S.K. Pinaev1, A.Ya. Chizhov2, R.S. Pinaev3

1,3 Far Eastern State Medical University (Khabarovsk, Russia)

2 Peoples' Friendship University of Russia (Moscow, Russia);

Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (Moscow, Russia);

Medical ecological center "Mountain air XXI century" (Moscow, Russia)

1 pinaev@mail.ru, 2 ma21@mail.ru, 3 rusya.pinaev.00@mail.ru

Hemoblastosis in Russia accounts for 45.3% of childhood oncological morbidity. The available evidence on the relationship of hemoblastosis in children with solar radiation and smoke of various origins does not provide information on the critical stages of ontogenesis to the effects of these carcinogenic factors, which is necessary for the development of preventive measures.

The purpose of the study is identify a critical periods of adaptation to solar activity and smoke at the stages of ontogenesis in childhood hemoblastosis.

Time series based on official data on the incidence of hematological malignancies in the pediatric population of Russia for 23 years (1997-2019), as well as indicators of solar activity, the number of cars and the quantity of forest fires in the country, were subjected to regression-correlation analysis in 11 iterations with a delay (lag) from 0 to 10 years by the year of registration of neoplasms. Critical periods of adaptation was determined by subtracting the lag of the maximum value of the correlation coefficient from the average age of diagnosis of neoplasms.

A significant tendency to an increase in the incidence of hematological malignancies in children in Russia, including leukemia, was revealed (p <0.001). A link was established between the leukemia incidence and the activity of the Sun (critical period of adaptation at the age 3-4 years). The dependence of the non-Hodgkin's lymphomas incidence on solar activity was found (critical period of adaptation in the range from progenesis to the age of 2 years). A correlation was established between the Hodgkin's lymphoma incidence and forest fires, and Wolf numbers (critical period of adaptation to solar activity at the age 4-5 years). A significant trend towards a decrease in the incidence of childhood Hodgkin's lymphoma was revealed.

The incidence of all hematological malignancies in the pediatric population of Russia is associated with Wolf numbers. Critical periods of adaptation for various forms of neoplasms varies considerably. The increase of childhood leukemia incidence is presumably associated with the growing air pollution from automobile exhaust gases. The trend towards a decrease in the incidence of childhood Hodgkin's lymphoma may be due to an increase in the quality of life in the country.

Pinaev S.K., Chizhov A.Ya., Pinaev R.S. Critical periods of adaptation to Solar activity and smoke at the stages of ontogenesis in childhood hemoblastosis. Technologies of Living Systems. 2024. V. 21. № 4. Р. 64-71. DOI: https://doi.org/10.18127/j20700997-202404-07 (In Russian).

