Treatment of metabolic syndrome in persons of extreme professions in rela-tion to the problems of aerospace medicine

Анна Георгиевна Гончарова; Юрий Иванович Воронков; Ирина Евгеньевна Зыкова; Леонид Хрисанфович Брагин; Гелена Александровна Тихонова; Дмитрий Леонидович Брагин

Treatment of metabolic syndrome in persons of extreme professions in rela-tion to the problems of aerospace medicine

Анна Георгиевна Гончарова¹, Юрий Иванович Воронков², Ирина Евгеньевна Зыкова³, Леонид Хрисанфович Брагин⁴, Гелена Александровна Тихонова⁵, Дмитрий Леонидович Брагин⁶

research article Pages: 72-78

^1,4 д.м.н., ФГБУН Государственный научный центр РФ - Институт медико-биологических проблем РАН
² д.м.н., профессор, ФГБУН Государственный научный центр РФ - Институт медико-биологических проблем РАН
³ д.м.н., директор АНО Центр медико-экологических проблем РАЕН
⁵ к.м.н., ФГБУН Государственный научный центр РФ - Институт медико-биологических проблем РАН
⁶ науч. сотрудник, ФГБУН Государственный научный центр РФ - Институт медико-биологических проблем РАН

Keywords: metabolic syndrome immunoreactive insulin remodeling combined treatment of extreme professions persons

Abstract

Simulation of the main risk factors in IBMP experiments as well as the real manned space flight results indicate the possibility of development of insulin resistance and associated conditions classified as metabolic syndrome. A total of 58 men aged 35 - 5 with metabolic syndrome and with 10 to 20 years work experience in \"extreme conditions\" were studied. Treatment with telmisartan, losartan and enalapril in combination with bisoprolol, small doses of spironolactone and diuretics allowed to achieve full control of BP and HR without changing conditions. Cardioprotective, angioprotective and renoprotective effects of such combined treatment were marked. This allowed us to consider the remodeling processes of the cardiovascular and endocrine systems as adaptation to changed life conditions as well as to combined treatment during continuing high-intensity work and emotional stress.

How to cite

Гончарова А.Г., Воронков Ю.И., Зыкова И.Е., Брагин Л.Х., Тихонова Г.А., Брагин Д.Л. Особенности терапии метаболического синдрома у лиц экстремальных профессий применительно к проблемам авиакосмической медицины // Технологии живых систем. 2015. № 3. С. 72–78.

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[1] Algoritmy specializirovannojj medicinskojj pomoshhi bolnym sakharnym diabetom / pod red. I.I. Dedova, M.V. SHestakovojj. Izd. 6-e. M., 2013.

[2] Volkova A.E., Malygina O.F. Nekotorye problemy profilaktiki i lechenija sakharnogo diabeta tipa 2 // Cons.Med. 2014. V. 5 (16). P. 105-112.

[3] Drapkina O.M., Popova I.R. Rol ozhirenija v razvitii arterialnojj gipertenzii i nealkogolnojj zhirovojj bolezni pecheni // Consilium medicum 2012. T.12. № 14. S.72-75.

[4] Korneeva O.N., Drapkina O.M. Nealkogolnaja zhirovaja bolezn pecheni u pacientov s metabolicheskim sindromom // Rossijjskijj ZHurnal gastroehnterologii, gepatologii, koloproktologii. (Pril. 29). 2007. T17 (1). S. 65.

[5] Oganov R.G., Aleksandrov A.A. Giperinsulinemija i arterialnaja gipertenzija: vozvrashhajas k vyvodam // Russkijj medicinskijj zhurnal. 2001. T. 7 (30). S. 6-10.

[6] Podachnina S.V. Samokontrol kak metod lechenija sakharnogo diabeta: Spravochnik poliklinicheskogo vracha. M. 2014.6. S.21-23.

[7] Titov V.N.Filogeneticheskaja teorija patologii. Obshhnost stanovlenija v filogeneze patogeneza ehssencialnojj arterialnojj gipertonii i sindroma rezistentnosti k insulinu // Sistemnye gipertenzii. 2014. T. 11. № 3. S. 53-60.

[8] SHestakova M.V., Zilov A.V. Vybor optimalnojj sakharosnizhajushhejj terapii u pacientov s sakharnym diabetom tipa 2 v debjute zabolevanija // Consilium medicum 2010. T. 12. № 12. S. 5-10.

[9] Li GW, Hu ZX et al.Effect of diet and exercise in prevention NIDDM in people with impaired glucose tolerance: the DaQing IGT and diabetes study // Diabetes Care 2007. V. 30. R. 744-54.

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