Pathogenetic relations between long chain fatty acids' metabolism and cytokine profile in the affected areas of skin in psoriasis

T.M. Karavaeva; B.S. Khyshiktuev; E.V. Fal'co; P.P. Tereshkov; M.V. Maksimenya; E.E. Gergesova; O.K. Plotnikova

Pathogenetic relations between long chain fatty acids' metabolism and cytokine profile in the affected areas of skin in psoriasis

T.M. Karavaeva¹, B.S. Khyshiktuev², E.V. Fal'co³, P.P. Tereshkov⁴, M.V. Maksimenya⁵, E.E. Gergesova⁶, O.K. Plotnikova⁷

research article Pages: 65-70

¹ Ph.D. (Med.), Department of Chemistry and Biochemistry, Chita State Medical Academy, Associate Professor of Department
² D.Sc. (Med.), Professor, Department of Chemistry and Biochemistry, Chita State Medical Academy
³ Ph.D. (Med.), Associate Professor, Department of Dermatology and Venereology, Chita State Medical Academy
⁴ Ph.D. (Med.), Head of the Laboratory of Clinical and Experimental Biochemistry and Immunology Research Institute medekologii, Chita State Medical Academy
⁵ Ph.D. (Biol.), Research, Scientist Laboratory of Clinical and Experimental Biochemistry and Immunology Research Institute medekologii, Chita State Medical Academy
⁶ Ph.D., (Med.), Government Institution of Public Health Territorial Children-s Consultive-diagnostic Centre, Laboratory Doctor
⁷ Assistant, Department of Chemistry and Biochemistry, Chita State Medical Academy

Keywords: psoriasis skin long chain fatty acids cytokines

Abstract

The spectra of long chain fatty acids (LCFA) and cytokines in a diseased skin in patients with psoriasis were studied. Imbalance in the spectrum of LCFA identified. It was characterized by a deficit of polyene acids on the background of increasing levels of saturated analogs, mainly with an odd number of carbon atoms, and monoene compounds. The shift of cytokine profile in the direction of proinflammatory (IL-1β, IL-8, TNF-α, IFN-α) and mytogene factors on the background of stable values of anti-inflammatory cytokine IL-4 revealed. We determined significant direct correlations between the level of IL-1β and numbers C20:5ω3.

How to cite

Караваева Т.М., Хышиктуев Б.С., Фалько Е.В., Терешков П.П., Максименя М.В., Гергесова Е.Е., Плотникова О.К. Патогенетические взаимосвязи обмена высших жирных кислот и цитокинового профиля в пораженных участках кожи при псориазе // Вопросы биологической, медицинской и фармацевтической химии. 2014. № 1. С. 65–70.

References

Agapova Ju.R. Zakonomernosti izmenenij tkanevogo fosfolipidnogo i zhirnokislotnogo statusa pri rake legkogo: avtoref. dis. ? kand. med. nauk. Chita. 2000. 22 s.
Kornilov A.B. Patogeneticheskoe obosnovanie primeneniya giperbaricheskoj oksigenaczii v terapii psoriaza: avtoref. dis. - kand. med. nauk.. Kornilov. - Chita, 2002. ? 20 s.
Lizenko M.V., Regerand T.I., Baxirev A.M., Petrovskij V.I. // Voprosy' biologicheskoj, mediczinskoj i farmaczevticheskoj ximii. 2005. № 4. S. 49-54.
Rasulov M.M., Bobkova S.N., Belikova O.A., Nurbekov M.K., Eroxina E.V., Voronkov M.G. // Voprosy' biologicheskoj, mediczinskoj i farmaczevticheskoj ximii. 2012. №3. S. 55-58.
Sinyak K.M., Orgel' M.Ja., Kruk V.I. // Laboratornoe delo. 1976. № 1. C. 37-41.
Titov V.N. // Klinicheskaya laboratornaya diagnostika. 2006. № 11. S. 3-12.
Xy'shiktuev B.S. Rol' narushenij metabolizma lipidov v patogeneze i diagnostike zabolevanij organov dy'xaniya: avtoref. dis. - d-ra med. nauk. Irkutsk. 1995. 42 s.
Cherepkova O.A., Lyutova E.M., Gurvicz B.Ja. // Bioximiya. 2006. T. 71. № 1. S. 90-96.
Dobryniewski J. // Przegl. Lek. 2007. V. 64. № 2. P. 91-99.
Folch J., Less M., Sloane-Stanley A.G.H. // J. Biol. Chem. 1957. V. 226. P. 497-509.
Gani O.A. // Cardiovasc. Diabetol. 2008. V. 20. № 7. P. 6-8.
Hack K., Reilly L., Palmer C. // PLoS One. 2012. V. 7(5). P. e37097. P. 1-11.
Icre G, Wahli W, Michalik L. // J. Invest. Dermatol. 2006. V. 126. P. 30-35.
Khnykin D., Miner J.H. , Jahnsen F. // Dermatoendocrinol. 2011. V. 3(2). P. 53-61.
Man M. // J. of Invest. Dermatol. 2008. V. 128. P. 370-377.
Michalik L., Wahli W. // Biochim. Biophys. Acta. 2007. V. 177. № 8. P. 991-998.
Miles E.A., Calder P.C. // J. Nutr. 2012. V. 107(2). P. 171-84.
Monk J.M., Kim W., Callaway E. // J Physiol Gastrointest Liver Physiol. 2012. V. 302(1). P. G153-67.
Ramon S., Gao F., Serhan C.N., Phipps R.P. // J. Immunol. 2012. V. 189(2). P. 1036-42.
Romanowska M. // J. of Invest. Dermatol. 2008. V. 128. P. 110-124.
Schon M.P., Boehncke W.H. // N. Engl. J. Med. 2005. V. 352. P. 1899-1912.
Sheng W., Zong Y., Mohammad A., Ajit D., Cui J., Han D., Hamilton J.L., Simonyi A., Sun A.Y., Gu Z., Hong J.S., Weisman G.A., Sun G.Y. // J Neuroinflammation. 2011. V. 8:121. doi:10.1186/1742-2094-8-121.
Stempelj M. // J. Biol. Chem. 2007. V. 282. № 13. P. 9797-9804.
Zaba L.S. // J. of Invest. Dermatol. 2009. V. 129. P. 79-88.