1. International Agency for Research on Cancer. International Incidence of Childhood Cancer. V. 3. Results. URL: http://iicc.iarc.fr/results/comparative.php
2. Portal ONCOLOGY.RU. Zlokachestvennye novoobrazovaniya v Rossii. URL: http://www.oncology.ru/service/statistics/malignant_tumors/ (in Russian).
3. Coste A., Hémon D., Orsi L., Boniol M., Doré J. F., Faure L., Clavel J., Goujon S. Residential exposure to ultraviolet light and risk of precursor B-cell acute lymphoblastic leukemia: assessing the role of individual risk factors, the ESCALE and ESTELLE studies. Cancer Causes Control. 2017. V. 28 (10). P. 1075–1083. DOI: 10.1007/s10552-017-0936-5
4. Lombardi C., Heck J.E., Cockburn M., Ritz B. Solar UV radiation and cancer in young children. Cancer Epidemiol. Biomarkers Prev. 2013. V. 22(6). P. 1118–1128. DOI: 10.1158/1055-9965.EPI-12-1316
5. Kirkeleit J., Riise T., Bjørge T., Christiani D.C., Bråtveit M., Baccarelli A., Mattioli S., Hollund B.E., Gjertsen B.T. Maternal exposure to gasoline and exhaust increases the risk of childhood leukaemia in offspring – a prospective study in the Norwegian Mother and Child Cohort Study. Br. J. Cancer. 2018. V. 119(8). P. 1028–1035. DOI: 10.1038/s41416-018-0295-3
6. Miligi L., Benvenuti A., Mattioli S., Salvan A., Tozzi G.A., Ranucci A., Legittimo P., Rondelli R., Bisanti L., Zambon P., Cannizzaro S., Kirchmayer U., Cocco P., Celentano E., Assennato G., Merlo D.F., Mosciatti P., Minelli L., Cuttini M., Torregrossa V., Lagorio S., Haupt R., Risica S., Polichetti A. SETIL Working Group, Magnani C. Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study. Occup. Environ. Med. 2013. V. 70(9). P. 648–655. DOI: 10.1136/oemed-2012-100951
7. Metayer C., Dahl G., Wiemels J., Miller M. Childhood Leukemia: A Preventable Disease. Pediatrics. 2016. V. 138 (Suppl 1). P. S45-S55. DOI: 10.1542/peds.2015-4268H
8. Cárceles-Álvarez A., Ortega-García J. A., López-Hernández F. A., Orozco-Llamas M., Espinosa-López B., Tobarra-Sánchez E., Alvarez L. Spatial clustering of childhood leukaemia with the integration of the Paediatric Environmental History. Environ. Res. 2017. V. 156. P. 605–612. DOI: 10.1016/j.envres.2017.04.019
9. Pinaev S.K., Chizhov A.Ya., Pinaeva O.G. Kriticheskie periody adaptacii k dymu i solnechnoj aktivnosti na etapah ontogeneza (obzor literatury). Ekologiya cheloveka. 2021. № 11. S. 4–11. DOI: 10.33396/1728-0869-2021-11-4-11 (in Russian).
10. Pinaev S.K., Torshin V.I., Radysh I.V., CHizhov A.YA., Pinaeva O.G. Ekologicheskie faktory, svyazannye s kolebaniyami chastoty novoobrazovanij u detej. Ekologiya cheloveka. 2021. № 6. S. 49–57. DOI: 10.33396/1728-0869-2021-6-49-57 (in Russian).
11. Bleyer A., Barr R., Ries L., Whelan J., Ferrari A. Cancer in Adolescents and Young Adults: Pediatric Oncology. Springer International Publishing AG. Second Edition. 2017. 825 p. DOI: 10.1007/978-3-319-33679-4
12. SILSO data/image, Royal Observatory of Belgium, Brussels. URL: http://www.sidc.be/silso/datafiles
13. Edinaya mezhvedomstvennaya informacionno-statisticheskaya sistema. Chislo sluchaev lesnyh pozharov. URL: https://fedstat.ru/indicator/31580 https://fedstat.ru/indicator/38497 (in Russian).
14. Federal'naya sluzhba gosudarstvennoj statistiki. Transport v Rossii. URL: https://rosstat.gov.ru/storage/mediabank/TRANSP.ZIP https://rosstat.gov.ru/storage/mediabank/obesp_legk_avto.xls (in Russian).
15. Ishkov V.N. Tekushchij 24 cikl solnechnoj aktivnosti v faze minimuma: Predvaritel'nye itogi i osobennosti razvitiya. Kosmicheskie issledovaniya. 2020. T. 58. № 6. S. 471–478. DOI: 10.31857/S0023420620060060 (in Russian).
