M.Yu. Ravaeva1, I.V. Cheretaev2, E.N. Chuyan3

1–3 FSAEI HE “V.I. Vernadsky Crimean Federal University” (Simferopol, Russia)

1 ravaevam@yandex.ru, 2 cheretaev86@yandex.ru, 3 elena-chuyan@rambler.ru

The investigation is a continuation of series works devoted to the study of microcirculatory and tissue processes in the skin of rats under stress of varying duration and the influence of extremely high frequency electromagnetic radiation (EHF EMR). The hypothesis of the study is that the antistress effect of EHF EMR is associated with changes in energy tissue metabolism and microcirculation processes.

The aim of the study was to investigate the effect of EHF EMR on microcirculatory and metabolic processes in the skin of rats under stress of different duration.

The methods of laser Doppler flowmetry and fluorescence spectroscopy were used for analysis of microcirculatory and metabolic processes in the skin of rats under acute and chronic stress and under the action of EHF EMR. It was found that the change in the fluorescence of NADH and FAD coenzymes under stress of different duration is a non-specific reaction, since their orientation is the same, but with chronic stress it is more pronounced, as evidenced by a decrease in the redox ratio index by 10 % (p < 0.05) relative to those in the acute stress group.

EHF EMR using in combination with stress leads to the optimization of microcirculatory processes: the leveling of vasoconstriction caused by hypokinetic stress and vasodilation caused by acute stress, which is reflected in an increase in the intensity of oxidative phosphorylation.

The results of this research are directed at solving an important interdisciplinary problem in such fields of science as physiology, biophysics, medicine, rehabilitation – the study of the mechanisms of action of EHF EMR underlying its high biological and therapeutic activity. These studies are relevant because humans and animals are constantly exposed to stress factors: pain, temperature, emotional, physical, etc. The high mortality rate in stress-induced injuries of the human body attracts the attention of scientists from different fields of medicine and biology to this problem and makes it urgent to study the mechanisms of stress reaction development at different levels of the body (from the cell to the whole organism) in order to further introduce EHF EMR into practice as a factor limiting the development of stress pathological forms.

Ravaeva M.Yu., Cheretaev I.V., Chuyan E.N. The effect of low-intensity extremely high frequency electromagnetic radiation on microcirculatory and metabolic processes in the skin of rats under stress of different duration. Technologies of Living Systems. 2023. V. 20. № 4. Р. 112-120. DOI: https://doi.org/10.18127/j20700997-202304-11 (In Russian).

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