Preclinical study of safety antimicrobial рhytodrug Sanguiritrin

Preclinical study of antibacterial phytodrug sanguiritrin, isolated from the grass of Macleaya cordata (Willd.) R. Br.) and Macleaya microcarpa (Maxim.) Fedde (Papaveraceae) have been studied. Sanguiritrin, is a mixture of bisulfats two alkaloids sangvinarina and heleritrina. On the parameters of toxicity by a single intraperitoneal and intragastric introduction mice, rats and cavies sanguiritrin belongs to a class of moderately toxic substances. In chronic 90-day experiment on rats case of introduction into stomach sanguiritrin in a dose of 2 mg/kg had expressed toxic effect on hematological, biochemical, functional, pathohistological indicators.

Sanguiritrin doses of 10 and 50 mg/kg (1/50 and 1/10 of LD50) in the application of per` os can have toxic effects on hepatobiliary and the excretory system of rats. Repeated applications sanguiritrin liniment 0.5 % on back skin of rabbits does not cause a damaging effect on the internal organs and systems of the organism, do not irritate the skin at the site of the preparation.

Sanguiritrin has a pronounced local irritant action. The sanguiritrin not identified embryotoxic, teratogenic, allergenic, mutagenic and carcinogenic properties. Phytodrug sanguiritrin as a liniment of 0.5 % is permitted for use in surgical, gynaecological, dental and оtolaryngology practice, the results of which confirmed its low toxicity and good tolerability.