L.D. Egamberdieva1, Yu.S. Pokrovskaya2, G.S. Aslan3, T.Yu. Pokrovskaya4
1–3 Kazan State Medical University (Kazan, Russia)
4 Kazan National Research Technical University named after A. N. Tupolev (Kazan, Russia)
1 lutsia1@yandex.ru, 2 iu.pk@bk.ru, 3 guzelo-aslan@mail.ru, 4 vip89@mail.ru
The presented work presents data on theories of the pathogenesis of uterine fibroids, leading to disruption of a woman’s reproductive function and, accordingly, to infertility, as well as methods of surgical treatment of this pathology with their advantages and disadvantages. The analysis of foreign and domestic literature sources demonstrated that surgical intervention is aimed at reducing clinical manifestations, restoring the menstrual cycle and preserving fertility. The article also discusses the mechanisms affecting reproductive function and pregnancy. An assessment was made of the general condition of women, their psychological portrait after surgical interventions, the quality of rehabilitation and the hormonal profile of patients involved and not involved in sports and an active lifestyle.
The general condition of the women and their psychological portrait were assessed using questionnaires with such parameters as levels of pain, discomfort, anxiety, and fatigue. The questionnaire contained 10 main questions of a closed and semi-closed type, including in each question from 2 to 4 answer options, which were aimed at clarifying the subjective state of respondents regarding physical health and emotional state, as well as at verifying their functional state, identifying problems that arise during rehabilitation period. The level of ovarian reserve was assessed by the level of anti-Mullerian hormone, estradiol before and after surgical treatment, ovarian volume and the number of antral follicles after surgery. The course of the rehabilitation period was assessed by such parameters as the presence of complications (active bleeding, irritation of the obturator nerve, necrosis of the myomatous node), duration of hospitalization and rehabilitation, volume of intraoperative blood loss, duration of disability, duration of fever and time of normalization of peripheral blood parameters.
The obtained objective information about the condition of the patients in the postoperative period and the traced dynamics of their recovery determined the cause-and-effect relationship between sports and the quality and course of the rehabilitation process after surgery: physical education does not affect the preservation of the ovarian reserve after surgical treatment - it decreases slightly in each group of women studied, but remains within the reference values. In women leading an active lifestyle, the course of the rehabilitation process after surgical interventions improves: the level of pain, discomfort, anxiety and fatigue decreases faster, the duration of hospitalization and rehabilitation, the febrile period, and the recovery of peripheral blood parameters are shorter. Thus, women who play sports quickly return to their usual lifestyle.
According to the authors, the results obtained have practical significance and can be used for implementation in medical practice for the purpose of better rehabilitation, continuation of a woman’s reproductive function in the postoperative period and significantly increasing the importance of leading an active lifestyle.
Egamberdieva L.D., Pokrovskaya Yu.S., Aslan G.S., Pokrovskaya T.Yu. Analysis of the course of rehabilitation and reproductive outcome of women athletes and ordinary women after myomectomy. Technologies of Living Systems. 2024. V. 21. № 2. Р. 30-38. DOI: https://doi.org/10.18127/j20700997-202402-03 (In Russian).
- Vinokurova E.A., Gorodnicheva I.E., Kiseleva M.A. Effektivnost menopauzalnoy gormonalnoy terapii u zhenshchin s menopauzalnym sindromom. Doktor.Ru. 2020. T. 19. № 1. S. 38–41. (in Russian).
- Yashchuk A.G., Musin I.I., Gumerova I.A. Sovremennyye aspekty v izuchenii etiologii miomy matki. Rossiyskiy vestnik akushera-ginekologa. 2019. T. 19. № 3. S. 49–56. (in Russian).
- Giuliani E., As-Sanie S., Marsh E.E. Epidemiology and management of uterine fibroids. Int. J. Gynaecol. Obstet. 2020. V. 149. № 1. P. 3–9.
