N.A. Loginova1, N.V. Panov2

1,2 Institute of higher nervous activity and neurophysiology RAS (Moscow, Russia)

1 nadezhda.loginova1982@gmail.com, 2 nikolay.panov1966@yandex.ru

Cortexin is a multicomponent drug consisting of proteins and stabilized fragments of a DNA. It is used in the clinic for treatement patients after a stroke. After a stroke, in addition to the symptoms associated with neurological deficiency, patients often have anxiety and depression.

The aim of the work was to study the effect of cortexin on changing the behavior of rats in the "open field" and "elevated plus maze" tests after modeling an cerebral ischemia using the photochemical thrombosis method.

After an ischemic stroke, motor and exploratory activity decreased in rats, and anxiety increased. The introduction of cortexin led to the restoration of exploratory behavior in the "elevated plus maze" test.

Cortexin can be used in clinical practice not only to compensate for neurological deficits, but also as an anxiolytic.

Loginova N.A., Panov N.V. Effect of cortexin on anxiety changes in rats after modeling cerebral ischemia in the neocortex. Technologies of Living Systems. 2024. V. 21. № 1. Р. 55-62. DOI: https://doi.org/10.18127/j20700997-202401-05 (In Russian)

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