Stady of Hypoglycemic activity of oxovanadium complexes on the basis of hetarylamides of 4-aryl-2-hydroxy-4-oxo-2-butenoic acid

N.A. Pulina; A.I. Krasnova; T.A. Yushkova; V.V. Yushkov; F.V. Sobin

Stady of Hypoglycemic activity of oxovanadium complexes on the basis of hetarylamides of 4-aryl-2-hydroxy-4-oxo-2-butenoic acid

N.A. Pulina¹, A.I. Krasnova², T.A. Yushkova³, V.V. Yushkov⁴, F.V. Sobin⁵

research article Pages: 26-30

¹ д.фарм.н., профессор, зав. кафедрой фармацевтической технологии, Пермская государственная фармацевтическая академия
² к.фарм.н., ассистент, кафедра фармакологии, Пермская государственная фармацевтическая академия
^3,4 д.м.н., профессор, кафедра фармакологии, Пермская государственная фармацевтическая академия
⁵ к.фарм.н., ст. преподаватель, кафедра фармацевтической технологии, Пермская государственная фармацевтическая академия

Keywords: complex compounds of vanadium (IV)hypoglycemic activity

Abstract

The reaction of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids with vanadyl sulfate gives corresponding bis{3-aryl-1-[2(3)-pyridyl] carboxamido-1,3-propandionato}oxovanadium and bis{3-aryl-1-[2(5-R-1,3,4-thiadiazolyl)]carboxamido-1,3-propandionato}oxovanadium is studied.

Hypoglycemic activity and acute toxicity of complex compounds together with starting ligands are described. The obtained metal complexes are found to belong to danger class 4 and less toxic than metformin. It is revealed that hypoglycemic activity is mostly affected by introduction of 2(3)-pyridyl fragment into oxovanadium complex structure.

How to cite

Пулина Н.А., Краснова А.И., Юшкова Т.А., Юшков В.В., Собин Ф.В. Изучение гипогликемической активности оксованадиевых комплексов на основе гетариламидов 4-арил-2-гидрокси-4-оксо-2-бутеновых кислот // Вопросы биологической, медицинской и фармацевтической химии. 2013. № 4. С. 26–30.

References

Steiner G. Implications of the global diabetic epidemic // Diabetes and Vascular Disease Research. 2006. V. 3. № 1. R. 2-5.
Sakurai H. A new concept: the use of vanadium complexes in the treatment of diabetes mellitus // Chem. Rec. 2002. V. 2. P. 237-248.
Beljaeva N.F., Gorodeckijj V.K., Tochilkin A.I. Vanadijjsoderzhashhie soedinenija - novyjj klass terapevticheskikh sredstv dlja lechenija sakharnogo diabeta // Voprosy medicinskojj khimii. 2000. T. 46. № 4. S. 344-360.
Thompson K.H., McNeill J.H., Orvig C. Vanadium compounds as insulin mimics // Chem. Rev. 1999. V. 99. P. 2561 - 2571.
Pulina N.A., JUshkova T.A., Krasnova A.I., Sobin F.V., JUshkov V.V. Gipoglikemicheskaja aktivnost proizvodnykh aroilpirovinogradnykh kislot // Farmacija. 2009. № 7. S. 37-38.
Pulina N.A., JUshkova T.A., Krasnova A.I., JUshkov V.V. Napravlennyjj poisk gipoglikemicheskikh soedinenijj v rjadu proizvodnykh aroilpirovinogradnykh kislot //Vestnik RUDN. Ser. Medicina. 2010. № 4. S. 423-425.
Kudrin A.N., Ponomareva G.T. Metod G.N. Pershina // Primenenie matematiki v ehksperimentalnojj i klinicheskojj medicine. M.: Medicina. 1967. Gl. 9. S. 209-210.
Rukovodstvo po ehksperimentalnomu (doklinicheskomu) izucheniju novykh farmakologicheskikh veshhestv / pod red. R.U. KHabrieva.M. 2005. 828 s.
Palchikova N.A., Seljatickaja V.G., SHorin JU.P.Kolichestvennaja ocenka chuvstvitelnosti ehksperimentalnykh zhivotnykh k diabetogennomu dejjstviju alloksana // Problemy ehndokrinologii. 1987. № 4. S. 65-68.
Mashkovskijj M.D. Lekarstvennye sredstva. Izd.15-e, pererab., ispr. i dop. M.: Novaja volna. 2005. 1200 s.
JUrasova A.A., Makarova A.S., Skobelev D.O.Vnedrenie v Rossijjskojj Federacii sovremennojj modeli klassifikacii opasnosti khimicheskojj produkcii // Toksikologich. vestnik. 2011. № 1. S. 2-10.

[1] Steiner G. Implications of the global diabetic epidemic // Diabetes and Vascular Disease Research. 2006. V. 3. № 1. R. 2-5.

[2] Sakurai H. A new concept: the use of vanadium complexes in the treatment of diabetes mellitus // Chem. Rec. 2002. V. 2. P. 237-248.

[3] Beljaeva N.F., Gorodeckijj V.K., Tochilkin A.I. Vanadijjsoderzhashhie soedinenija - novyjj klass terapevticheskikh sredstv dlja lechenija sakharnogo diabeta // Voprosy medicinskojj khimii. 2000. T. 46. № 4. S. 344-360.

[4] Thompson K.H., McNeill J.H., Orvig C. Vanadium compounds as insulin mimics // Chem. Rev. 1999. V. 99. P. 2561 - 2571.

[5] Pulina N.A., JUshkova T.A., Krasnova A.I., Sobin F.V., JUshkov V.V. Gipoglikemicheskaja aktivnost proizvodnykh aroilpirovinogradnykh kislot // Farmacija. 2009. № 7. S. 37-38.

[6] Pulina N.A., JUshkova T.A., Krasnova A.I., JUshkov V.V. Napravlennyjj poisk gipoglikemicheskikh soedinenijj v rjadu proizvodnykh aroilpirovinogradnykh kislot //Vestnik RUDN. Ser. Medicina. 2010. № 4. S. 423-425.

[7] Kudrin A.N., Ponomareva G.T. Metod G.N. Pershina // Primenenie matematiki v ehksperimentalnojj i klinicheskojj medicine. M.: Medicina. 1967. Gl. 9. S. 209-210.

[8] Rukovodstvo po ehksperimentalnomu (doklinicheskomu) izucheniju novykh farmakologicheskikh veshhestv / pod red. R.U. KHabrieva.M. 2005. 828 s.

[9] Palchikova N.A., Seljatickaja V.G., SHorin JU.P.Kolichestvennaja ocenka chuvstvitelnosti ehksperimentalnykh zhivotnykh k diabetogennomu dejjstviju alloksana // Problemy ehndokrinologii. 1987. № 4. S. 65-68.

[10] Mashkovskijj M.D. Lekarstvennye sredstva. Izd.15-e, pererab., ispr. i dop. M.: Novaja volna. 2005. 1200 s.

[11] JUrasova A.A., Makarova A.S., Skobelev D.O.Vnedrenie v Rossijjskojj Federacii sovremennojj modeli klassifikacii opasnosti khimicheskojj produkcii // Toksikologich. vestnik. 2011. № 1. S. 2-10.