F.V. Donenko1, Yu.S. Lebedin2
1 N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation (Moscow, Russia)
2 HEMA LLC (Moscow, Russia)
1 donenko.f20010@yandex.ru
It is known that homeostasis in animals and humans is maintained by changing the configuration of serum proteins. It is suggested that the results of changing such a configuration of proteins should be a change in the constants of the interaction of proteins with body tissues. This should lead to impaired development (diseases) of these tissues. For example, in dry degenerative macular degeneration, the disease manifests itself in the tension of the macula with the formation of a “plateau” and subsequent rupture of the retina and blinding of the patient.
The aim of the work is to study the effects of autohemotherapy, which can restore the configuration of serum proteins, on the macula.
In this study, the reversibility of the state of tension of the macula and plateau was shown for the first time. Since 2014, the patient has received standard treatment for degenerative macular degeneration without positive dynamics. The technology of autohemotherapy was carried out. The results of tomography before and after 6 months are presented. The disappearance of macular tension and the disappearance of the plateau were noted.
It is concluded that it is necessary to continue studying this technology in degenerative macular degeneration.
Donenko F.V., Lebedin Yu.S. The first experience of using autohemotherapy technology for degenerative changes in the macula. Technologies of Living Systems. 2024. V. 21. № 3. Р. 67-73. DOI: https://doi.org/10.18127/j20700997-202403-07 (In Russian).
- Zaychikova S.G., Donenko F.V., Kormosh N.G., Kiselevskiy M.V. Transformatsiya kletok zlokachestvennoy melanomy V16 v melanotsity pod vozdeystviyem katepsina L1. Byulleten eksperimentalnoy biologii i meditsiny. 2020. T. 169. № 2. S. 217–220. (in Russian).
- Sitdikova S.M., Amandzholov B.S., Kiselevskiy M.V., Donenko F.V. Spetsifichnost retsidivirovaniya i metastazirovaniya eksperimentalnykh perevivayemykh opukholey kartsinomy Erlikha i melanomy V16. Byulleten eksperimentalnoy biologii i meditsiny. 2007. T. 143. № 1. S. 86–88. (in Russian).
- Sitdikova S.M., Amandzholov B.S., Serebryakova M.V., Zhdanovich M.Yu., Kiselevskiy M.V., Donenko F.V. Osobennosti vzaimodeystviya gemoglobina s belkami syvorotki krovi myshey s kartsinomoy Erlikha. Byulleten eksperimentalnoy biologii i meditsiny. 2006. T. 141. № 5. S. 563–566. (in Russian).
- Sitdikova S.M., Kiselevskiy M.V., Selchuk V.Yu., Amandzholov B.S., Kurbatova E.A., Donenko F.V. Otsenka effektivnosti immunoterapii kartsinomy yaichnikov myshey SAO-1 vaktsinami na osnove dendritnykh kletok. Byulleten eksperimentalnoy biologii i meditsiny. 2009. T. 147. № 2. S. 187–189. (in Russian).
- Donenko F.V., Kiselevskii M.V. Efferth T. Quantitative regulation of melanoma growth in the host by tumor-specific serpins in blood serum is a main reason for inefficient tumor treatment. Breakthroughs in melanoma research. Ed. Y. Tanaka. Intech, 2011. P. 509–532.
- Donenko F.V., Kiselewskii M.V., Efferth T. Surgical removal of primary tumors fosters distant metastasis. 7 May 2018. URL: https://stm.sciencemag.org/content/10/436/eaan3464/tab-e-letters
- Donenko F.V., Sitdikova S.M., Kabieva A.O., Moroz L.V. The characteristics of Ehrlich carcinoma recurrence and metastasis. Biull. Eksp. Biol. Med. 1992. V. 114. № 12. P. 652–654.
- Donenko F.V., Sitdikova S.M., Syrtsev A.V., Gradyushko A.T., Kiselevsky M.V., Serebryakova M.V., Efferth T. Hemoglobin-associated proteins isolated from blood serum of Еhrlich carcinoma-bearing mice. Int. J. Oncol. 2008. V. 32. № 4. P. 885–893. DOI: 10.3892/ijo.32.4.885
- Donenko F.V., Ziganshin R.H., Anisimova N.Y., Voyushin K.E., Sitdikova S.M., Amandzholov B.S., Kiselevskii M.V., Efferth T. Identification of serpin (alpha-1-antitrypsin) as serum growth inhibitory factor in murine ehrlich carcinoma by proteomics. Cancer Genomics Proteomics. 2010. V. 7. № 3. P. 147–156.