16. Pinaev S.K., Chizhov A.Ya., Pinaeva O.G. Critical periods of adaptation to oncogenic environmental factors at the stages of ontogenesis. Actual Problems of Ecology and Environmental Management (APEEM 2021). E3S Web of Conferences 265. 06006 (2021). DOI: 10.1051/e3sconf/202126506006
17. Zheludkova O.G., Polyakov V.G., Rykov M.Yu., Susuleva N.A., Turabov I.A. Klinicheskie proyavleniya onkologicheskih zabolevanij u detej: prakticheskie rekomendacii. Pod red. V.G. Polyakova, M.YU. Rykova. SPb.: Tipografiya Mihaila Fursova. 2017. 52 s. (in Russian).
18. Chizhov A.YA., Pinaev S.K. Sistemnyj analiz vliyaniya solnechnoj radiacii i dyma lesnyh pozharov na risk lejkoza u detej. Radiaciya i risk. 2018. T. 27. № 4. S. 87–94. DOI: 10.21870/0131-3878-2018-27-4-87-94 (in Russian).
19. Saliev T., Begimbetova D., Masoud A.R., Matkarimov B. Biological effects of non-ionizing electromagnetic fields: Two sides of a coin. Prog. Biophys. Mol. Biol. 2019. V. 141. P. 25–36. DOI: 10.1016/j.pbiomolbio.2018.07.009
20. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. List of Classifications. Agents Classified by the IARC Monographs. V. 1–127. URL: https://monographs.iarc.fr/list-of-classifications
21. Jin M.W., Xu S.M., An Q., Wang P. A review of risk factors for childhood leukemia. Eur. Rev. Med. Pharmacol. Sci. 2016. V. 20(18). P. 3760–3764. URL: https://pubmed.ncbi.nlm.nih.gov/27735044
22. Filippini T., Heck J.E., Malagoli C., Del Giovane C., Vinceti M. A review and meta-analysis of outdoor air pollution and risk of childhood leukemia. J. Environ. Sci. Health C. Environ. Carcinog. Ecotoxicol. Rev. 2015. V. 33(1). P. 36–66. DOI: 10.1080/10590501.2015.1002999
23. Dimitrov B.D. Non-Hodgkin's lymphoma in US children: biometeorological approach. Folia Med. (Plovdiv). 1999. V. 41(1). P. 29–33. URL: https://pubmed.ncbi.nlm.nih.gov/10462916
24. Pinaev S.K. The influence of solar radiation and forest fires smoke on sporadic fluctuations of neoplasms incidence in children. RAD Conf. Proc. 2020. V. 4. P. 69–71. DOI: 10.21175/RadProc.2020.14
25. Dinand V., Arya L.S. Epidemiology of childhood Hodgkins disease: is it different in developing countries? Indian Pediatr. 2006. V. 43(2). P. 141–147. URL: https://www.ncbi.nlm.nih.gov/pubmed/16528110
26. Linabery A.M., Erhardt E.B., Fonstad R.K., Ambinder R.F., Bunin G.R., Ross J.A., Spector L.G., Grufferman S. Infectious, autoimmune and allergic diseases and risk of Hodgkin lymphoma in children and adolescents: a Children's Oncology Group study. Int. J. Cancer. 2014. V. 135(6). P. 1454–1469. DOI: 10.1002/ijc.28785
27. Chizhov A.YA., Pinaev S.K., Savin S.Z. Ekologicheski obuslovlennyj oksidativnyj stress kak faktor onkogeneza. Tekhnologii zhivyh sistem. 2012. № 1. S. 47–53. (in Russian).
28. Senger D.R., Li D., Jaminet S.C., Cao S. Activation of the Nrf2 Cell Defense Pathway by Ancient Foods: Disease Prevention by Important Molecules and Microbes Lost from the Modern Western Die. PLoS One. 2016. V. 11(2). P. e0148042. DOI: 10.1371/journal.pone.0148042
29. Greaves M. A causal mechanism for childhood acute lymphoblastic leukaemia. Nat. Rev. Cancer. 2018. V. 18(8). P. 471–484. DOI: 10.1038/s41568-018-0015-6
30. Pinaev C.K., Pinaeva O.G., Chizhov A.YA. Pervyj opyt terapii raka pishchevoda s ispol'zovaniem immunokorrektora Transfer Faktor™. Tekhnologii zhivyh sistem. 2014. №4. S. 59–62. (in Russian).
31. Immunoreabilitaciya pri infekcionno-vospalitel'nyh i somaticheskih zabolevaniyah s ispol'zovaniem Transfer Faktorov: metodicheskoe pis'mo. M.: Ministerstvo zdravoohraneniya i social'nogo razvitiya Rossijskoj Federacii. 2004. 34 s. (in Russian).