SEASONAL VARIATION IN LIPID LEVELS IN THE HEALTHY WOMEN

The article is devoted to study seasonal change blood lipid levels in the healthy women. The 195 healthy women volunteers aged 20 to 30 years in mid-follicular and mid-luteal phase of the men-strual cycle were examined four times of the year: in winter (January, February), spring (April, May), summer (July, August) and autumn (October, November). Is established, that in the healthy women the level total cholesterol, LDL cholesterol, triglyce-rides, free fatty acids and apolipoprotein В in the blood serum significant higher in the winter, HDL cholesterol and C-reactive protein - spring, apolipoprotein А-1  summer, and lipoproteins of very low density cholesterol  autumn (p < 0,05). The average annual meaning The average annual meaning of the concentration total cholesterol, LDL cholesterol, triglycerides, free fatty acids, apolipoprotein В and C-reactive protein significant higher in the mid-follicular phase, lipoproteins of very low density cholesterol and apolipoprotein А-1 - in the mid-luteal (p < 0,05). Is revealed, that the maximal meanings of the atherogenic index and ratio ApoВ/ApoА-I were observed in the winter, and minimal  summer (р < 0,05). The average annual meaning of the atherogenic index significant higher in the mid-luteal phase, and ApoВ/АpoА-I in mid-follicular (p < 0,05). Thus the statistically significant seasonal variation of blood lipid levels in healthy women in different phase of the menstrual cycle are revealed.