Fractional composition research and balm fabrication on the basis of the dead sea mud

Л.И. Бутенко; С.А. Кулешова; Н.В. Постникова; В.Г. Матаева; И.Я. Куль

Fractional composition research and balm fabrication on the basis of the dead sea mud

Л.И. Бутенко¹, С.А. Кулешова², Н.В. Постникова³, В.Г. Матаева⁴, И.Я. Куль⁵

research article Pages: 13-17

¹ к.х.н., кафедра органической химии, Пятигорский медико-фармацевтический институт - филиал ГБОУ ВПО ВолгГМУ. E-mail: Polechka2802@ yandex.ru
² к.фарм.н., доцент, кафедра фармакологии с курсом клинической фармакологии, Пятигорский медико-фармацевтический институт - филиал ГБОУ ВПО ВолгГМУ
³ к.б.н., ст. преподаватель, кафедра биохимии и микробиологии, Пятигорский медико-фармацевтический институт - филиал ГБОУ ВПО ВолгГМУ
⁴ интерн, Пятигорский медико-фармацевтический институт - филиал ГБОУ ВПО ВолгГМУ
⁵ к.фарм.н., доцент, кафедра фармацевтической и токсикологической химии, Пятигорский медико-фармацевтический институт - филиал ГБОУ ВПО ВолгГМУ

Keywords: balm on the basis of Dead sea mud peloids UV- and IR-spectral of peload fraction antibacterial wound healing activity acute toxicity

Abstract

The Dead Sea mud is a unique source with the richest fount of biologically active compounds. In addition to rich mineral content, the Dead sea mud have an original organic component. Fabrication of pharmaceutical products, which preserve all the properties of natural mud, makes it possible to increases the application of peloid therapy for balneological and home use. From the Dead sea mud we obtained a peloid fraction and an oil balm. For the peloid faction it was determined UV and IR spectral characteristics. UV spectral data can be used for Dead sea mud drugs standardization. It was established that the antibacterial action is typical for the Dead sea mud and scraps. According to the obtained data and investigation results we can conclude that the antibacterial effect is due to mineral composition. Scraps antibacterial activity is similar to the bactericidal effect of the mud. It can be recommended as mud applications. It was ascertained the healing activity of the balsam obtained from the Dead sea mud on the animal-s linear wounds model. The wounds healing time with the experimental balm is decreased by 25 % compared to the control group result, and it is comparable with the effect of the reference preparation (Tambukan mud oil extract).

How to cite

Бутенко Л.И., Кулешова С.А., Постникова Н.В., Матаева В.Г., Куль И.Я. Комплексное исследование грязи Мертвого моря // Вопросы биологической, медицинской и фармацевтической химии. 2015. № 2. С. 13–17.

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[3] Ingber A. Medicine is flourishing at the Dead Sea // Isr. Med. Assoc. J. 2006. V. 8. № 7. R. 499-500.

[4] Kuxina N., Cy'b A., Bardishhev M. i dr. Bioantioksidanty' Mertvogo morya v kachestve sredstva lecheniya radiaczionnoj patologii // Nauka, obrazovanie, kul'tura. 1997. № 1. S. 36-37.

[5] Mironov A.N., Bunatyan N.D. i dr. Rukovodstvo po provedeniyu doklinicheskix issledovanij lekarstvenny'x sredstv (Ch. I). M.: Iz-vo Grif i K God. 2012. S. 944.

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[7] Patent 2147887 (RF). Sposob polucheniya konczentrata iz Tambukanskoj lechebnoj gryazi (nativnoj) / X.G. Karagulov, I.F. Shherbak.

[8] Karagulov X.G., Moskalenko S.V. Razrabotka i issledovanie spirtovogo e'kstrakta, poluchennogo na osnove peloidov Tambukanskogo ozera: Materialy' nauch. kongr. 27-29 sentyabrya 2000 g. // Tradiczionnaya mediczina (E'lista). 2000. S. 250-252.

[9] Orlov D.S., Osipova N.N. Oczenka otnositel'noj ustojchivosti guminovy'x veshhestv po e'lektronny'm i molekulyarny'm spektram // Guminovy'e veshhestva v biosfere. M.: Nauka. 1993. S. 227-232.

[10] Butenko L.I., Kuleshova S.A., Postnikova N.V., Lovyagina S.A. The «Ajuga genevensis L.» chemical composition and the biological activity study // European journal of natural history. 2011. № 5. R. 31-33.

[11] Butenko L.I., Kuleshova S.A., Postnikova N.V., Kunak E.I. The «Brassica napus L. schrot» chemical composition and the biological activity research // European journal of natural history. 2011. № 5. R. 33-36.