350 rub
Journal №10 for 2012 г.
Article in number:
Sensitivity of Breast Cancer Cells Cultured in Vitro to Hypoxia: the Role of Estrogen Receptors Machinery
Keywords: breast cancer estrogens estrogen receptor &#945 hypoxia HER2/Neu
Authors:
L.B. Stefanova, A.M. Scherbakov, O.E. Andreeva, N.A. Bolotina, I.V. Tereshkina, M.A. Krasil-nikov
Abstract:
The main goal of the project was to study a relationship between the hormonal responsiveness and the sensitivity of breast cancer cells to hypoxia. Using in vitro cultured breast cancer cells and the assessment of the ERα level in hypoxic conditions the hypoxia-dependent degradation of ERα has been demonstrated. At the same time under hypoxia we have revealed no changes in HER2/Neu (ERBB2) level, the EGF receptors family protein. We have established that the development of estrogen-independent breast cancer cells growth and the corresponding exclusion of ERα from the mitogenic pathways accompany the increase of cells unresponsiveness to hypoxia. In general, the obtained data show that the hypoxia-dependent degradation of estrogen receptor may be considered as one of the factors determining the high sensitivity of estrogen-responsive tumors to hypoxia.
Pages: 60-63
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