Cytogenetic investigation of lymphocytes of peripherial blood of workers of metal processing
- 1 к.б.н., профессор, зав. кафедрой клинической лабораторной диагностики, Факультет повышения квалификации медицинских работников, Российский университет дружбы народов. (Москва)
- 2 д.м.н., профессор, зав. кафедрой клинической физиологии и нелекарственных методов терапии, Факультет повышения квалификации медицинских работников, Российский университет дружбы народов (Москва). Д. С. Стаситите-Бунявичене - к.м.н., преподаватель кафедры, кафедра клинической физиологии и нелекарственных методов терапии, Факультет повышения квалификации медицинских работников, Российский университет дружбы народов (Москва)
Abstract
In literature issues information about mutagenic and genotoxic activity of chemical substances used in technology of metal processing is announced. Present study aimed to investigate cytogenetic indices of lymphocytes of peripherial blood of people working under impact of harmful factors of metal processing for a long-term period. 31 workers from 2 shops from enterprise of heavy industry aged 35-54 years took part in the investigation. Control group was formed of 90 persons of the same age without contact with genotoxic industrial agents. Chromosoma were studied, detecting aberrant metaphases and chromosomal aberrations in lymphocytes of peripherial blood. Chromosomal aberrations in lymphocytes of workers from the 1-st shop were found more often, by 31.8% if comparing with the same ones of control group (p < 0.05). During cytogenetic investigation, alterations of chromosomas in lymphocytes of peripherial blood of people working under impact of harmful chemical agents of metal processing were detected. Genotoxicity of industrial agents manifested as chromatidial and chromosomal aberrations and correlated to level of industrial contamination. No significant differences of injuries according to sex and smoking were found.
How to cite
Омельчук Н.Н., Татаринцева Р.Я. Цитогенетическое исследование лимфоцитов периферической крови рабочих, занятых в процессах металлообработки // Нейрокомпьютеры: разработка, применение. 2014. № 8. С. 47–50.
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