V.F. Kirichuk, A.N. Ivanov, T.S. Kiriyazi, O.N. Antipovа, N.E. Babichenko, A.P. Krenitsky

The effect of preventive treatment with terahertz waves iradiation at the frequencies of molecular spectrum of emission and absorption of nitric oxide 150.176...150.664 GHz on peripheral perfusion disoders in white rats during acute immobilization stress was studied. Determination of peripheral perfusion and the mechanisms of its regulation was measured by laser Doppler flowmetry. The study was conducted on three groups of animals: control, comparison and experimental. It was found that male rats in a state of acute immobilization stress has disturbed peripheral perfusion, which manifests itself reduced the average perfusion, inhibition of active mechanisms of regulation mikrobloodflow, a decrease in basal vasodilating activity of endothelium of microvessels (a decrease of basal release of nitric oxide), increased peripheral resistance. The results of these studies suggest that preventive treatment with electromagnetic waves iradiation at terahertz frequencies of nitric oxide molecular spectrum of emission and absorption 150.176...150.664 GHz hinder the development of typical acute stress reaction violations peripheral perfusion in male rats. This manifests itself preserving the normal level of the average perfusion, the activity of regulatory mechanisms mikrokrovotoka, basal vasodilating activity of endothelium of microvessels peripheral resistance. The greatest effect of terahertz waves at frequencies of molecular spectrum of emission and absorption of nitric oxide 150.176...150, 664 GHz is aimed at changing the active modulation mechanisms mikrobloodflow (vasodilating activity of vascular endothelium and peripheral resistance), which probably is associated with preservation of normal levels of basal isolation oxide nitrogen. Thus, irradiation of electromagnetic waves at terahertz frequencies of molecular spectrum of emission and absorption of nitric oxide 150.176...150.664 GHz is effective in preventing microcirculatory disturbances, which can be used in clinical practice.