350 rub
Journal Biomedical Radioelectronics №12 for 2011 г.
Article in number:
Possible Applications of Nanoscale Iron Oxide Particles for Treating Tumors by Hyperthermia
Keywords: hyperthermia superparamagnetic nanoparticles magnetic resonance tomography magnetic-resonance contrast media
Authors:
V.U. Naumenko, A.G. Akopdzhanov, A.V. Babich, I.V. Bykov, N.L. Shimanovskiy
Abstract:
A brief review of the application of superparamagnetic iron oxide nanoparticles application for treatment of tumors by hyperthermia is presented. Practical use of solutions of nanoparticles is associated with their stabilization, which is achieved by the application of organic and inorganic coating on the surface of the nanoparticles, as well as the use of surfactants. Ways to improve the stability of colloidal solutions, containing superparamagnetic nanoparticles, and magnetic contrast agents, based on such solutions are considered. А number of drugs based on superparamagnetic iron oxide nanoparticles, as well as the ways of targeted delivery of drugs in local body areas, are described. The article also specifies problems, that have to be solved to apply hyperthermia in practice, the main one being - is the local temperature rise of tissue above the normal temperature 37,5 ° C, since the process of heating the tumor in the body depends strongly on the homogeneity of the tissue, on the distribution of nanoparticles in it and blood perfusion of the tumor. It is necessary to consider the cooling effect of blood flow during hyperthermia because the level of tissue heating depends on the blood flow rate. It should be stressed that hyperthermia, probably, increases immune response of organism, taking into account that heat shock proteins mask tumor antigens, but the removal of this effect by hyperthermia could be the mechanism that was responsible for the increase of antitumor immunity. The prospect of application of colloidal solutions based on magnetic nanoparticles of iron oxide is shown by possibility of creation drugs that can be used as contrast agents for magnetic resonance imaging of blood vessels and organs. Particular attention is paid to the development of techniques to remove tumors and treatment of cancer patients using an electromagnetic thermotherapy.
Pages: 19-27
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