350 rub
Journal Biomedical Radioelectronics №12 for 2014 г.
Article in number:
Equipment with quasi-optical path for biomedical research in the EHF and the terahertz frequency bands
Keywords: EHF-therapy biological effect spectral lines
Authors:
A.P. Кrenitchkiy - Ph.D. (Phys.-Math.), General Director, JSC «CIME» (Saratov). E-mail: alex@cime.ru
Yu.A. Kurchatov - Ph.D. (Eng.), Head of the Laboratory, JSC «CIME» (Saratov). E-mail: kurchatov500@yandex.ru
A.V. Terekhin - Head of the Department, JSC «CIME» (Saratov). E-mail: 07anatoli07@rambler.ru
Abstract:
Created measuring complex consisting of a series of nodes with quasi-optical path and equipment, designed to examine the effect of low-intensity electromagnetic radiation on living systems. Measuring complex allows for a range of frequencies (120160) GHz (160260) and GHz (260535) GHz: a) irradiation of biological media at selected frequencies; b) measurement of the spectral characteristics and frequency of the irradiating field; d) measuring the VSWR in the quasi-optical path; d) measuring the attenuation in quasi-optical path. Generators and receivers in all installations  interchangeable depending on the frequency band. Applied in a complex quasi-optical path, collected from the functional units of hollow dielectric beam guide (lumen diameter of 20 mm), operating range (0.1...0,6) THz. Measuring system for the irradiation of biological media has the ability to customize the radiation generators at selected frequencies, measurement and power changes, changes in the polarization of the radiation from linear to circular left and right circular, radiation modulation (amplitude, frequency and noise with a given law of the amplitude distribution in the low-frequency region), time irradiation. Measuring complex allows irradiation of in vitro and in vivo. Under in vitro conditions investigated medium in the flask is placed inside a path that allows to isolate it from external natural and artificial turf. In the in vivo conditions in the medium under study the effects of radiation from the open end of the beam guide) or by using a part of the complex lens antenna having a small loss in the frequency range and polarization-preserving fed to her radiation. The results of studies of the effect on the biological effects of frequencies and power density, types of polarization and modulation of the radiation on the selected frequencies for the study of near: 0.129 THz (second band O2), 0.15 THz (first band NO), 0,24 THz (2 Star band NO) and 0.4 THz (3rd lane NO). It is found that the optimum use of generators with linear polarization and frequency-modulated low frequency modulation, frequency deviation which exceeds the range of frequencies of the spectral lines belonging to the selected band to provide the highest intensity of the biological effects, to simplify the design and operation of the measuring complex. Includes information on the use of measuring complex for the study of therapeutic effects in human and veterinary medicine.
Pages: 44-55
References

  1. Devyatkov N.D., Golant M.B., Betskiy O.V. Millimetrovye volny i ikh rol' v protsessakh zhiznedeyatel'nosti. M: Radio i svyaz'. 1991. 168 s.
  2. Belyaev I.Ya., Shcheglov V.S., Alipov Ye.D., Uchskov V.L. Nonthermal effects of extremely high-frequency micro­waves on chromatin conformation in gells in vitro-dependence on physical, physiological and genetic factors // Proceed. IEEE Transactions on microwave theory and techniquis. 2000. V. 48. № 1. P. 2172-2179.
  3. Betskiy O.V., Devyatkov N.D., Lebedeva N.N. Lechenie elektromagnitnymi volnami. Ch. 1-3 // Biomeditsinskaya radioelektronika. 2000. № 7. S. 3-9; № 10. S. 8-32; № 12. S. 11-30.
  4. Betskiy O.V., Lebedeva N.N. Nizko intensivnye millimetrovye volny v biologii i v meditsine. Osnovnye dostizheniya // Millimetrovye volny v biologii i meditsine. 2011. Vyp. 4 (64). S. 40-74.
  5. Vanin A.F. Nobelevskaya premiya 1998 goda po fiziologii i meditsine // Uspekhi fizicheskikh nauk. 1999. № 1. S. 58(62.
