A.E. Bazhenov1, M.D. Berstneva2, P.A. Prodius3
1–3 Institute of Biology and Biomedicine, National Research Nizhny Novgorod State University named after N.I. Lobachevsky (Nizhny Novgorod, Russia)
3 Privolzhsky Research Medical University PIMU (Nizhny Novgorod, Russia)
1 alexeyyes@yandex.ru, 2 mashaberstneva@mail.ru, 3 prodiusunn@yandex.ru
Working memory is one of the key functions for mental activity. In this work, behavioral and hemodynamic parameters during mnestic activity were studied. N-back tests for working memory were performed with simultaneous recording of the rheoencephalogram (REG) in the basins of the left and right internal carotid and vertebral arteries. The dynamics of REG showed a decrease in blood filling, an increase in vascular tone and difficulty in venous outflow during mnestic activity. Short-term adaptation of cerebral circulation during mnestic activity was accompanied by changes in arterial inflow, venous outflow, as well as the tone of distribution vessels and resistance vessels in the frontal-parietal regions. Optimal and non-optimal typological characteristics of cerebral circulation and features of regulation of cerebral vascular tone during mnestic activity are discussed.
Bazhenov A.E., Berstneva M.D., Prodius P.A. Typological features of cerebral circulation in individuals with different levels of mnestic activity. Technologies of Living Systems. 2026. V. 23. № 1. Р. 48-57. DOI: https://doi.org/10.18127/j20700997-202601-05 (In Russian).
- Baddeley A.D. The episodic buffer: a new component of working memory? Trends in Cognitive Sciences. 2000. V. 4. № 11. P. 417–423. DOI:10.1016/s1364-6613(00)01538-2
- Goldman-Rakic P.S. Circuitry of primate prefrontal cortex and regulation of behavior by representation memory. Handbook of physiology. The nervous system. Higher functions of the brain. Bethesda, MD: American Physiology Society. 1987. V. 5. P. 373–417.
- Kirchner W.K. Age differences in short-term retention of rapidly changing information. Journal of Experimental Psychology.1958. V. 55. №4. P. 352–358.
- Smith E.E., Jonides J. Working memory: A view from neuroimaging. Cognitive Psychology. 1997. V. 33. № 1. P. 5–42.
- Meidenbauer K.L., Choe K.W., Cardenas-Iniguez C. et al. Load-dependent relationships between frontal fNIRS activity and performance: A data-driven PLS approach. NeuroImage. 2021. V. 230. P. 117795. DOI: 10.1016/j.neuroimage.2021.117795
- Zou Q., Gu H., Wang D.J. et al. Quantification of load dependent brain activity in parametric N-back working memory tasks using pseudo-continuous arterial spin labeling (pCASL) perfusion imaging. Journal of Cognitive Science 2011. V. 12. № 2. P. 127–210.
- Curtis C.E., D’Esposito M. Persistent activity in the prefrontal cortex during working memory. Trends Cognitive Sciences. 2003. V. 7. № 9. P. 415–423. DOI: 10.1016/s1364- 6613(03)00197-9
- Zherko O.M. Fizicheskie osnovy ul'trazvukovoj diagnostiki. Minsk: BelMAPO. 2023. 59 s. (in Russian).
- Klingelhofer J., Matzander G., Sander D. et al. Assessment of functional hemispheric asymmetry by bilateral simultaneous cerebral blood flow velocity monitoring. Journal of Cerebral Blood Flow & Metabolism. 1997. V. 17. № 5. P. 577–585.
- Stroobant N., Vingerhoets G. Transcranial Doppler ultrasonography monitoring of cerebral hemodynamics during performance of cognitive tasks: A review. Neuropsychology Review. 2000. V. 10. № 4. P. 213–231.
- Mikadze Yu.V., Bogdanova M.D., Lysenko E.S i dr. Ocenka lateralizacii cerebral'noj gemodinamiki pri vypolnenii verbal'nyh mnesticheskih zadanij metodom funkcional'noj transkranial'noj dopplerografii. Eksperimental'naya psihologiya. 2015. T. 8. № 3. S. 62–73. (in Russian).
- Cupini L.M., Matteis M., Troisi E. et al. Bilateral simultaneous transcranial Doppler monitoring of flow velocity changes during visuospatial and verbal working memory tasks. Brain. 1996. V. 8. № 3. P. 1249–1253.
