350 rub
Journal №12 for 2013 г.
Article in number:
Study of the protein aggregates formation in the presence of potassium and europium ions by photon-correlation spectroscopy and atomic-force microscopy
Keywords: serum albumin g-globulin dynamic light scattering photon-correlation spectroscopy atomic-force microscopy aggregation heavy metals
Authors:
T.N. Tikhonova - Post-graduate Student, Department of Molecular Physics, Faculty of Physics, M.V. Lomonosov Moscow State University; Junior Research Scientist, Establishment of the Russian Academy of Sciences the Institute of Microelectronics, Moscow. E-mail: t.n.tikhonova@yandex.ru
G.P. Petrova - Dr.Sc. (Phys.-Math.), Professor, Department of Molecular Physics, Faculty of Physics, M.V. Lomonosov Moscow State University. E-mail: petrova@phys.msu.ru
V.V. Kashin - Research Scientist, V.A. Kotel-nikov Institute of Radio Engineering and Electronics, Russian Academy of Sciences, Moscow. E-mail: vadim_kashin@mail.ru
S.V. Krupenin - Research Scientist, V.A. Kotel-nikov Institute of Radio Engineering and Electronics, Russian Academy of Sciences, Moscow. E-mail: krupenin@cplire.ru
E.M. Eganova - Junior Research Scientist, Establishment of the Russian Academy of Sciences the Institute of Microelectronics, Moscow. E-mail: eganovaem@mail.ru
Abstract:
The aqueous solutions of main blood serum proteins (albumin, g-globulin) containing small concentrations of ions of potassium and europium were investigated with the help of photon-correlation spectroscopy and atomic-force microscopy. The dependence of translation diffusion coefficient values and also effective radiuses of dispersive particles were obtained on pH and salt concentration. It is revealed that in these solutions protein dipole aggregates are formed that is also confirmed by AFM.
Pages: 24-30
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