A.A. Savina - Ph.D.(Chem.), Leading Scientific Researcher, All-Russian Scientific Research Institute of Medical and Aromatic Plants RAS (Moscow) V.I. Sheichenko - Ph.D.(Phys.-Math.), Leading Scientific Researcher, All-Russian Scientific Research Institute of Medical and Aromatic Plants RAS (Moscow) T.A. Sokol´skaya - Dr.Sc.(Pharm.), Professor, First Deputy Director, All-Russian Scientific Research Institute of Medical and Aromatic Plants RAS (Moscow) M.M. Il΄yin - Ph.D.(Chem.), Research, A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences T.A. Fateeva- Head of the Laboratory, All-Russian Scientific Research Institute of Medical and Aromatic Plants RAS (Moscow) O.F. Lasskaya - Researcher, All-Russian Scientific Research Institute of Medical and Aromatic Plants RAS (Moscow) M.K. Bulusheva - Post- graduate Student, All-Russian Scientific Research Institute of Medical and Aromatic Plants RAS (Moscow) I.A. Kir΄yanova - Senior Researcher, All-Russian Scientific Research Institute of Medical and Aromatic Plants RAS (Moscow) A.I. Gromakova - Dr.Sc.(Pharm.), Chief Scientific Researcher, All-Russian Scientific Research Institute of Medical and Aromatic Plants RAS (Moscow)

There have been carried out the investigation chemical composition of Salvia officinalis roots in order to create a new technology of the antibacterial drug. The roots, collected in Krasnodar region near the village Vasyurinskaya, was treated with chloroform. The extract was evaporated, the residue was dissolved in acetone. The solution after filtration was evaporated to the dry residue, which was chromatographed on SG column, uring CHCL3 as the eluent. There were isolated royleanone, horminone, 7-acetoxyhorminone, 7-oxohormi-none. The presence of taxoquinone and 6,7-dehydroroyleanone was confirmed by the 1H NMR spectra in the crude fractions horminone and royleanone consequently. 7-Oxoroy-leanone, taxoquinone, 6,7-dehydroroyleanone were found in the Salvia officinalis roots for the first time. The native nature of the total royleanones was confirmed by the HPLC. The royleanones were characterized in respect of antibacterial activity. The most active compound was found to be hominone.

 

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