- Kompleks reograficheskij «Reo-Spektr» Metodicheskie ukazaniya. Ivanovo: Nejrosoft. 2008. 142 s. (in Russian).
- Reo-Spektr.NET. Rukovodstvo pol'zovatelya. Ivanovo: Nejrosoft. 2016. 52 s. (in Russian).
- Yarullin H.H. Klinicheskaya reoencefalografiya. M.: Medicina, 1983. 270 s. (in Russian).
- Peirce J.W. Generating stimuli for neuroscience using PsychoPy. Frontiers in Neuroinformatics. 2009. V. 2. № 10. P. 1–8.
- Yeung M.K., Han Y.M.Y. Changes in task performance and frontal cortex activation within and over sessions during the n‑back task. Scientific Reports. 2023. V. 13. P. 3363. DOI: 10.1038/s41598-023-30552-9
- Rypma B., Berger J.S., D’esposito M. The influence of working-memory demand and subject performance on prefrontal cortical activity. Journal of cognitive neuroscience. 2002. V. 14. № 5. P. 721–731. DOI:10.1162/08989290260138627
- Prodius P.A. Nejrofiziologicheskie markery kontrolya povedeniya v paradigmah go/nogo i novel. Tr. Pyatoj Vserossijskoj konferencii «Nelinejnaya dinamika v kognitivnyh issledovaniyah – 2017». Nizhnij Novgorod: IPF RAN. 2017. S. 176–178. (in Russian).
- Osetrov B.A., Salycheva A.V., Komisarenko A.A. Cerebral'naya gemodinamika pri ateroskleroticheskoj discirkulyarnoj encefalopatii razlichnoj vyrazhennosti. Nevrologicheskij vestnik im. V.M. Bekhtereva. 1998. № 1–2. S. 4. (in Russian).
- Shaw T.H., Funke M.E., Dillard M. et al. Event-related cerebral hemodynamics reveal target-specific resource allocation for both ‘‘go’’ and ‘‘no-go’’ response-based vigilance tasks. Brain and Cognition. 2013. V. 82. P. 265–273. DOI: 10.1016/j.bandc.2013.05.003
- Adamovskaya O.N., Ermakova I.V., Dogadkina S.B. Osobennosti nejrovegetativnoj i gumoral'noj regulyacii kognitivnoj deyatel'nosti u podrostkov pri ispol'zovanii elektronnyh ustrojstv. Acta Biomedica Scientifica. 2024. T. 9. №. 1. S. 85–95. (in Russian).
- Herff C., Heger D., Fortmann O. et al. Mental workload during n-back task—quantified in the prefrontalcortex using fNIRS. Frontiers in Human Neuroscience. 2014. V. 7 Article 935. DOI: 10.3389/fnhum.2013.00935
- Ostroumova T.M., Parfenov V.A., Ostroumova O.D. Arterial'naya gipertenziya i kognitivnye narusheniya: vzglyad s pozicij dokazatel'noj mediciny. Nevrologiya, nejropsihiatriya, psihosomatika. 2017. T. 9. № 4. S. 70–76. DOI: 10.14412/2074-2711-2017-4-70-76 (in Russian).
- Davidovich I.M., Afonaskov O.V., Staroverova Yu.K. Sutochnyj profil' arterial'nogo davleniya, pokazateli pamyati i vnimaniya u muzhchin molodogo vozrasta s arterial'noj gipertoniej. Kardiovaskulyarnaya terapiya i profilaktika. 2010. № 9. S. 20–24. (in Russian).
- Zaharov V.V. Narushenie pamyati v pozhilom vozraste: sovremennye vozmozhnosti profilaktiki i terapii. Russkij medicinskij zhurnal. 2012. № 8. S. 422–426. (in Russian).
- Prodius P.A., Bazhenov A.E., Berstneva M.D. Asimmetriya mozgovogo krovoobrashcheniya v bassejne vnutrennih sonnyh arterij u studentov pri kratkovremennoj umstvennoj nagruzke: svyaz' s effektivnost'yu kontrolya povedeniya. Zhurnal mediko-biologicheskih issledovanij. 2023. T. 11. № 2. S. 184–196. DOI: 10.37482/2687-1491 (in Russian).
- Balandin A.A., Zhigulev A.N., Balandina I.A. i dr. Prizhiznennaya morfometriya golovnogo mozga: metody i metodiki. Tekhnologii zhivyh sistem. 2025. T. 22. № 3. S. 17–26. DOI:10.18127/j20700997-202503-02 (in Russian).

