The impact of single-walled carbon nanotubes on the synthesis of cytokines and the c-fos expression in the rat brain
- 1 Dr.Sc. (Biol.), Head of the Laboratory of Tissue Cultures, D.I. Ivanovsky Institute of Virology (Moscow)
- 2 Research Scientist, Laboratory of Tissue Cultures, D.I. Ivanovsky Institute of Virology, Moscow
- 3 Dr.Sc. (Biol.), Principal Research Scientist, Laboratory of Functional Neurocytology, Institute of Higher Nervous Activity and Neurophysiology of RAS (Moscow)
- 4 Ph.D. (Biol.), Research Scientist, Laboratory of Functional Neurocytology, Institute of Higher Nervous Activity and Neurophysiology of RAS (Moscow)
- 5 Assistant, Laboratory of Functional Neurocytology, Institute of Higher Nervous Activity and Neurophysiology of RAS (Moscow)
- 6 Research Scientist, Laboratory of Tissue Cultures, D.I. Ivanovsky Institute of Virology (Moscow)
- 7 Ph.D. (Biol.), Leading Research Scientist, Laboratory of Tissue Cultures, D.I. Ivanovsky Institute of Virology (Moscow)
Keywords:
neurosciencesingle-walled carbon nanotubes (SWCN)intranasal introductionrat brainimmunological analysiscytokinesimmunohistochemical analysisc-fos expression
Abstract
It is shown that in 24 hours after intranasal introduction of single-walled carbon nanotubes (SWCN) to rats, according to immunological analysis of some cytokines expression, Th1-type of immune response activated in posterior part and Th2-type activated in anterior part of the brain. In the same time, according to immunohistochemical study, introduction of SWCN didn't influence on c-fos expression in all studied brain structures. That is, the activity of a brain didn't change.
How to cite
Мезенцева М.В., Руссу Л.И., Лосева Е.В., Логинова Н.А., Панов Н.В., Щетвин М.Н., Суетина И.А. Воздействие однослойных углеродных нанотрубок на синтез цитокинов и экспрессию c-fos в головном мозге крыс // Нейрокомпьютеры: разработка, применение. 2014. № 4. С. 38–39.