Analgesic properties of propofol

А.Ю. Елизаров; Д.Г. Герасимов

Analgesic properties of propofol

А.Ю. Елизаров¹, Д.Г. Герасимов²

research article Pages: 72-76

¹ д.ф.-м.н., вед. науч. сотрудник, руководитель группы, Физико-технический институт им. А.Ф. Иоффе РАН (Санкт-Петербург)
² адъюнкт, кафедра анестезиологии и реаниматологии, Военно-медицинская академия им. С.М. Кирова (Санкт-Петербург)

Keywords: propofol mass-spectrometer anesthesia stress-reaction pine respiratory coefficient

Abstract

The results of clinical trials of analgesic properties of propofol method of assessing stress reaction of the patient during propofol - fentanyl anesthesia. The comparison of methods to assess the stress response of the patient based on a precision measurement of the respiratory quotient, electroencephalography methods (bispectral index, auditory evoked potentials ) during prostatectomy pituitary gland. It is shown that propofol has analgesic properties when the blood concentration of more than 3 mg/ml.

How to cite

Елизаров А.Ю., Герасимов Д.Г. Анальгетические свойства пропофола // Вопросы биологической, медицинской и фармацевтической химии. 2014. № 11. С. 72–76.

References

Smit J., Uajt P. Total'naya vnutrivennaya anesteziya // M.: Binom, 2006. 172 s.
Urwyler A., Koppert W.,Ruppen W. Analgesic and Antihyperalgesic Properties of Propofol in a Human Pain Model. // Anesthesiology 2010; Vol.113, P.421.
Elizarov A.Ju., Kozlovskij A.V,, Tupiczy'n I.I., Faizov I.I. Mass-spektrometricheskij monitoring adekvatnosti anestezii // Byulleten' e'ksperimental'noj biologii i medicziny'. 2013. T. 155. № 6. S. 780.
Elizarov A.Ju., Levshankov A.I. Mass-spektrometricheskoe issledovanie soderzhaniya vnutrivenny'x anestetikov v dy'xatel'nom konture apparata ingalyaczionnoj anestezii // ZhTF. 2011. T. 81. Vy'p. 4. S. 155.
Schubert J. K., Spittler K. H., Braun G., Geiger K., Guttmann J. CO2-controlled sampling of alveolar gas in mechanically ventilated patients // J Appl Physiol. 2001. V. 90. P. 486.
Aver'yanov D.A., Cherebillo V.Ju., Shatalov V.I., Shhegolev A.V. Oczenka vliyaniya na vy'razhennost' stress-reakczii obshhej kombinirovannoj i sochetannoj anestezij pri transfenoidal'ny'x udaleniyax opuxolej adenogipofiza // E'fferentnaya terapiya. 2010. T. 16. № 3. S. 58.
Kreuer S., Bruhn J., Larsen R., Hoepstein M., Wilhelm W. Comparison of Alaris AER index and bisrectral index during propofol-remofentanilanaesthesia // British Journal of Anaesthesia. 2003. V. 91. № 3. P. 336.
Elizarov A.Ju., Levshankov A.I., Faizov I.I., Shhegolev A.V. Metod kontrolya bolevoj reakczii na xirurgicheskuyu stimulyacziyu v rezhime real'nogo vremeni // Trudy' mezhdunarodnogo simpoziuma po problemam boli. 22-24.08 2012. SPb.: S. 42.

[1] Smit J., Uajt P. Total'naya vnutrivennaya anesteziya // M.: Binom, 2006. 172 s.

[2] Urwyler A., Koppert W.,Ruppen W. Analgesic and Antihyperalgesic Properties of Propofol in a Human Pain Model. // Anesthesiology 2010; Vol.113, P.421.

[3] Elizarov A.Ju., Kozlovskij A.V,, Tupiczy'n I.I., Faizov I.I. Mass-spektrometricheskij monitoring adekvatnosti anestezii // Byulleten' e'ksperimental'noj biologii i medicziny'. 2013. T. 155. № 6. S. 780.

[4] Elizarov A.Ju., Levshankov A.I. Mass-spektrometricheskoe issledovanie soderzhaniya vnutrivenny'x anestetikov v dy'xatel'nom konture apparata ingalyaczionnoj anestezii // ZhTF. 2011. T. 81. Vy'p. 4. S. 155.

[5] Schubert J. K., Spittler K. H., Braun G., Geiger K., Guttmann J. CO2-controlled sampling of alveolar gas in mechanically ventilated patients // J Appl Physiol. 2001. V. 90. P. 486.

[6] Aver'yanov D.A., Cherebillo V.Ju., Shatalov V.I., Shhegolev A.V. Oczenka vliyaniya na vy'razhennost' stress-reakczii obshhej kombinirovannoj i sochetannoj anestezij pri transfenoidal'ny'x udaleniyax opuxolej adenogipofiza // E'fferentnaya terapiya. 2010. T. 16. № 3. S. 58.

[7] Kreuer S., Bruhn J., Larsen R., Hoepstein M., Wilhelm W. Comparison of Alaris AER index and bisrectral index during propofol-remofentanilanaesthesia // British Journal of Anaesthesia. 2003. V. 91. № 3. P. 336.

[8] Elizarov A.Ju., Levshankov A.I., Faizov I.I., Shhegolev A.V. Metod kontrolya bolevoj reakczii na xirurgicheskuyu stimulyacziyu v rezhime real'nogo vremeni // Trudy' mezhdunarodnogo simpoziuma po problemam boli. 22-24.08 2012. SPb.: S. 42.

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