Влияние внутрижелудочного введения аспарагината цинка на распределение токсичных микроэлементов в органах и тканях лабораторных животных

Андрей Анатольевич Скальный; Алексей Алексеевич Тиньков; Юлия Сергеевна Медведева; Ирина Борисовна Алчинова; Ольга Павловна Айсувакова; Евгений Юрьевич Бонитенко; Михаил Юрьевич Карганов; Александр Александрович Никоноров; Маргарита Геннадьевна Скальная; Юлия Николаевна Лобанова

Влияние внутрижелудочного введения аспарагината цинка на распределение токсичных микроэлементов в органах и тканях лабораторных животных

Андрей Анатольевич Скальный¹, Алексей Алексеевич Тиньков², Юлия Сергеевна Медведева³, Ирина Борисовна Алчинова⁴, Ольга Павловна Айсувакова⁵, Евгений Юрьевич Бонитенко⁶, Михаил Юрьевич Карганов⁷, Александр Александрович Никоноров⁸, Маргарита Геннадьевна Скальная⁹, Юлия Николаевна Лобанова¹⁰

научная статья Страницы: 17-28

¹ врач, АНО «Центр биотической медицины» (Москва)
² к.м.н., ассистент, ГБОУ ВПО «Оренбургский государственный медицинский университет» Минздрава РФ
³ науч. сотрудник, ФГБУ «НИИ общей патологии и патофизиологии» РАН (Москва)
⁴ науч. сотрудник, ФГБУ «НИИ общей патологии и патофизиологии» РАН
⁵ к.х.н, ассистент, ГБОУ ВПО «Оренбургский государственный педагогический университет»
⁶ д.м.н., профессор, директор, ФГБУН «Институт токсикологии ФМБА» (Санкт-Петербург)
⁷ д.б.н., профессор, зав. лабораторией, ФГБУ «НИИ общей патологии и патофизиологии» РАН (Москва)
⁸ д.м.н., профессор, ГБОУ ВПО «Оренбургский государственный медицинский университет» Минздрава РФ
⁹ д.м.н., профессор, директор АНО «Центр биотической медицины» (Москва)
¹⁰ к.б.н., зам. заведующего кафедрой, КДЛ ООО «Микронутриенты»

Ключевые слова: аспарагинат цинка токсичные микроэлементы ткани животные

Аннотация

Изучено влияние 7- и 14-cуточного внутрижелудочного введения аспарагината цинка в дозировке 5 и 15 мг/кг на распределение токсичных микроэлементов в органах и тканях крыс линии Wistar. Показано, что дозировка 15 мг/кг вызывает более выраженное изменение содержания Zn в печени, почках и сыворотке как на 7-, так и 14-е сутки введения. В отношении изменения содержания токсичных микроэлементов более выраженным влиянием обладала так же дозировка 15 мг/кг, при этом, выявленные изменения были разнонаправленными. Делается заключение о перераспределении токсичных металлов в организме животных под влиянием аспарагината цинка и необходимости дальнейших исследований возможных механизмов реализации данных эффектов.

Для цитирования

Скальный А.А., Тиньков А.А., Медведева Ю.С., Алчинова И.Б., Айсувакова О.П., Бонитенко Е.Ю., Карганов М.Ю., Никоноров А.А., Скальная М.Г., Лобанова Ю.Н. Влияние внутрижелудочного введения аспарагината цинка на распределение токсичных микроэлементов в органах и тканях лабораторных животных // Технологии живых систем. 2015. № 4. С. 17–28.

Список источников

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[1] Agostinho M., Kobayashi S. Strontium-catalyzed highly enantioselective Michael additions of malonates to enones // J. Am. Chem. Soc. 2008. V. 130. Р. 2430-2431.

[2] Albert A. The covalent bond in selective toxicity. In (Albert A., Ed.) Selective toxicity, Springer Netherlands. 1985. P. 550-589

[3] Alissa E.M., Ferns G.A. Heavy metal poisoning and cardiovascular disease // J. Toxicol. 2011. 870125.