- Radzinskii V.E., Fuks A.M. Ginekologiya. M.: Media. 2016. S. 497–505. (in Russian).
- Akhmedova N.M. Funktsionalnoye sostoyaniye gipofizarno-yaichnikovoy sistemy u zhenshchin s miomoy matki. Zhurnal povtornogo zdorovia. 2020. T. 1. № 5. S. 8–10. (in Russian).
- Bezhenar V.F., Linde V.A., Arakelyan B.V., Sadykova E.E., Reznik M.V., Tarasenkova V.A. Mioma matki i fertilnost: sovremennyy vzglyad na problemu (obzor literatury). Zhurnal akusherstva i zhenskikh bolezney. 2022. T. 71. № 2. S. 79–86. (in Russian).
- Doroha O., Iarotskyi M., Iarotska I., Semeniuk L., Nikitina O. Uterine fibroids impact on fertility and pregnancy outcome. EUREKA: Health Sciences. 2020. № 2. P. 52–58.
- Karamyan R.A., Ordiyants I.M., Khorolskiy V.A., Asatryan D.R. Mioma matki: vzglyad na problemu. Meditsinskiy vestnik Yuga Rossii. 2022. T.13. №2. S.18-25. (in Russian).
- Baranov V.S., Osinovskaya N.S., Yarmolinskaya M.I. Pathogenomics of Uterine Fibroids Development. Int. J. Mol. Sci. 2019. V. 20. № 24. P. 6151.
- Katorkina E.S., Shatunova E.P. Sovremennyye aspekty etiologii i patogeneza miomy matki. Nauka i innovatsii v meditsine. 2017. T. 1. № 5. S. 6–12. (in Russian).
- Yang Q., Ciebiera M., Bariani M.V., Ali M., Elkafas H., Boyer T.G., Al-Hendy A. Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment. Endocr. Rev. 2022. V. 43. № 4. P. 678–719.
- Marinkin I.O., Solyanikov D.A., Volchek A.V., Mikhaylova E.S., Piven L.A., Aydagulova S.V. Immunofermentnoye issledovaniye soderzhaniya interleykinov v opukholevykh supernatantakh u patsiyentok s mnozhestvennoy miomoy matki. Uralskiy meditsinskiy zhurnal. 2021. T. 20. № 6. S. 51–56. (in Russian).
- Solovyeva A.V., Fedotov N.G. Mioma matki: reproduktivnoye zdorovye zhenshchin posle operativnogo lecheniya. Akusherstvo i ginekologiya: Novosti. Mneniya. Obucheniya. 2020. T. 8. № 29. S. 112–115. (in Russian).
- Britten J.L., Malik M., Lewis T.D., Catherino W.H. Ulipristal Acetate Mediates Decreased Proteoglycan Expression Through Regulation of Nuclear Factor of Activated T-Cells (NFAT5). Reprod. Sci. 2019. V. 26. № 2. P. 184–197.
- Shapovalova A.I. Leiomioma matki i reproduktsiya. Zhurnal akusherstva i zhenskikh boleznei. 2019. T. 68. № 1. S. 93–101. (in Russian).
- Savelyeva G.M., Breusenko V.G. Ginekologiya. M.: GEOTAR-MED. 2004. S. 474. (in Russian).
- Petrov I.A., Tikhonovskaya O.A., Okorokov A.O., Kupriyanova I.I., Fateyeva A.S., Petrova M.S., Logvinov S.V. Profilakticheskaya salpingektomiya. Akusherstvo i ginekologiya. 2016. T. 2. S. 36–42. (in Russian).
- Plekhanov A.N., Bezhenar V.F., Epifanova T.A., Bezhenar F.V. Sravnitelnaya kharakteristika metodov gemostaza pri vlagalishchnoy gisterektomii. Kubanskiy nauchnyy meditsinskiy vestnik. 2019. T. 26. № 6. S. 61–69. (in Russian).
