V.F. Kirichuk, A.N. Ivanov, T.S. Kiriyazi, E.V. Andronov, N.E. Babichenko, I.V. Smyshlyaeva, M.A. Sakhan

A study of the mechanism of corrective actions terahertz waves at frequencies of molecular spectrum of emission and absorption of nitric oxide 150,176-150,664 GHz disorders microcirculatory perfusion of skin and state of the endothelium of white male rats during acute immobilization stress. To study the mechanism of the positive effect of terahertz waves at frequencies of molecular spectrum of emission and absorption of nitric oxide 150,176-150,664 GHz on the microcirculation of male rats exposed to acute immobilization stress, we studied rates of skin microcirculatory perfusion during irradiation for 30 minutes against the introduction of a nonspecific inhibitor of NO synthase L-NAME. The absence of a normalizing effect on parameters of perfusion with 30-minute irradiation of terahertz waves at frequencies of molecular spectrum of emission and absorption of nitric oxide 150,176-150,664 GHz in the microcirculatory bed of animal skin, in a state of acute immobilization stress on the action of an inhibitor of endothelial NO-synthase L-NAME. The absence of influence of terahertz waves at a reduced amplitude of oscillations of endothelial animals in a state of acute stress, the introduction of L-NAME indicates that the blockade of endothelial NO-synthase, THZ-irradiation is unable to restore basal nitric oxide production by endothelial cells. Lack of dynamics of termoproby animals in a state of acute stress on the background of the introduction of L-NAME under the influence of THZ-irradiation leads to the conclusion that the blockade NOS terahertz waves do not encourage induced production of endothelial NO. The data obtained indicates that the role of endogenous nitric oxide and endothelial NO-synthase in the mechanisms of potentiation of the positive corrective effect of irradiation on the frequencies of nitric oxide 150,176-150,664 GHz impaired microcirculatory perfusion indices skin and endothelial function in white rats during acute immobilization stress.