L.Kh. Pastushkova1, I.N. Goncharov2, E.S. Luchitskaya3, A.G. Goncharova4, D.N. Kashirina5, A.M. Nosovsky6, K.S. Kireev7, I.M. Larina8

1–6,8 FSBI State Scientific Center of the Russian Federation – Institute of Biomedical Problems of the Russian Academy of Sciences (Moscow, Russia)

7 FSBI “Research Institute of the Gagarin Cosmonaut Training Center” (Russia)

1 lpastushkova@mail.ru, 2 igorgoncharov@gmail.com, 3 e.luchitskaya@gmail.com, 4 goncharova.anna@gmail.com, 5 daryakudryavtseva@mail.ru, 6 collega1952@yandex.ru, 7 kir-kireev@yandex.ru, 8 irina.larina@gmail.com

The problem statement is relevant to study the influence of long-term space flights (SF) and landing on the levels of the proteomic marker ST2. The aim of the work is to study the relationship between the proteomic marker ST2 and the results of cardiac MRI after landing at the end of long-term six-month and annual SFs of Russian cosmonauts, with subsequent comparison between them.

Venous blood samples of 9 cosmonauts were studied before and after the SF to the ISS. Analysis of variance of ST2 protein levels in all cosmonauts revealed a significant increase in its concentration on the first day after the flight. The obtained data were compared with T1, T2 - mapping of the heart at the end of long SFs. On the 7th day of the recovery period, the content of ST2 protein decreased, approaching the background value. According to the results of mapping on the 4th day after the SF, changes in the structure of myocardial zones were revealed, corresponding to the direction of the landing overload vector.

The obtained results indicate transient myocardial overstretching during landing and an increased risk of cardiac fibrosis in the late stages after the space flight.

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