Gstm1: иметь или не иметь?

Л.Е. Сальникова; Т.И. Иванова; Т.В. Кондрашова; Э.А. Акаева; Т.В. Елисова; И.Н. Веснина; Н.Ш. Лаптева; А.Г. Чумаченко; Г.И. Кузнецова; А.В. Рубанович

Gstm1: иметь или не иметь?

Л.Е. Сальникова¹, Т.И. Иванова², Т.В. Кондрашова³, Э.А. Акаева⁴, Т.В. Елисова⁵, И.Н. Веснина⁶, Н.Ш. Лаптева⁷, А.Г. Чумаченко⁸, Г.И. Кузнецова⁹, А.В. Рубанович¹⁰

научная статья Страницы: 31-38

Ключевые слова: хромосомные аберрации полиморфизм ДНК детоксикация ксенобиотиков

Аннотация

Представлены две группы данных по ассоциациям нормального функционального генотипа GSTM1: 1) с заболеваниями женской репродуктивной сферы; 2) с частотой спонтанных хромосомных аберраций в лимфоцитах крови здоровых добровольцев до 25 лет. В обоих случаях мы наблюдали протективный характер действия «нулевых» генотипов GSTM1

Для цитирования

Сальникова Л.Е., Иванова Т.И., Кондрашова Т.В., Акаева Э.А., Елисова Т.В., Веснина И.Н., Лаптева Н.Ш., Чумаченко А.Г., Кузнецова Г.И., Рубанович А.В. Gstm1: иметь или не иметь? // Технологии живых систем. 2009. № 2. С. 31–38.

