Immunohistochemical study of the caveolin-1 expression in esophageal squamous cell carcinoma
Abstract
The aim of our study was to analyze the clinical significance of the Cav-1 immunohistochemical expression in 52 esophageal squamous cell carcinomas (ESCC) and 20 adenocarcinomas of the esophagus. Increased Cav-1 immunoxpression appears to play an important role as a marker of prognosis and aggressive biological behaviour in ESCC, but not in adenocarcinoma of the esophagus. The high level of Cav-1 expression was correlated with tumor histological differentiation (р = 0,020), distant lymph node metastasis (р = 0,027) and shorter overall survival (р = 0,039) of ESCC patients.
Our results indicate that the increased Cav-1 expression in ESCC is associated with tumor progression and may be useful in personalized prognosis of disease progression and future therapeutic approaches for ESCC patients.
How to cite
Делекторская В.В., Чемерис Г.Ю., Кононец П.В., Бондаренко Ю.В., Зборовская И.Б. Иммуногистохимическое исследование экспрессии кавеолина-1 при плоскоклеточном раке пищевода // Технологии живых систем. 2012. № 3. С. 8–13.
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