350 rub
Journal №2 for 2015 г.
Article in number:
Micrornas - new promising tumor biological markers and targets for chemotherapy. Part 1 The history of microRNA discovery, their biogenesis and the use. The role of microRNA as a biomarker
Keywords: microRNA history of discovery carcinogenesis diagnostics antitumor therapy
Authors:
A.N. Shirshova - Researcher, Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine Siberian Branch of the Russian Academy of Sciences (ICBFM SB RAS), Novosibirsk
M.A. Smetanina - Ph.D.(Biol.), Researcher, Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine Siberian Branch of the Russian Academy of Sciences (ICBFM SB RAS), Novosibirsk
V.N. Aushev - Ph.D.(Med.), Senior Researcher, Laboratory of Oncogenes Regulation, Carcinogenesis Institute, N.N.Blokhin Russian Cancer Research Center, Moscow
M.L. Filipenko - Ph.D.(Biol.), Head of the laboratory of pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine Siberian branch of the Russian Academy of Sciences, Novosibirsk
N.E. Kushlinskii - Dr.Sc. (Med.), Professor, Head of the Clinical Biochemistry Laboratory, N.N. Blokhin Russian Cancer Research Center, Moscow
Abstract:
The discovery of negative regulation of gene expression by small non-coding RNAs - microRNAs - is one of the prominent events in the biology of the last fifteen years. MicroRNAs are the most important and universal regulatory molecules playing the key roles in the majority of events in eukaryotic cell. Disturbances of the mechanisms of microRNA-dependent regulation were revealed in different severe human pathologies, and primarily in oncologic diseases. Main phases of the history of micro RNA discovery, their biogenesis and role in normal conditions, and in malignant tumors initiation, progression, diagnostics and therapy are presented in this review.
Pages: 33-43
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