  6. Kirichuk V.F., Krenitskiy A.P., Mayborodin A.V. i dr. Oksid azota i elektromagnitnoe izluchenie KVCh // Biomeditsinskie tekhnologii i radioelektronika. 2002. № 10(11. S. 95(108.
  7. Rothman L.S., Barbe A., Chris Benner D., et al. The HITRAN molecular spectroscopic database: edition of 2000 including updates through 2001 // Journal of Quantitative Spectroscopy & Radiative Transfer. 2003. № 82. P. 5-44.
  8. Betskiy O.V., Krenitskiy A.P., Mayborodin A.V. i dr. Molekulyarnye HITRAN-spektry gazov-metabolitov v teragertsovom i IK diapazonakh chastot i ikh primenenie v biomeditsinskikh tekhnologiyakh // Millimetrovye volny v biologii i meditsine. 2007. № 1(45). S. 60-64.
  9. Mayborodin A.V., Krenitskiy A.P., Tupikin V.D. i dr. Panoramno-spektrometricheskiy kompleks dlya issledovaniy tonkikh struktur molekulyarnykh spektrov fizicheskikh i biologicheskikh sred // Biomeditsinskaya radioelektronika. 2001. № 8. S. 35-47.
  10. Basharinov A.Ye., Tuchkov L.T., Polyakov V.M. Izmerenie radioteplovykh i plazmennykh izlucheniy v SVCh-dia­pazone. M.: Sov. radio. 1968.
  11. Krenitskiy A.P., Kurchatov Yu.A., Mayborodin A.V. i dr. Funktsional'nye ustroystva SVCh-, KVCh- i submillimetrovogo diapazonov. M.: Radiotekhnika. 2003. № 2. S. 79-93.
  12. Otchet po NIR «Issledovanie vozmozhnosti sozdaniya radioizmeritel'noy apparatury submillimetrovogo diapazona s ispol'zovaniem opticheskikh printsipov» // Shifr «Ozero». Khar'kovskiy institut radiotekhniki i elektroniki AN USSR. 1961.
  13. Otchet po OKR «Razrabotka komplekta radioizmeritel'nykh ustroystv millimetrovogo i submillimetrovogo diapazona» // Shifr «Rebus-1». TsNIIIA. Saratov. 1988.
  14. Krenitskiy A.P., Kurchatov Yu.A., Koplevatskiy N.A. Apparat KVCh-terapii «Orbita» // Biomeditsinskaya radioelektronika. 2014. № 2. S. 58-64. 
  15. Krenitskiy A.P., Alaverdyan S.A., Meshchanov V.P. Kvaziopticheskie i volnovodnye komponenty na osnove plenochnykh struktur dlya diapazonov SVCh, KVCh i TGCh // Antenny. 2012. № 3 (178). S. 15-17.
  16. Alaverdyan S.A., Bokov S.I., Bulgakov V.O., Zaytsev N.A., Isaev V.M., Kabanov I.N., Katushkin Yu.Yu., Komarov V.V., Krenitskiy A.P., Meshchanov V.P., Savushkin S.A., Syromyatnikov A.V., Yakunin A.S. Teragertsovyy diapazon chastot: elektronnaya komponentnaya baza, voprosy metrologicheskogo obespecheniya // Obzory po elektronnoy tekhnike. Ser. 1. Elektronika SVCh. M.: TsNII «Elektronika». 2012. 74 s.
  17. Alaverdyan S.A., Bokov S.I., Zaytsev N.A., Isaev V.M., Kabanov I.N., Krenitskiy A.P., Meshchanov V.P. Setochnye struktury polyarizatsii elektromagnitnykh voln v teragertsevom diapazone chastot // Elektromagnitnye volny i elektronnye sistemy. 2012. T. 17. № 12. S. 47-50.
  18. Alaverdyan S.A., Bokov S.I., Savushkin S.A., Isaev V.M., Kabanov I.N., Komarov V.V., Krenitskiy A.P., Meshchanov V.P., Yakunin A.S. Peredatochnye kharakteristiki setochnykh polyarizatorov teragertsevogo diapazona // Dinamika slozhnykh sistem. 2012. T. 6. № 4. S. 90-95.
