), which is more consistent with the etiology of PTSD. Zoosocial conflict - method of cohabitation intact rats with rat-s izolyantami. Relevance of such work is not in doubt. According to WHO, more than 30 % of women and 20 % of men suffer from PTSD after experiencing acute stress - Over 25 % of women and 10% of men at least once in a lifetime transferred depressive episode. It is known that female rats compared with males more resistant to mild stressors and demonstrate a greater increase in the level of ACTH in response to acute exposure. In acute stress male rats are trained better than females. Male rats are more sensitive to the effects of chronic stress. Thus, comparative studies of acute and chronic psychogenic stress are necessary for understanding the biochemical and behavioral mechanisms that are the consequences of such actions. When a single traumatic experience, a threat to life found, a sharp decline in high density lipoprotein cholesterol (HDL-C) and triglycerides (TG) in the serum of male rats, which occurs immediately after a traumatic impact. These changes are stored in 2 weeks, and a month after the stress of HDL-C remains at significantly reduced levels, whereas TG sharply. In female rats, there is a somewhat different picture of changes in lipid profile of blood serum, but which also leads to atherogenic changes in the lipid metabolism [1]. In females, immediately after the stress level of HDL-C significantly increases and decreases only a week after a single stress. After a month in the females and the males and stored atherogenic changes not only in serum, but also in the liver. Liver is even visually fatty [2, 3]. Experiments on chronic stress (zoosocial conflict) conducted only on male rats. Under such stress, especially noteworthy that there is no reduction or HDL-C or TG. [4]There is an increase in total cholesterol and lowering triglycerides in the blood serum. The liver is a slight but significant increase in cholesterol and triglycerides are not changed. When comparing the behavior of rats under such stress revealed that psychogenic stress - a threat to life, except depressive - like state causes pathological aggression, which is not observed in chronic stress.