V.F. Kirichuk, O.N. Antipova, J.A. Tomina, I.V. Smyshlyaeva, E.V. Andronov, A.A. Tsymbal, A.P. Krenitsky

Conducted the study of whole blood 75 white male rats and 150 female rats weighing 180-220 g. As the model simulating a violation of microcirculation, we used the immobilization stress: Rigid fixation of the rats on their backs for 3 hours. Once daily preventive exposure of the animals, prior to immobilization stress, was carried out small-sized generator «UHF-NO-orbit» at frequencies MSIP nitric oxide 150,176-150,664 GHz. The study was conducted on 15 groups of white male rats and female rats, each of which had 15 individuals. Rheological properties of whole blood was studied in samples of the volume of 0.85 ml with a rotary viscosimeter AKR-2. Determined the viscosity of whole blood at shear rates 300, 200, 150, 100, 50, 20, 1, 10 s-1, 5 s-1. Based on these data the indices of aggregation (IAE), and erythrocyte deformability (EDI). The results of these studies show that 3-hour immobilization leads to severe stress reactions, manifested as a change in animal behavior (aggression, response to weak stimuli) as well as indicators of blood rheology - an increase of whole blood viscosity at all shear rates, Increased erythrocyte aggregation and deformability in comparison with those of control group animals. It is shown that a 5-minute exposure preventive treatment has no effect on dolzhenstvuyuschego prevention of stress-dependent changes in blood rheological properties and functional activity of erythrocyte. However, male rats observed a positive trend, in contrast to female rats, the study of blood rheology on shear rates 300, 200, 150, 100, 50 and 20 s-1. 15 and 30-minute regimes preventive effects of electromagnetic terahertz waves at frequencies MSIP nitric oxide 150,176-150,664 GHz effective and completely prevent stress-dependent viscosity of blood disorders and functional activity of erythrocytes in male rats and female rats in the phases Dioestrus and Oestrus.