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Journal Biomedical Radioelectronics №9 for 2011 г.
Article in number:
Magnetic Iron Oxide Nanoparticles as Magnetic Resonance Contrast Media and Fluorescent Agents
Keywords: uperparamagnetic nanoparticles magnetic resonance tomography magnetic-resonance contrast media
Authors:
A.G. Akodjanov, A.V. Babich, I.V. Bykov, V.Yu. Naumenko, A.I. Segeev, N.L. Shimanovskii, G.Yu.Yurkov
Abstract:
Superparamagnetic iron oxide nanoparticles with appropriate surface chemistry have been widely used experimentally for numerous in vivo applications such as magnetic resonance imaging contrast enhancement, tissue repair, immunoassay, detoxification of biological fluids, hyperthermia, drug delivery and in cell separation, etc. All these biomedical and bioengineering applications require that these nanoparticles have high magnetization values and size 10 nm with overall narrow particle size distribution, so that the particles have uniform physical and chemical properties. In addition, these applications need special surface coating of the magnetic particles, which has to be not only non-toxic and biocompatible. Application of iron oxide nanoparticles with superparamagnetic and fluorescent properties allows to combine methods of magnetic resonance and fluorescent visualization for diagnostic tumors. Estimation values of re-laxation times Т1 and Т2 of colloid solituions in different concentration of particles are 120?20 ms and 14?1 ms respectively. It has been observed the improvement of small vessels visualization in brain of rats after intravenous injec-tion of 0,1 ml of solution contained 5,1 mg of ferrous. After injection of iron nanoparticles the tumor in rats became better contrasting and delineated by use T1, weighted and Т2 weighted sequences. Moreover iron nanoparticles demarcate possibility to give contrast en-hancement of blood vessels. It has been found the fluorescent properties of these iron nanoparticels in the field of wave 554 nm after ir-radiation of light with UV light by use lumiscent microscope EC LUMAM-RPО11. This article discusses the synthetic chemistry of superparamagnetic iron oxide nanoparticles, as well as their use for biomedical applications.
Pages: 28-36
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