Список источников

Баранов В.С., Баранова Е.В., Иващенко Т.Э., Асеев М.В. Геном человека и гены «предрасположенности». Введение в предикативную медицину. СПб.: Интермедика. 2000.
Сальникова Л.Е., Фомин Д.К., Елисова Т.В. и др. Изучение связи цитогенетических и эпидемиологических показателей с генотипами у ликвидаторов последствий аварии на ЧАЭС // Радиационная биология. Радиоэкология. 2008. Т.48. № 3. С. 303-312.
Vogl F.D., Taioli E., Maugard C., et al. Glutathione S-transferases M1, T1, and P1 and Breast Cancer: A Pooled Analysis // Cancer Epidemiol Biomarkers Prev. 2004. Vol. 13(9).
da Fonte L.A., Rossini A., Mendonca G., et al. CYP1A1, GSTM1, and GSTT1 polymorphisms and breast cancer risk in Brazilian women // Cancer Lett. 2002. Vol. 181. P. 179-186.
Zheng W., Wen W.Q., Gustafson D.R., et al. GSTM1 and GSTT1 polymorphisms and postmenopausal breast cancer risk // Breast Cancer Res. Treat. 2002. Vol. 74. P. 9 - 16.
Siraj A.K., Ibrahim M., Al-Rasheed M., et al. Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population // BMC Med. Genet. 2008. V.9. V.61.
Raimondi S., Boffetta P., Anttila S., et al. Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study // Mutat. Res. 2005. V. 592. N. 1-2. P. 45 - 57.
Marcon F., Andreoli C., Rossi S., et al. Assessment of individual sensitivity to ionizing radiation and DNA repair efficiency in a healthy population // Mutat. Res. 2003. V. 541. N. 1-2. P. 1 -8.
Iarmarcovai G., Sari-Minodier I., Orsiere T., et al. Acombined analysis of XRCC1, XRCC3, GSTM1 and GSTT1polymorphisms and centromere content of micronuclei in welders // Mutagenesis. 2006. V. 21. N. 2. P.159 - 165.
Gago-Dominguez M., Jiang X. Castelao J.E. Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis // Breast Cancer Research. 2007. V. 9. P. 201.
Brennan P., Hsu C.C. , Moullan N., et al. Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach // The Lancet. 2005. V. 366. P. 1558-1560.
Gaudet M.M., Olshan A.F., Poole C., et al. Diet, GSTM1 and GSTT1 and head and neck cancer // Carcinogenesis. 2004. Vol. 25. N. 5. P. 735-740.
Palli D., Masala G., Peluso M., et al. The effects of diet on DNA bulky adduct levels are strongly modified by GSTM1 genotype: a study on 634 subjects // Carcinogenesis. 2004. Vol. 25. N. 4. P. 577-584.
Reszka E., Wasowicz W., Gromadzinska J. Genetic polymorphism of xenobiotic metabolising enzymes, diet and cancer susceptibility // Br. J. Nutr. 2006. V. 96. N. 4. P. 609-619.
Tseng E., Scott-Ramsay E.A., Morris M.E. Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines // Exp. Biol. Med. 2004. V. 229. P. 835-842.
Sorensen M., Raaschou-Nielsena O., Brasch-Andersenb C., et al. Interactions between GSTM1, GSTT1 and GSTP1polymorphisms and smoking and intake of fruit and vegetables in relation to lung cancer // Lung Cancer. 2007. V. 55. P. 137-144.
Patent № 0060194200 (US).
Roodi N., Dupont W.D., Moore J.H., et al. Association of homozygous wild-type glutathione S-transferase M1 genotype with increased breast cancer risk // Cancer Res. 2004. V. 64. P. 1233-1236.
Godschalk R.W., Ostertag J.U., Zandsteeg A.M., et al. Impact of GSTM1 on aromatic-DNA adducts and p53 accumulation in human skin and lymphocytes // Pharmacogenetics. 2001. V.11. N. 6. P. 537-543.
Song J.J., Lee Y.J. Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1 // Biochem. J., 2003. V. 373. P. 845-853.
Dorion S., Lambert H., Landry J. Activation of the 38 signaling pathway by heat shock involves the dissociation of glutathione S-transferase Mu from Ask1 // The Journal of Biological Chemistry. 2002. V. 277. N. 34. P. 30792-30797.
Hayes J.D., Strange R.C. Glutathione S-Transferase polymorphisms and their biological consequences // Pharmacology. 2000. V. 61. P. 154-166.
Kirsch-Volders M., Mateuca R. A., Roelants M., et al. The Effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivo // Cancer Epidemiol Biomarkers Prev. 2006. V. 15. P. 1038-1042.
Reszka E., Wasowicz W., Gromadzinska J. Antioxidant defense markers modulated by glutathione S-transferase genetic polymorphism: results of lung cancer case-control study // Genes Nutr. 2007. V. 2. P. 287-294.
Shi-jie Xu, Ying-ping Wang, B. Roe, Pearson W.R. Characterization of the Human Class Mu Glutathione S-Transferase Gene Cluster and the GSTM1 Deletion // Journal of Biological Chemistry. 1998. V. 273. N. 6. P. 3517-3527.
Ye Z., Song H., Higgins J. P. T., et al. Five glutathione S-transferase genevariants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studies // PLoS Medicine. 2006. V. 3. Issue 4. P. 91.
Houlston R. S. Glutathione S-transferase M1 status and lung cancer risk: a meta-analysis // Cancer Epidemiology, Biomarkers & Prevention. 1999. V. 8. P. 675-682.
Dunning A. M., Healey C. S., Pharoah P. D. P., et al. A systematic review of genetic polymorphisms and breast cancer risk // Biomarkers & Prevention. 1999. V. 8. P. 843-854.

[1] Баранов В.С., Баранова Е.В., Иващенко Т.Э., Асеев М.В. Геном человека и гены «предрасположенности». Введение в предикативную медицину. СПб.: Интермедика. 2000.

[2] Сальникова Л.Е., Фомин Д.К., Елисова Т.В. и др. Изучение связи цитогенетических и эпидемиологических показателей с генотипами у ликвидаторов последствий аварии на ЧАЭС // Радиационная биология. Радиоэкология. 2008. Т.48. № 3. С. 303-312.

[3] Vogl F.D., Taioli E., Maugard C., et al. Glutathione S-transferases M1, T1, and P1 and Breast Cancer: A Pooled Analysis // Cancer Epidemiol Biomarkers Prev. 2004. Vol. 13(9).

[4] da Fonte L.A., Rossini A., Mendonca G., et al. CYP1A1, GSTM1, and GSTT1 polymorphisms and breast cancer risk in Brazilian women // Cancer Lett. 2002. Vol. 181. P. 179-186.

[5] Zheng W., Wen W.Q., Gustafson D.R., et al. GSTM1 and GSTT1 polymorphisms and postmenopausal breast cancer risk // Breast Cancer Res. Treat. 2002. Vol. 74. P. 9 - 16.

[6] Siraj A.K., Ibrahim M., Al-Rasheed M., et al. Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population // BMC Med. Genet. 2008. V.9. V.61.

[7] Raimondi S., Boffetta P., Anttila S., et al. Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study // Mutat. Res. 2005. V. 592. N. 1-2. P. 45 - 57.