- Eliseyev D.E., Kholodova Zh.L., Dobrokhotova Yu.E., Ovcharenko D.V., Kholodova Ya.G. Bezopasnaya gisterektomiya. Kremlevskaya meditsina. Klinicheskii? vestnik. 2023. T. 1. S. 61–71. (in Russian).
- Podzolkova N.M., Korennaya V.V., Koloda Yu.A., Kuznetsov R.E., Ignatchenko O.Yu. Funktsionalnyye iskhody miomektomii. Problemy reproduktsii. 2020. T. 26. № 3. S. 31–38. (in Russian).
- Borah B.J., Yao X., Laughlin-Tommaso S.K., Heien H.C., Stewart E.A. Comparative Effectiveness of Uterine Leiomyoma Procedures Using a Large Insurance Claims Database. Obstet. Gynecol. 2017. V. 130. № 5. P. 1047–1056.
- Timchenko M.A., Olovyannikov Yu.S., Nikolayeva M.G. Metody lecheniya simptomnoy miomy matki cherez prizmu vremeni. Mat i Ditya v Kuzbasse. 2023. T. 1. № 92. S. 20–29. (in Russian).
- Chaava L.I., Kakhiani E.I., Tsygan V.N., Drygin A.N., Pakhomova M.A. Endokrinno-metabolicheskiye posledstviya operativnykh vmeshatelstv pri miome matki: patogeneticheskaya kharakteristika. Pediatr. 2019. T. 10. № 2. S. 75–82. (in Russian).
- Yushchenko M.A., Mozes V.G., Rudayeva E.V., Elgina S.A., Mozes K.B., Rybnikov S.V., Pomykana T.E., Tsenter Ya. Postembolizatsionnyy sindrom posle embolizatsii matochnykh arteriy pri miome matki. Mat i ditya v Kuzbassse. 2023. T. 2. № 93. S. 78–84. (in Russian).
- Kim A., Arabkhazaeli M., Ulrich A., Lerner V., Shin J.H. Updates in uterine artery embolization for leiomyomas. Curr. Opin. Obstet. Gynecol. 2020. V. 32. № 4. P. 269–276.
- Kohi M.P, Spies J.B. Updates on uterine artery embolization. Semin Intervent Radiol. 2018. V. 35. P. 48–55.
- Stewart J.K. Uterine Artery Embolization for Uterine Fibroids: A Closer Look at Misperceptions and Challenges. Tech. Vasc. Interv. Radiol. 2021. V. 24. № 1. P. 100725.2
- Ibragimova A.R., Ivanova T.V., Trebunskikh A.S., Ayupova N.T., Blazhnova E.M., Tselkovich L.S., Balter R.B. Analiz izmeneniya ovarialnogo rezerva u zhenshchin posle razlichnykh vidov lecheniya miomy matki. Sovremennaya nauka: aktualnyye problemy teorii i praktiki. Ser. Estestvennyye i Tekhnicheskiye Nauki. 2022. T. 11. S. 192–198. (in Russian).
- Nagayeva O.A., Shcherbakova L.N., Revina D.B., Alekseyenkova M.V., Zaytseva N.I., Kirillova K.I., Samokhodskaya L.M., Panina O.B. Polimorfizm genov predraspolozhennosti k aterosklerozu. faktorov angiogeneza i funktsii endoteliya i privychnoye nevynashivaniye beremennosti neyasnogo geneza. Tekhnologii zhivykh sistem. 2023. T. 17. № 4. S. 53–63. (in Russian).
- Gershteyn E.S., Kushlinskiy D.N., Tereshkina I.V., Utkin D.O., Kushlinskiy N.E. Klinicheskoye znacheniye belka programmiruyemoy kletochnoy gibeli PD-1 i ego liganda PD-L1 pri rake yaichnikov (obzor). Tekhnologii zhivykh sistem. 2020. T. 17. № 3. S. 5–15. (in Russian).