- Donenko F.V., Ziganshin R.K., Sitdikova S.M., Amandzholov B.S., Kiselevskii M.V., Efferth T. Induction of resistance to murine tumor development is associatedwith alterations in glycosylation of blood serum proteines// Mol. Med. Rep. 2009. V. 2. № 3. P. 487–495. DOI: 10.3892/mmr_00000126
- Shubina I.Zh., Akhmatova N.K., Donenko F.V., Kiselevskii M.V. Experimental Evaluation of Combined Immunotherapy for Tumors. Bull. Exper. Biol. Med. 2014. V. 157. № 5. P. 620–622.
- Kormosh N.G., Davidova T.V., Kopyltsov V.N., Serebryakova M.V., Kabieva A.O., Voyushin K.E., Sitdikova S.M., Amandzholov B.S., Kiselevskii M.V., Donenko F.V. Conformational changes in inter-α-trypsin inhibitor heavy chain 4 activate its tumor-specific activity in mice with B16 melanoma. Mol. Med. Rep. 2015. V. 12. № 3. P. 4483–4493.
- Donenko F.V., Kabiyeva A.O., Effert T. Syvorotochnyye opukholespetsificheskiye faktory – neobkhodimoye usloviye rosta opukholi v organizme. Klinicheskaya laboratornaya diagnostika. 2013. № 10. S.13–15. (in Russian).
- Donenko F.V., Kormosh N.G., Efferth T., Kiselevski M.V. Tumor-Specific Blood Serum Factors as Basis of Tumor Dormancy. Int. J. Biotechnol. for Wellness Industries. 2014. № 3. P. 1–3.
- Kormosh N.G., Ziganshin R.Kh., Shender V.O., Voyushin K.E., Donenko F.V. Changes in the Serum Protein Composition in Mice with Transplanted Ehrlich’s Carcinoma. Bull. Exper. Biol. Med. 2015. V. 158. № 4. P. 489–492.
- Donenko F.V., Sitdikova S.M., Dolzhikova Yu.I., Lebedin Yu.S. Izlecheniye myshey s rasprostranennoy adenokartsinomoy yaichnikov SaO1 s pomoshchyu belkov syvorotki krovi. Byulleten eksperimentalnoy biologii i meditsiny. 2021. T. 172. № 8. S. 2–6. (in Russian).
- Donenko F.V., Moroz L.V. Phenomenon of tumor growth stability in the host's body. New approach to growth and treatment of tumors. Vestn. Ross. Akad. Med. Nauk.1995. № 4. P. 14–16.
- Donenko F.V., Sitdikova S.M., Moroz L.V. The role of serum humoral factors in metastasis and recurrence of Ehrlich carcinoma in mice. Biull. Eksp. Biol. Med. 1997. V.124. № 10. P. 443–445.
- Trishin A.V., Zhdanovich M.I., Savvateeva L.V., Toptygin A.I., Donenko F.V., Kiselevskiĭ M.V., Kurbatova E.A., Gruber I.M., Elkina S.I., Kalina N.G. Protease activity of Klebsiella pneumoniae of different virulence. Zh. Mikrobiol. Epidemiol. Immunobiol. 2004. V. 4. P. 7–11.
- Sitdikova S.M., Kiselevskii M.V., Sel'chuk V.Y., Amandzholov B.S., Kurbatova E.A., Donenko F.V. Evaluation of immunotherapy efficiency in mouse CaO-1 ovarian carcinoma treated by vaccines based on dendritic cells. Bull. Exp. Biol. Med. 2009. V.147. № 2. P. 226–228.
- Donenko F.V. Profilaktika vozrastnykh opukholevykh protsessov na primere rosta gepatomy myshey linii SVA. Tekhnologii zhivykh sistem. 2023. T. 20. № 3. S. 65–72. (in Russian).
- Donenko F.V. Faktory. vliyayushchiye na rost opukholi i podkhody k ne tsitotoksicheskomu metodu eye lecheniya. Alternativnoye mneniye. Onkoginekologiya. 2021. № 4. S. 4–17. (in Russian).