New polysulfones and their protection effects of gastric ulcers
- 1 к.б.н., мл. науч. сотрудник, лаборатория молекулярной инженерии, Институт биохимии им. А.Н. Баха РАН
- 2 к.т.н., доцент, кафедра «Технология молока и молочных продуктов», Московский государственный университет пищевых производств
- 3 д.х.н., профессор, кафедра химической энзимологии, химический факультет, Московский государственный университет им. М.В. Ломоносова; зав. лабораторией молекулярной инженерии, Институт биохимии им. А.Н. Баха РАН
- 4 д.б.н., вед. науч. сотрудник, профессор, лаборатория молекулярной инженерии, Институт биохимии им. А.Н. Баха РАН; профессор, кафедра технологии молока и молочных продуктов, Московский государственный университет пищевых производств
Abstract
In the model of acute ulcers induced by acid ethanol, showing a protective effect of a dose-dependent α-LA and its tryptic hydrolyzate. Effect hydrolysates significantly higher than the native protein and is dependent on proteolytic exposure process. The most pronounced anti-ulcer effect in experiments with animals (rats) showed low molecular weight peptides derived from proteolysis long.
Caused in an experimental model of acidified ethanol necrotic damage in the gastric mucosa was less or absent if the stomach 30 minutes before initiation of ulcers treated hydrolysates α-LA. The corresponding absolute patronage ulcer damage - the dose was for the native α-LA 280 mg / kg, for the most effective low molecular weight hydrolyzate III α-LA 2 mg / kg body weight of the animal. There is reason to believe that an important role in the mechanism of the protective action of peptides α-LA playing their antioxidant properties. Research has shown that during proteolysis α-LA formed hydrolysates antioxidant activity which correlates with their antiulcer effectiveness.
How to cite
Самохина Л.С., Ионова И.И., Тишков В.И., Комолова Г.С. Защитное действие продуктов протеолиза альфа-лактальбумина против язвенных повреждений слизистой желудка крыс // Вопросы биологической, медицинской и фармацевтической химии. 2013. № 8. С. 53–57.
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