System of insulin-like growth factors in patients with cin and invasive cervical cancer
- 1 к.м.н., ст. науч. сотрудник, поликлиника ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН (Москва)
- 2 врач-гинеколог, ФГБУ «Научный центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова» МЗ РФ (Москва)
- 3 д.б.н., профессор, лаборатория клинической биохимии, ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН
- 4 к.м.н., вед. науч. сотрудник, отдел патологической анатомии опухолей человека, ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН
- 5 вед. инженер, лаборатория клинической биохимии, ФГБУ «Российский онкологический научный центр им. Н.Н.Блохина» РАМН
Abstract
Cell proliferation and apoptosis are especially important for the formation of CIN and invasive cervical cancer. Insulin-like growth factors (IGF) 1 and 2, and several IGF-binding proteins (IGFBP) have been shown to play an important role in regulation of cell proliferation, differentiation and apoptosis. 64 patients with cervical neoplasia (22 CIN1-2, 7 microinvasive and 35 invasive cancer) and 16 women with no signs of cervical neoplasia were included in the study. The chosen stages present the important hallmarks of cancerogenesis: induction (CIN1-2), rupture of basal membrane (microinvasive cancer) and evident invasion (1B1 invasive cancer). Serum IGF-1, IGF-2, IGFPB-1, IGFPB-3 levels were measured by enzyme-linked immunoassays before treatment and IGFBP-1/IGFPB-3 rate was also assessed. In invasive cancer significant IGF-1, IGF-2, IGFPB-3 down-regulation as well as increase in IGFPB-1 level and IGFPB-1/IGFPB-3 rate was revealed. The only significant changes in microinvasive cancer were IGF-1 decrease and IGFPB-1 increase. Similar although not significant changes were seen in CIN1-2 patients thus confirming these proteins to be involved in cervical cancerogenesis. IGF family proteins might be perspective progression and «latent» invasion markers for patients with high-grade epithelial lesions. Lower IGF-1, IGF-2 and IGFPB-3 values as well as increased IGFPB-1 may reveal invasive cervical lesions. There is a need for further investigations to assess the critical IGF-1, IGF-2, IGFBP-3, IGFPB-1, IGFBP-1/IGFBP-3 endpoints associated with invasion.
How to cite
Короленкова Л.И., Кушлинский Д.Н., Герштейн Е.С., Ермилова В.Д., Дворова Е.К. Система инсулиноподобных факторов роста у больных цервикальной интраэпителиальной CIN, рак шейки матки, инсулиноподобные факторы роста, прогноз, инвазиянеоплазией и инвазивным раком шейки матки // Технологии живых систем. 2013. № 4. С. 47–52.
References
- Korolenkova L.I. Diagnostika neizlechennosti i recidivov preinvazivnogo i mikroinvazivnogo raka shejjki matki s pomoshhju VPCH-testirovanija metodom gibridnogo zakhvata // Voprosy biologicheskojj, medicinskojj i farmacevticheskojj khimii. 2011. № 12. S. 23 - 27.
- McCredie M.R., Sharples K.J., Paul C. et al. Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study // Lancet Oncol. 2008. V. 9. P. 425 - 434.
- Zur Hausen H. Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis // J. Natl. Cancer Inst. 2000. V. 92. P. 690 - 698.
- Prétet J.L., Jacquard A.C., Carcopino X., Monnier-Benoit S. Human papillomavirus genotype distribution in high grade cervical lesions (CIN 2/3) in France: EDITH study // Int. J. Cancer.2008. V. 122. № 2. P. 424 - 427.
- Bosch F.X. Global Burden of HPV Associated Diseases // Workshop book, 25th International Conference Clinical and Educational. Workshop. 2009. P. 44 - 83.
- Kovanda A., Juvan U., Sterbenc A. et al.Pre-vaccination distribution of human papillomavirus (HPV) genotypes in women with cervical intraepithelial neoplasia grade 3 (CIN 3) lesions in Slovenia //Acta Dermatovenerol. Alp. PanonicaAdriat. 2009. V. 18. № 2. P. 47 - 52.
- Kushlinskijj N.E., Timofeev JU.S. Sistema insulinopodobnykh faktorov rosta // Voprosy biologicheskojj, medicinskojj i farmacevticheskojj khimii. 2011. № 12. S. 3 - 22.
- Lee S.W., Lee S.Y., Lee S.R., Ju W., Kim S.C.Plasma levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in women with cervical neoplasia // J. Gynecol. Oncol. 2010. V. 21. № 3. P. 174 - 180.
- Pollak M.Insulin-like growth factor physiology and cancer risk // Eur. J. Cancer.2000. V. 36. P. 1224 - 1228.
- Hirano S., Ito N., Takahashi S., Tamaya T.Clinical implications of insulin-like growth factors through the presence of their binding proteins and receptors expressed in gynecological cancers // Eur. J. Gynaecol. Oncol. 2004. V. 25. № 2. P. 187 - 191.
- Wu X., Tortolero-Luna G., Zhao H., Phatak D., Spitz M.R., Follen M. Serum levels of insulin-like growth factor I and risk of squamous intraepithelial lesions of the cervix // Clin. Cancer Res. 2003. V. 9. P. 3356 - 3361.
- Serrano M.L., Romero A., Cendales R., Sanchez-Gomez M., Bravo M.M. Serum levels of insulin-like growth factor-I and -II and insulin-like growth factor binding protein 3 in women with squamous intraepithelial lesions and cervical cancer // Biomedica. 2006. V. 26. P. 258 - 268.