350 rub
Journal №1 for 2015 г.
Article in number:
Structural-functional state of the cytochromic part of liver mitochondria respiratory chain under the conditions of alimentary deprivation of protein
Keywords: alimentary deprivation of protein mitochondria cytochromes b c1 с aа3 cytochrome oxidase &#948 -aminolevulinate synthase heme oxygenase
Authors:
O.N. Voloshchuk - Ph.D. (Biol.), Associate Professor, Yuriy Fedkovych Chernivtsi National University (Chernivtsi, Ukraine). E-mail: oxbm@mail.ru
G.P. Kopylchuk - Dr.Sc. (Biol.), Professor, Yuriy Fedkovych Chernivtsi National University (Chernivtsi, Ukraine). E-mail: kopilchuk@gmail.com
Abstract:
Activity of the key enzyme of the cytochromic part of respiratory chain - cytochrome oxidase, quantitative redistribution of the mitochondrial cytochromes b, c1, с and aа3, activity of the key enzymes of cytochromes - heme metabolism ? δ-aminolevulinate synthase and heme oxygenase under the conditions of alimentary deprivation of protein were studied in the research. The research was carried out on white non-linear rats, divided according to quantity of protein in the ration into groups: 1 - rats maintained on low-protein diet, 2 - rats maintained on full semi-synthetic ration. It was estimated, that under the conditions of alimentary deprivation of protein decrease of the quantitative content of mitochondrial cytochromes b, c1, с and aа3 in the liver mitochondrial fraction, inhibition of the activity of key enzyme of the cytochromic part of respiratory chain - cytochrome oxidase against the background increase of the heme oxygenase activity and maintenance on the control level δ-aminolevulinate synthase activity is observed. Conclusion was made, that estimated changes of the structural-functional organization of cytochromic part of respiratory chain may be considered as one of the possible mechanisms of energy biotransformation system disturbances under the conditions of alimentary deprivation of protein.
Pages: 43-47
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