[4] Angelusiu M.V., Barbuceanu S.F., Draghici C., Almajan G.L. New Cu (II), Co (II), Ni (II) complexes with aroyl-hydrazone based ligand. Synthesis, spectroscopic characterization and in vitro antibacterial evaluation // Eur. J. Med. Chem. 2010. V. 45. P. 2055-2062.

[5] Bagihalli G.B., Avaji P.G., Patil S.A., Badami P.S. Synthesis, spectral characterization, in vitro antibacterial, antifungal and cytotoxic activities of Co (II), Ni (II) and Cu (II) complexes with 1, 2, 4-triazole Schiff bases // Eur. J. Med. Chem. 2008. V. 43. P. 2639-2649.

[6] Beck M.T., Nagypal I. Complex equilibria: stability constants. New York: Halsted Press. 1989.

[7] Bhasin P., Singla N., Dhawan D.K. Protective role of zinc during aluminum-induced hepatotoxicity // Environ. Toxicol. 2014. V. 29. P. 320-327.

[8] Bray T.M., Bettger W.J. The physiological role of zinc as an antioxidant // Free Radic. Biol. Med. 1990. V. 8. P. 281-91.

[9] Chadha V.D., Bhalla P., Dhawan D.K. Zinc modulates lithium-induced hepatotoxicity in rats // Liver Int. 2008. V. 28. P. 558-565.

[10] Cotton F.A., Wilkinson G., Murillo C.A., Bochmann M. Advances in Inorganic Chemistry. 6th ed. Wiley. New York. 1999

[11] Emsley J. The elements. Clarendon press. Oxford. 1989

[12] Goyer R.A. Toxic and essential metal interactions // Annu. Rev. Nutr. 1997. V. 17. P. 37-50.

[13] Hyman M.A. Environmental toxins, obesity, and diabetes: an emerging risk factor // Altern. Ther. Health Med. 2010. V. 16. P. 56.

[14] Johnson M.A., Greger J.L. Absorption, distribution and endogenous excretion of zinc by rats fed various dietary levels of inorganic tin and zinc // J. Nutr. 1984. V. 114. P. 1843-1852.

[15] Jomova K., Vondrakova D., Lawson M., Valko M. Metals, oxidative stress and neurodegenerative disorders // Mol. Cell Biochem. 2010. V. 345. P. 91-104.

[16] Kowall T., Caravan P., Bourgeois H., Helm L., Rotzinger F.P., Merbach A.E. Interpretation of Activation Volumes for Water Exchange Reactions Revisited: Ab I nitio Calculations for Al3+, Ga3+, and In3+, and New Experimental Data // J. Am. Chem. Soc. 1998. V. 120. P. 6569-6577.

[17] Krahl T., Kemnitz E. The very strong solid Lewis acids aluminiumchlorofluoride (ACF) and bromofluoride (ABF)-Synthesis, structure, and Lewis acidity // J. Fluorine Chem. 2006. V. 127. P. 663-678.

[18] Maldanis R.J., Wood J.S., Chandrasekaran A., Rausch M.D., Chien J.C. The formation and polymerization behavior of Ni (II) α-diimine complexes using various aluminum activators // J. Organomet. Chem. 2002. V. 645. P. 158-167.

[19] Maret W., Vallee B.L. Thiolate ligands in metallothionein confer redox activity on zinc clusters // Proc. Natl. Acad. Sci. USA. 1998. V. 95. P. 3478-3482.

[20] Maret W. The function of zinc metallothionein: a link between cellular zinc and redox state // J. Nutr. 2000. V. 130. P. 1455S-1458S

[21] Matsukura T., Tanaka H. Applicability of zinc complex of L-carnosine for medical use // Biochemistry Mosc. 2000. V. 65. P. 817-823.

[22] Nriagu J.O. A history of global metal pollution // Science. 1996. V. 272. P. 223.

[23] Oliveira D.M., Lacava Z.G., Lima E.C., Morais P.C., Tedesco A.C. Zinc phthalocyanine/magnetic fluid complex: a promising dual nanostructured system for cancer treatment // J. Nanosci. Nanotechnol. 2006. V. 6. P. 2432-2437.

[24] Oliveira J.P., Querido W., Caldas R.J., Campos A.P., Abraçado L.G., Farina M. Strontium is incorporated in different levels into bones and teeth of rats treated with strontium ranelate // Calcified Tissue Int. 2012. V. 91. P. 186-195.

