Estimation of influence of the 4-chlorphenyl-2-hydroxy-4-oxo-2-butenoate thiazolineammonium on hemostasis in rabbits and mice at intragastric introduction
- 1 Ph.D. (Med.), Senior Lecturer, Department of Physiology and Pathology, Perm State Pharmaceutical Academy
- 2 Dr. Sc. (Med.), Professor, Head of the Department of Physiology and Pathology, Perm State Pharmaceutical Academy
- 3 Ph.D. (Pharm.), Senior Lecturer, Department of Pharmaceutical Technology, Perm State Pharmaceutical Academy
- 4 Dr. Sc. (Pharm.), Professor, Head of the Department of Pharmaceutical Technology, Perm State Pharmaceutical Academy
Abstract
The goal was to study the influence of the 4-chlorophenyl-2-hydroxy-4-oxo-2 - butenoatethiazoline ammonium(FS 169) on blood clotting intragastric introduction of rabbits, the duration of bleeding and on the development of the simulated acute thrombosis of intragastric introduction mice.
The findings indicate that the substance FS 169 refers to the toxicity class 3, i.e. it is moderately toxic. Has the effect of intragastric introduction. Operates in the body rabbits and mice. Enough is rapidly absorbed. The most pronounced effect on the collapse of whole blood intragastric introduction celebrated for over 30 minutes after the connection. Substance slows blood clotting. The duration of effect connection FS 169 intragastric introduction persists for 2 hours. Significantly reduces the development of acute thrombosis at intravenous introduction of thrombin. Therefore, this material is promising for further in-depth research.
How to cite
Старкова А.В., Сыропятов Б.Я., Собин Ф.В., Пулина Н.А. Оценка влияния 4-хлорфенил-2-гидрокси-4-оксо-2-бутеноата тиазолинаммония на показатели гемостаза у кроликов и мышей при внутрижелудочном введении // Вопросы биологической, медицинской и фармацевтической химии. 2014. № 9. С. 18–21.
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