V.E. Ferubko - Ph.D. (Med.), Head of the Laboratory of Pharmacology, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants, Moscow. E-mail: iriss86@mail.ru
I.A. Lupanova - Ph.D. (Biol.), Research Scientist, Laboratory of Pharmacology, Department of Experimental and Clinical Pharmacology, Medical Center, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants, Moscow
K.V. Kolkhir - Dr.Sc. (Med.), Head of Department of Experimental and Clinical Pharmacology, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants, Moscow
T.A. Sokolskaya - Dr. Sc. (Pharm.), Professor, First Deputy of Director, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants, Moscow

The objects of study are the grape red leaves extracts dry, of different varieties of grape (Vitis Vinifera L.) cultivated in the Rostov region. To select the promising variety of the grape red leaves extracts dry for further study to invent a new venotonic medicine the specific enzyme biotest-systems are applied. Glutationreductase, catalase and pyruvate kinase are using in these specific enzyme biotest-systems for detecting compounds with antioxidant, antimicrobial, adaptogenic, energizing and venotonic activities. The different antioxidant and venotonic properties of the different varieties the grape red leaves dry extracts were determined and the more promising variety of these extracts was selected for further study in order to create products with venotonic properties.

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Patent RF №2181890. Sposob vy'yavleniya veshhestv, obladayushhix adaptogenny'mi svojstvami, in vitro / V.A. By'kov, M.F. Mineeva, V.A. Dubinskaya, L.B. Rebrov, V.K. Kolxir.

Patent RF № 2181892. Sposob vy'yavleniya veshhestv, obladayushhix antioksidantny'mi svojstvami, in vitro / V.A. By'kov, V.A. Dubinskaya, M.F. Mineeva, L.B. Rebrov, V.K. Kolxir.

Patent RF №2181891. Sposob vy'yavleniya veshhestv, obladayushhix protivomikrobny'mi i protivovirusny'mi svojstvami, in vitro / V.A. By'kov, M.F. Mineeva, V.A. Dubinskaya, L.B. Rebrov, V.K. Kolxir.

Lupanova I.A. Issledovanie molekulyarny'x mexanizmov dejstviya biologicheski aktivny'x veshhestv na primere triterpenovy'x i flavonoidny'x glikozidov. Avtoreferat dis - kand. biol. nauk. M.: 2012. 25 s.

Lupanova I.A., Mineeva M.F., Kolxir V.K., Strelkova L.B., Sokol'skaya T.A. Primenenie speczificheskix fermentny'x biotest-sistem in vitro dlya issledovaniya biologicheskoj aktivnosti nekotory'x prirodny'x soedinenij // Voprosy' biologicheskoj, mediczinskoj i farmaczevticheskoj ximii. 2012. № 1. S. 172-177.

Dul V.N. Vinograd kul'turny'j ? Vitis vinifera L. Novy'j istochnik makro- i mikroe'lementov // Vestnik VGU. Ser. Geografiya, geoe'kologiya. 2010. № 2. S. 76-78.

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