The role of vitamin d in the immune response in pregnant women with miscarriage of infectious genesis

Татьяна Николаевна Савченко; Лариса Александровна Щеплягина; Юлия Эдуардовна Доброхотова; Татьяна Алексеевна Осипова; Ирина Анатольевна Дергачева; Мадина Ильясовна Агаева

The role of vitamin d in the immune response in pregnant women with miscarriage of infectious genesis

Татьяна Николаевна Савченко¹, Лариса Александровна Щеплягина², Юлия Эдуардовна Доброхотова³, Татьяна Алексеевна Осипова⁴, Ирина Анатольевна Дергачева⁵, Мадина Ильясовна Агаева⁶

research article Pages: 68-73

¹ д.м.н., профессор, кафедра акушерства и гинекологии, лечебный факультет, ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава России (Москва)
² д.м.н., профессор, кафедра педиатрии, ФУВ МОНИКИ; зав. лабораторией экологии и профилактической педиатрии, ФГУ ФНКЦ детской гематологии, онкологии и иммунологии Минздравсоцразвития России (Москва)
³ д.м.н., профессор, зав. кафедрой акушерства и гинекологии, лечебный факультет, ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава России (Москва)
⁴ зав. лабораторией, ООО «ЭФиС» (Москва)
^5,6 аспирант, кафедра акушерства и гинекологии, лечебный факультет, ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава России (Москва)

Keywords: miscarriage vitamin D immunity

Abstract

Over the past decades have seen the role of vitamin D deficiency in the development and persistence of infectious agents, and its impact on the various parts of the immune response.

The objective. To analyze the security of vitamin D women with physiological course of gestation and with miscarriage of infectious genesis, to determine the link between vitamin D levels and the level of cytokines in the blood of pregnant women.

Materials and methods. The study involved 50 pregnant women in the winter-spring period. Of these, 25 women with normal pregnancy, 15 women with threatened miscarriage and 10 women to terminate a pregnancy. All pregnant were diagnosed of urogenital infection, immunity indices with measurement of cytokines in the blood serum. The concentration of 25 (OH) D\'3 in the blood plasma was determined for all pregnant women.

Results and discussion. According to the results of the study found that the value of vitamin D levels below 20 ng / ml often accompanied by miscarriage. Correlation analysis confirmed the relationship between cytokine production and the level of vitamin D in the blood of pregnant women.

Conclusion. Normalization of vitamin D levels in the blood may help prevent miscarriage.

How to cite

Савченко Т.Н., Щеплягина Л.А., Доброхотова Ю.Э., Осипова Т.А., Дергачева И.А., Агаева М.И. Роль витамина D в иммунном ответе у беременных с невынашиванием инфекционного генеза // Технологии живых систем. 2016. № 1. С. 68–73.

References

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[1] Makarov O.V., Kovalchuk L.V., Gankovskaja L.V. i dr. Nevynashivanie beremennosti, infekcija, vrozhdennyjj immunitet. M.: Geotarmedia. 2007. S. 100-105.

[2] Goncalves L.F., Chaiworapongsa T., Romero R. Intrauterine infection and prematurity // Ment. Retard. Dev. Disabil. Res. Rev. 2002. V. 8. P. 3-13.

[3] Lachapelle M.H., Miron P., et al. Endometrial T, B, and NK cells in patients with recurrent spontaneous abortions. Altered profile and pregnancy outcome // J. Immunol. 1996. V. 156. № 10. R. 4027-4034.

[4] Savchenko T.N. Mikrobiologicheskie aspekty i faktory protivomikrobnojj zashhity v geneze nevynashivanija beremennosti v I trimestre: Avtoref. diss. na soiskanie uch. st. dokt. med. nauk. M. 2008.

[5] Bikle D. Nonclassic action of vitamin D // J. Clin. Endocrinol. Metab. 2009. V. 94. R. 26e34

[6] Arnson Y., Amital H., Shoenfeld Y. Vitamin D and autoimmunity // Ann. Rheum. Dis. Sep. 2007. V. 66. № 9. R. 1137-1142.

[7] Abaturov A.E. Vitamin-D-zavisimaja produkcija antimikrobnykh peptidov // Zdorove rebenka. 2012. № 1(36). Razdel: spravochnik specialista.

[8] Tian-Tian Wang, Frederick P. Nestel, Véronique Bourdeau, et al. Cutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression // The journal of Immunology. 2004. V. 173. № 5. R. 2909-2912.

[9] Gerald Litwack: Vitamins and Immune System. N.V. Academic Press. 2011. 476 p.

[10] Talat N., Perry S., Parsonnet J., Dawood G., Hussain R.Vitamin D Deficiency and Tuberculosis Progression // EmergInfect. Dis. May 2010. V. 16. № 5. R. 853-855.

[11] Bodnar L.M., Krohn M.A., Simhan H.N.Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy // J. Nutr. 2009. V.139. R.1157e61

[12] Jahnsen J., Falch J.A., Mowinckel P., Aadland E. Vitamin D status, parathyroid hormone and bone mineral density in patients with inflammatory bowel disease // Scand. J. Gastroenterol. 2002. V. 37. R.192-199.

[13] Choi B., Lee E.S., Sohn S. Vitamin D3 ameliorates herpes simplex virus-induced Behçet\'s disease-like inflammation in a mouse model through down-regulation of Toll-like receptors // Clin. Exp. Rheumatol. 2011. V. 29. № 4. Suppl. 67. P. 13-19.

[14] Klinicheskie rekomendacii. Deficit vitamina D: diagnostika, lechenie i profilaktika / pod red. prof., akad. RAN I.I. Dedova, prof., akad. RAN G.A. Melnichenko. M. 2014. 77 s.

[15] BoneClub / HochbergZ. (ed.). VitaminDandRickets. Enocr. Dev. Basel. Karger. 2003. V. 6. R. 259-281.

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