Influence of delivery of MMP-1 gene on expression of leading clinical syndromes and effectiveness of therapy for patients with tuberculosis of lungs

Людмила Геннадиевна Тарасова; Елена Николаевна Стрельцова; Халил Мингалиевич Галимзянов; Бэла Исмаиловна Кантемирова

Influence of delivery of MMP-1 gene on expression of leading clinical syndromes and effectiveness of therapy for patients with tuberculosis of lungs

Людмила Геннадиевна Тарасова¹, Елена Николаевна Стрельцова², Халил Мингалиевич Галимзянов³, Бэла Исмаиловна Кантемирова⁴

research article Pages: 52-57

¹ к.м.н., доцент, кафедра фтизиатрии, Астраханский государственный медицинский университет
² д.м.н., профессор, зав. кафедрой фтизиатрии, Астраханский государственный медицинский университет
³ д.м.н., профессор, зав. кафедрой инфекционных болезней, Астраханский государственный медицинский университет
⁴ д.м.н., директор Научно-исследовательского института краевой инфекционной патологии, Астраханский государственный медицинский университет

Keywords: pulmonary tuberculosis matrix metalloprotease-1 polymorphism ММР-1 protracted course pathogenetic therapy

Abstract

The medico-social meaning of tuberculosis dictates the need to search for new genetic predictors that predetermine a protracted and difficult course, one of which can be the deletion of the matrix metalloprotease-1 (MMP-1) 2G / 2G gene, leading to the expression of clinical syndromes and affecting the effectiveness of specific therapy. The scientific research established the relationship between the polymorphism of the MMP-1 gene and the severity of the clinical course of pulmonary tuberculosis. MMP-1 was determined in 73 patients with pulmonary tuberculosis: group 1 with MMP-1 G1 / G1 genotype - 15 people (20,5 %), 2nd group with MMP-1 G2/G1 genotype - 27 people (50,7 %) and the third group - the genotype MMP-1 G2/G2 - 21 people (28,8 %). The patients of the 3rd group had significantly longer periods of symptoms, intoxication and bronchopulmonary disorders, delayed resolution of pulmonary tissue infiltration and closure of the decay cavities than in patients of the 1st and 2nd groups (p < 0,05). The detection of a polymorphic variant of MMP-1 2G/2G in patients with pulmonary tuberculosis can be a prognostic point of protracted course and a rationale for the appointment of pathogenetic therapy.

How to cite

Тарасова Л.Г., Стрельцова Е.Н., Галимзянов Х.М., Кантемирова Б.И. Влияние делеции гена ММР-1 на экспрессию ведущих клинических синдромов и эффективность терапии у больных туберкулезом легких // Технологии живых систем. 2017. № 3. С. 52–57.

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[1] Gaparkhoeva Z.M., Seliverstova E.N., Strojjkova T.R., Bashkina O.A., Demidova L.V. Sovremennye predstavlenija o roli geneticheskikh prediktorov pri bronkhialnojj astme u detejj / Astrakhanskijj medicinskijj zhurnal. 2015. T. 10. № 1. S. 6-11.

[2] Apt A.S. Geneticheskie aspekty vyjavlenija grupp riska po tuberkulezu // Problemy tuberkuleza i boleznejj legkikh. 2001. T. 78. № 7. C. 65-68.

[3] Erokhin V.V. Nauchnye issledovanija vo ftiziatrii: dostizhenija i perspektivy // Tuberkulez i bolezni legkikh. 2013. T. 90. № 5. S. 16-23.

[4] Gergert V.JA., Pospelov A.L., Stavickaja N.V., Kordicheva S.JU., Sorokonovickaja A.N., Pospelov L.E. Sravnenie raspredelenija genov lokusa HLA-DRB1 u zdorovykh i bolnykh tuberkulezom detejj i podrostkov v razlichnykh populjacijakh // Tuberkulez i bolezni legkikh. 2010. T. 87. № 9. C. 29-32.

[5] Tarasova L.G., Strelcova E.N., Kantemirova B.I., Galimzjanov KH.M., Kasimova N.B. Citokinovyjj profil u bolnykh tuberkulezom legkikh // Astrakhanskijj medicinskijj zhurnal. 2016. T. 11. № 2. S. 84-92.

[6] Salgame P. MMPs in tuberculosis: granuloma creators and tissue destroyers // J. Clin. Invest. 2011. May. V. 121(5).P. 1686-1688.

[7] Ganachari M., Ruiz-Morales J.A., Gomez de la Torre Pretell J.C., Dinh J., Granados J., Flores-Villanueva P.O. Joint effect of MCP-1 genotype GG and MMP-1 genotype 2G/2G increases the likelihood of developing pulmonarytuberculosis in BCG-vaccinated individuals // PLoS One. 2010. Jan. V. 25. № 5(1). P. e8881.

[8] Ganachari M., Guio H., Zhao N., Flores-Villanueva P.O. Host gene-encoded severe lung TB: from genes to the potential pathways // Genes Immun. 2012. Dec. V. 13(8). P. 605-620.

[9] Wang C.H., Lin H.C., Lin S.M., Huang C.D., Liu C.Y., Huang K.H. et. al. MMP-1(-1607G) polymorphism as a risk factor for fibrosis after pulmonary tuberculosis in Taiwan // Int. J. Tuberc. Lung Dis. 2010. V. 14(5). P. 627-634.

[10] CHabanova O.N., Strelcova E.N., Serdjukov A.G. EHpidemiologicheskie i mediko-socialnye problemy tuberkuleza. Astrakhan: Astrakhanskaja gos. med. akademija. 2010. 135 s.

[11] CHabanova O.N., Strelcova E.N. Innovacionnye metody obuchenija vo ftiziatrii / Innovacionnye podkhody v sisteme nepreryvnogo medicinskogo obrazovanija ordinatorov. Astrakhan: Astrakhanskijj gosudarstvennyjj medicinskijj universitet. 2016. S. 108-111.

[12] Amlaev K.R., Zafirova V.B., Baronova O.D. Rezultaty izuchenija nekotorykh aspektov kachestva zhizni ftiziatricheskikh pacientov / Astrakhanskijj medicinskijj zhurnal. 2016. T. 11. № 3. S. 53-57.