  19. Alaverdyan S.A., Bokov S.I., Bolov V.R., Zaytsev N.A., Isaev V.M., Kabanov I.N., Komarov V.V., Krenitskiy A.P., Meshchanov V.P., Savushkin S.A., Chirkin V.V., Yakunin A.S. Ustroystva polyarizatsii radiovoln v teragertsevom diapazone chastot. Novye printsipy postroeniya. / Pod red. A.S. Yakunina. M.: Radiotekhnika. 2012. 256 s.
  20. Spravochnik po spetsial'nym funktsiyam / Pod red. M. Abramovitsa i I. Stigan. M.: Nauka. 1979.
  21. Born M., Vol'f E. Osnovy optiki. M: Nauka. 1973.
  22. Chernushenko A.M., Mayborodin A.V. Izmerenie parametrov elektronnykh priborov detsimetrovogo i santimetrovogo diapazonov voln. M: Radio i svyaz'. 1986. 336 s.
  23. GOST 8.249 - 77.
  24. Kryuchkov V.S., Polunin V.A., Alipov Y.D., and Belyaev I.Y. Physical model of anomalous viscosity time dependence in solutions of highpolymer DNA-protein complexes // Biofizika. 1995. V. 40. P. 1202-1207.
  25. Raboty uchenykh g. Saratova v oblasti millimetrovoy elektromagnitobiologii i meditsiny // Biomeditsinskie tekhnologii i radioelektronika. 2004. № 11. S. 4-45.
  26. Raboty uchenykh g. Saratova v oblasti millimetrovoy elektromagnitobiologii i meditsiny» // Biomeditsinskie tekhnologii i radioelektronika. 2004. № 11. S. 62-64.
  27. Shub G.M., Pronina Ye.A., Krenitskiy A.P., Mayborodin A.V., Tupikin V.D., Rytik A.P., Betskiy O.V., Gulyaev Yu.V. Vozdeystvie elektromagnitnogo izlucheniya spektra pogloshcheniya molekulyarnogo kisloroda na rost prokarioticheskikh kletok // Sbornik dokl. 13-go Ross. simpoziuma s mezhd. uchastiem «Millimetrovye volny v meditsine i biologii» (1-3 dekabrya 2003 g.). M. 2003. S. 102-105.      
  28. Kirichuk V.F., Andronov Ye.V., Antipova O.N., Yefimova N.V., Krenitskiy A.P., Mayborodin A.V., Betskiy O.V. Vliyanie teragertsovogo izlucheniya na chastote oksida azota 240 GGts na agregatsionnuyu aktivnost' trombotsitov belykh krys v sostoyanii oksidativnogo stressa // Millimetrovye volny v biologii i meditsine. 2009. № 1-2 (53-54). S. 55-62.
  29. Kirichuk V.F., Andronov Ye.V., Tupikin V.D., Krenitskiy A.P., Mayborodin A.V., Betskiy O.V. Teragertsovoe izluchenie na chastote 400 GGts oksida azota i agregatsionnaya aktivnost' trombotsitov bol'nykh nestabil'noy stenokardiey // Biomeditsinskie tekhnologii i radioelektronika. 2006. № 5-6. S. 4-8.
  30. Primenenie KVCh terapii v veterinarnoy meditsine. Spetsial'nyy vypusk k 100-letiyu Saratovskogo gosudarstvennogo agrarnogo universiteta im. N.I. Vavilova // Millimetrovye volny v meditsine i biologii. 2003. Vyp. 3(31).
  31. Avdeenko V.S., Kalyuzhnyy I.I., Zolotar' Yu.O., Krenitskiy A.P., Mayborodin A.V., Tupikin V.D. Vliyanie EMI KVCh MSPI O2 na funktsional'noe sostoyanie krovi zhivotnykh in vitro // Millimetrovye volny v meditsine i biologii. 2003. № 3. S. 11-20.