[8] Marcon F., Andreoli C., Rossi S., et al. Assessment of individual sensitivity to ionizing radiation and DNA repair efficiency in a healthy population // Mutat. Res. 2003. V. 541. N. 1-2. P. 1 -8.

[9] Iarmarcovai G., Sari-Minodier I., Orsiere T., et al. Acombined analysis of XRCC1, XRCC3, GSTM1 and GSTT1polymorphisms and centromere content of micronuclei in welders // Mutagenesis. 2006. V. 21. N. 2. P.159 - 165.

[10] Gago-Dominguez M., Jiang X. Castelao J.E. Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis // Breast Cancer Research. 2007. V. 9. P. 201.

[11] Brennan P., Hsu C.C. , Moullan N., et al. Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach // The Lancet. 2005. V. 366. P. 1558-1560.

[12] Gaudet M.M., Olshan A.F., Poole C., et al. Diet, GSTM1 and GSTT1 and head and neck cancer // Carcinogenesis. 2004. Vol. 25. N. 5. P. 735-740.

[13] Palli D., Masala G., Peluso M., et al. The effects of diet on DNA bulky adduct levels are strongly modified by GSTM1 genotype: a study on 634 subjects // Carcinogenesis. 2004. Vol. 25. N. 4. P. 577-584.

[14] Reszka E., Wasowicz W., Gromadzinska J. Genetic polymorphism of xenobiotic metabolising enzymes, diet and cancer susceptibility // Br. J. Nutr. 2006. V. 96. N. 4. P. 609-619.

[15] Tseng E., Scott-Ramsay E.A., Morris M.E. Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines // Exp. Biol. Med. 2004. V. 229. P. 835-842.

[16] Sorensen M., Raaschou-Nielsena O., Brasch-Andersenb C., et al. Interactions between GSTM1, GSTT1 and GSTP1polymorphisms and smoking and intake of fruit and vegetables in relation to lung cancer // Lung Cancer. 2007. V. 55. P. 137-144.

[17] Patent № 0060194200 (US).

[18] Roodi N., Dupont W.D., Moore J.H., et al. Association of homozygous wild-type glutathione S-transferase M1 genotype with increased breast cancer risk // Cancer Res. 2004. V. 64. P. 1233-1236.

[19] Godschalk R.W., Ostertag J.U., Zandsteeg A.M., et al. Impact of GSTM1 on aromatic-DNA adducts and p53 accumulation in human skin and lymphocytes // Pharmacogenetics. 2001. V.11. N. 6. P. 537-543.

[20] Song J.J., Lee Y.J. Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1 // Biochem. J., 2003. V. 373. P. 845-853.

[21] Dorion S., Lambert H., Landry J. Activation of the 38 signaling pathway by heat shock involves the dissociation of glutathione S-transferase Mu from Ask1 // The Journal of Biological Chemistry. 2002. V. 277. N. 34. P. 30792-30797.

[22] Hayes J.D., Strange R.C. Glutathione S-Transferase polymorphisms and their biological consequences // Pharmacology. 2000. V. 61. P. 154-166.

[23] Kirsch-Volders M., Mateuca R. A., Roelants M., et al. The Effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivo // Cancer Epidemiol Biomarkers Prev. 2006. V. 15. P. 1038-1042.

[24] Reszka E., Wasowicz W., Gromadzinska J. Antioxidant defense markers modulated by glutathione S-transferase genetic polymorphism: results of lung cancer case-control study // Genes Nutr. 2007. V. 2. P. 287-294.

[25] Shi-jie Xu, Ying-ping Wang, B. Roe, Pearson W.R. Characterization of the Human Class Mu Glutathione S-Transferase Gene Cluster and the GSTM1 Deletion // Journal of Biological Chemistry. 1998. V. 273. N. 6. P. 3517-3527.

[26] Ye Z., Song H., Higgins J. P. T., et al. Five glutathione S-transferase genevariants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studies // PLoS Medicine. 2006. V. 3. Issue 4. P. 91.

[27] Houlston R. S. Glutathione S-transferase M1 status and lung cancer risk: a meta-analysis // Cancer Epidemiology, Biomarkers & Prevention. 1999. V. 8. P. 675-682.

[28] Dunning A. M., Healey C. S., Pharoah P. D. P., et al. A systematic review of genetic polymorphisms and breast cancer risk // Biomarkers & Prevention. 1999. V. 8. P. 843-854.