Carcinoid syndrome in neuroendocrine tumors of the organs of abdominal cavity and retroperitoneal space and it association with disease prognosis
- 1 к.м.н., доцент кафедры онкологии, Первый Московский государственный медицинский университет им. М.И. Сеченова
- 2 д.б.н., проф., Российский онкологический научный центр им. Н.Н. Блохина РАМН
- 3 д.м.н., вед. науч. сотрудник, Российский онкологический научный центр им. Н.Н. Блохина РАМН
- 4 д.м.н., вед. научн. сотрудник, отделения хирургической эндокринологии, Московский областной научно-исследовательский институт им. М.Ф. Владимирского
- 5 к.м.н., ст. научн. сотрудник, Российский онкологический научный центр им. Н.Н. Блохина РАМН
- 6 д.м.н., проф., чл.-корр. РАМН, зав. отделением хирургической эндокринологии, Московский областной научно-исследовательский институт им. М.Ф. Владимирского
- 7 академик РАН и РАМН, проф., директор, Российский онкологический научный центр им. Н.Н. Блохина РАМН
Abstract
The results of overall and disease-free survival analysis in 238 patients with neuroendocrine tumors of the organs of abdominal cavity and retroperitoneal space depending on the presence of carcinoid syndrome are represented. The prevalence of carcinoid syndrome comprised 15.6%. carcinoid syndrome did not affect life expectancy and relapse prognosis in patients with neuroendocrine tumors of the organs of abdominal cavity and retroperitoneal space. Only a trend towards earlier relapse was observed in patients with this syndrome. The presence of such clinical symptom as diarrhea was a prognostically unfavorable factor. Time of the development of carcinoid syndrome also had a certain prognostic value in patients with malignant neuroendocrine tumors. Mean adrenalin, noradrenalin and dophamine excretion with daily urine was significantly higher in patients with neuroedocrine tumors of medullary substance of adrenal gland (pheochromocytoma).
How to cite
Поликарпова С.Б., Любимова Н.В., Ожерельев А.С., Бритвин Т.А., Костылева О.И., Калинин А.П., Давыдов М.И. Карциноидный синдром при нейроэндокринных опухолях органов брюшной полости и забрюшинного пространства и его связь с прогнозом болезни // Вопросы биологической, медицинской и фармацевтической химии. 2010. № 11. С. 37–41.
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