The universal recipient - the first step on a way to the universal donor

V.I. Shumakov; L.K. Ernst; A.A. Lubyako

The universal recipient - the first step on a way to the universal donor

V.I. Shumakov¹, L.K. Ernst², A.A. Lubyako³

research article Pages: 45-47

¹ Dr. Sc. (Med.), Professor, Academician of RAS and RAMS
² Dr. Sc. (Biol.), Professor, Academician of RAAS
³ Dr. Sc. (Biol.), Professor, Head of Department, Research Center of Balneology and Rehabilitation of Federal Medical-Biological Agency (Sochi)

Keywords: transgenic technologies transplantation universal donor

Abstract

At a certain stage of ontogenesis in a genome of a pig the genetic information (transgenic) responsible for a tissues compatibility to a genome of Homo sapiens was placed. In 1 year and 3 months at animals blood samples for research on AB 0 compatibility with standard serums of the person of 0 (I), A (II), B (III) and AB (IV) groups were taken. Research showed that in blood of a skilled animal isn\'t revealed antibodies to AB anti-genes of Homo sapiens. The conclusion is drawn that the animal received as a result of gene re-construction can be qualified as the universal recipient of blood. It is the first step on a way to creation of the universal donor for the Homo sapiens.

How to cite

Шумаков В.И., Эрнст Л.К., Лубяко А.А. Универсальный реципиент - первый шаг на пути к универсальному донору // Наукоемкие технологии. 2015. № 5. С. 45–47.

References

Molekuljarnyjj polimorfizm cheloveka / Pod red. S.D. Varfolomeeva. M.: RUDN. 2007. T. I−II. 810 s.
Lubjako A.A. Gomeostaz. Mekhanizmy formirovanija, adaptacii, edinoobraznogo ustrojjstva. Sochi. 2010. 523 s.
Dosse ZH., Rapaport F.T. Sistema tkanevojj sovmestimosti u cheloveka Hu-1 / V kn.: Peresadka organov i tkanejj u cheloveka. M.: Medicina. 1973. S. 313−327.
EHnciklopedicheskijj slovar medicinskikh terminov / Pod red. B.V. Petrovskogo. M.: Sovetskaja ehnciklopedija. 1984. T. III. S. 252.
Transplantologija. Rukovodstvo /Pod red. V.I. SHumakova. M.: Medicina. 1995. 391 s.
EHrnst L.K., SHatajjlo V.I. Vlijanie integracii chuzherodnykh genov na fenotip svinejj. M. 2001. 160 s.
Burnet F.M. Clonal selection theory of acquired immunology. London:CambridgeUniversityPress. 1959.
Lubyako A.A., Kirpatovsky V.I., Kurapeev I.S., Novikov V.K., Slobin V.N., Tyunina G.K., Gaidova O.S., Pimenov A.V., Gnevashev A.S.Organotherapy. Experience on rehabilitation of organs and tissues and their functions and some recommendations to doctors, medical students and scientific employees / Under edition of Prof. I.D. Kirpatovsky. M. 2003. 49 p.
Mac-Laren A. (Mak-Laren EH.) KHimery mlekopitajushhikh. M. 1979.
Mitchison N.A.Immunology. 1965. 129 p.
Nossal G.J.V. Immunologicheskaja tolerantnost / V kn: Peresadka organov i tkanejj u cheloveka. M.: Medicina. 1973. S. 478−493.
Palmiter R.D., Brinster R.L., Hammer R.E.et al. Dramaticgrowthofmicethatdevelopfromeggsmicroinjectedwithmetallothionein-growthhormonefusiongenes // Nature. 1982. V. 306. P. 611−615.
Ward K.A., Nancarrow C.D. The genetic engineering of production traits domestic animals // Experimenta. 1991. V. 47. P. 913−922.

[1] Molekuljarnyjj polimorfizm cheloveka / Pod red. S.D. Varfolomeeva. M.: RUDN. 2007. T. I−II. 810 s.

[2] Lubjako A.A. Gomeostaz. Mekhanizmy formirovanija, adaptacii, edinoobraznogo ustrojjstva. Sochi. 2010. 523 s.

[3] Dosse ZH., Rapaport F.T. Sistema tkanevojj sovmestimosti u cheloveka Hu-1 / V kn.: Peresadka organov i tkanejj u cheloveka. M.: Medicina. 1973. S. 313−327.

[4] EHnciklopedicheskijj slovar medicinskikh terminov / Pod red. B.V. Petrovskogo. M.: Sovetskaja ehnciklopedija. 1984. T. III. S. 252.

[5] Transplantologija. Rukovodstvo /Pod red. V.I. SHumakova. M.: Medicina. 1995. 391 s.

[6] EHrnst L.K., SHatajjlo V.I. Vlijanie integracii chuzherodnykh genov na fenotip svinejj. M. 2001. 160 s.

[7] Burnet F.M. Clonal selection theory of acquired immunology. London:CambridgeUniversityPress. 1959.

[8] Lubyako A.A., Kirpatovsky V.I., Kurapeev I.S., Novikov V.K., Slobin V.N., Tyunina G.K., Gaidova O.S., Pimenov A.V., Gnevashev A.S.Organotherapy. Experience on rehabilitation of organs and tissues and their functions and some recommendations to doctors, medical students and scientific employees / Under edition of Prof. I.D. Kirpatovsky. M. 2003. 49 p.

[9] Mac-Laren A. (Mak-Laren EH.) KHimery mlekopitajushhikh. M. 1979.

[10] Mitchison N.A.Immunology. 1965. 129 p.

[11] Nossal G.J.V. Immunologicheskaja tolerantnost / V kn: Peresadka organov i tkanejj u cheloveka. M.: Medicina. 1973. S. 478−493.

[12] Palmiter R.D., Brinster R.L., Hammer R.E.et al. Dramaticgrowthofmicethatdevelopfromeggsmicroinjectedwithmetallothionein-growthhormonefusiongenes // Nature. 1982. V. 306. P. 611−615.

[13] Ward K.A., Nancarrow C.D. The genetic engineering of production traits domestic animals // Experimenta. 1991. V. 47. P. 913−922.

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