[1] Agapova Ju.R. Zakonomernosti izmenenij tkanevogo fosfolipidnogo i zhirnokislotnogo statusa pri rake legkogo: avtoref. dis. ? kand. med. nauk. Chita. 2000. 22 s.

[2] Kornilov A.B. Patogeneticheskoe obosnovanie primeneniya giperbaricheskoj oksigenaczii v terapii psoriaza: avtoref. dis. - kand. med. nauk.. Kornilov. - Chita, 2002. ? 20 s.

[3] Lizenko M.V., Regerand T.I., Baxirev A.M., Petrovskij V.I. // Voprosy' biologicheskoj, mediczinskoj i farmaczevticheskoj ximii. 2005. № 4. S. 49-54.

[4] Rasulov M.M., Bobkova S.N., Belikova O.A., Nurbekov M.K., Eroxina E.V., Voronkov M.G. // Voprosy' biologicheskoj, mediczinskoj i farmaczevticheskoj ximii. 2012. №3. S. 55-58.

[5] Sinyak K.M., Orgel' M.Ja., Kruk V.I. // Laboratornoe delo. 1976. № 1. C. 37-41.

[6] Titov V.N. // Klinicheskaya laboratornaya diagnostika. 2006. № 11. S. 3-12.

[7] Xy'shiktuev B.S. Rol' narushenij metabolizma lipidov v patogeneze i diagnostike zabolevanij organov dy'xaniya: avtoref. dis. - d-ra med. nauk. Irkutsk. 1995. 42 s.

[8] Cherepkova O.A., Lyutova E.M., Gurvicz B.Ja. // Bioximiya. 2006. T. 71. № 1. S. 90-96.

[9] Dobryniewski J. // Przegl. Lek. 2007. V. 64. № 2. P. 91-99.

[10] Folch J., Less M., Sloane-Stanley A.G.H. // J. Biol. Chem. 1957. V. 226. P. 497-509.

[11] Gani O.A. // Cardiovasc. Diabetol. 2008. V. 20. № 7. P. 6-8.

[12] Hack K., Reilly L., Palmer C. // PLoS One. 2012. V. 7(5). P. e37097. P. 1-11.

[13] Icre G, Wahli W, Michalik L. // J. Invest. Dermatol. 2006. V. 126. P. 30-35.

[14] Khnykin D., Miner J.H. , Jahnsen F. // Dermatoendocrinol. 2011. V. 3(2). P. 53-61.

[15] Man M. // J. of Invest. Dermatol. 2008. V. 128. P. 370-377.

[16] Michalik L., Wahli W. // Biochim. Biophys. Acta. 2007. V. 177. № 8. P. 991-998.

[17] Miles E.A., Calder P.C. // J. Nutr. 2012. V. 107(2). P. 171-84.

[18] Monk J.M., Kim W., Callaway E. // J Physiol Gastrointest Liver Physiol. 2012. V. 302(1). P. G153-67.

[19] Ramon S., Gao F., Serhan C.N., Phipps R.P. // J. Immunol. 2012. V. 189(2). P. 1036-42.

[20] Romanowska M. // J. of Invest. Dermatol. 2008. V. 128. P. 110-124.

[21] Schon M.P., Boehncke W.H. // N. Engl. J. Med. 2005. V. 352. P. 1899-1912.

[22] Sheng W., Zong Y., Mohammad A., Ajit D., Cui J., Han D., Hamilton J.L., Simonyi A., Sun A.Y., Gu Z., Hong J.S., Weisman G.A., Sun G.Y. // J Neuroinflammation. 2011. V. 8:121. doi:10.1186/1742-2094-8-121.

[23] Stempelj M. // J. Biol. Chem. 2007. V. 282. № 13. P. 9797-9804.

[24] Zaba L.S. // J. of Invest. Dermatol. 2009. V. 129. P. 79-88.

Abstract

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