[25] Peraza M.A., Ayala-Fierro F., Barber D.S., Casarez E., Rael L.T. Effects of micronutrients on metal toxicity // Environ. Health Perspect. 1998. V. 106. P. 203.

[26] Powell S.R. The antioxidant properties of zinc // J. Nutr. 2000. V. 130. P. 1447S-54S.

[27] Prasad A.S. Clinical, immunological, anti-inflammatory and antioxidant roles of zinc // Exp. Geront. 2008. V. 43. P. 370-377.

[28] Rezlescu E., Sachelarie L., Popa P.D., Rezlescu N. Effect of substitution of divalent ions on the electrical and magnetic properties of Ni-Zn-Me ferrites // IEEE Trans. Magn. 2000. V. 36. P. 3962-3967.

[29] Ribas J., Escuer A., Monfort M., Vicente R., Cortés R., Lezama L., Rojo T. Polynuclear Ni II and Mn II azido bridging complexes. Structural trends and magnetic behavior // Coord. Chem. Rev. 1999. V. 193. P. 1027-1068.

[30] Roesijadi G. Metal transfer as a mechanism for metallothionein-mediated metal detoxification // Cell Mol. Biol. 2000. V. 46. P. 393-405.

[31] Sakurai H., Adachi Y. The pharmacology of the insulinomimetic effect of zinc complexes // Biometals. 2005. V. 18. P. 319-323.

[32] Shindo H., Brown T.L. Infrared Spectra of Complexes of L-Cysteine and Related Compounds with Zinc (II), Cadmium (II), Mercury (II), and Lead (II) // J. Am. Chem. Soc. 1965. V. 87. P. 1904-1909.

[33] Sidhu P., Garg M.L., Dhawan D.K. Effect of zinc on biological half-lives of 65Zn in whole body and liver and on distribution of 65Zn in different organs of rats following nickel toxicity // Biol. Trace Elem. Res. 2004. V. 102. P. 173-188.

[34] Solov-ev V.P., Kireeva N.V., Tsivadze A.Y., Var-nek A.A. Structure-property modelling of complex formation of strontium with organic ligands in water // J. Struct. Chem. 2006. V. 47. P. 298-311.

[35] Tandon A., Nagpaul J.P., Bandhu H., Singh N., Dhawan D.K. Effect of lithium on hepatic and serum elemental status under different dietary protein regimens // Biol. Trace Elem. Res. 1999. V. 68. P. 51-62.

[36] Thomsen K., Schou M. Renal lithium excretion in man // Am. J. Physiol. 1968. V. 215. P. 823-827.

[37] Valko M., Morris H., Cronin M.T.D. Metals, toxicity and oxidative stress // Current medicinal chemistry. 2005. V. 12(10). P. 1161-1208.

[38] Vallee B.L., Auld D.S. Zinc coordination, function, and structure of zinc enzymes and other proteins // Biochemistry. 1990. V. 29. P. 5647-5659.

[39] Vašák M., Meloni G. Chemistry and biology of mammalian metallothioneins // JBIC J. Biol. Inorg. Chem. 2011. V. 16. P. 1067-1078.

[40] Wiesbrock F., Schmidbaur H. The structural chemistry of lithium, sodium and potassium anthranilate hydrates // J. Chem. Soc., Dalton Trans. 2002. V. 24. P. 4703-4708.

[41] Xin F., Pope M.T. Lone-Pair-Induced Chirality in Polyoxotungstate Structures: Tin (II) Derivatives of A-Type XW9O34 n-(X= P, Si). Interaction with Amino Acids // J. Am. Chem. Soc. 1996. V. 118. P. 7731-7736.

[42] Zhao L.J., Ren T., Zhong R.G. Determination of lead in human hair by high resolution continuum source graphite furnace atomic absorption spectrometry with microwave digestion and solid sampling // Analyt. Lett. 2012. V. 45. P. 2467-81.

[43] Zou M.H., Shi C., Cohen R.A. Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite // J. Clin. Invest. 2002. V. 109. P. 817-826.

Аннотация

Для цитирования

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