Yu.I. Matveev1, E.V. Averyanova2

1 Emanuel Institute of Biochemical Physics RAS (Moscow, Russia)

2 Biotechnology Biysk Technological Institute (branch) of the Altay State Technical University (Biysk, Russia)

1 yu.matveev@mail.ru, 2 averianova.ev@bti.secna.ru

Circulatory system diseases, including myocardial infarction, stroke, and ischemic heart disease, which develop due to athero are the main cause of death in the population over 65 years of age in Russia and the European Union countries with a probability of about 72% Sclerotic damage to the walls of blood vessels caused by lipid and protein metabolism disorders, which promotes the formation of atherosclerotic plaques in the walls of blood vessels. The growth of these dense connective tissue formations leads to a narrowing of the vascular lumen, and their rupture contributes to the formation of a clot at this point, which can completely clog the vessel.

The aim of the work is to estimate the total maturation time of atherosclerotic plaques using a specific lipid marker of atherosclerosis – oxidized form of low density lipoproteins by calculation and analytical method.

Issues of aggregation of binary biopolymer systems in blood vessels, taking into account the statistics of cardiovascular diseases and the influence of various factors on coefficient A, taking into account the density of atherosclerotic plaque, in the concentration ratio of the components of the binary system. The equation for estimating the growth rate of atherosclerotic plaques, parameters of which allow to establish connection with the results of the most informative measurements of concentrations of lipoproteins of high and low density (including their oxidized form) and other factors (medication, disease, bad habits, etc.). The article analyses some statistics of cardiovascular diseases of patients aged from 28 to 106 years.

The proposed dependencies on calculation of the rate of formation of atherosclerotic plaques allow analytically to take into account the influence of various factors on the development of atherosclerosis, which should be based on reliable methods of recording the parameters included in them.

Matveev Yu.I., Averyanova E.V. Estimate of growth rates of atherosclerotic plaques in the walls of bloods in the walls of blood vessels. Technologies of Living Systems. 2023. V. 20. № 4. Р. 64-71. DOI: https://doi.org/10.18127/j20700997-202304-06 (In Russian).

1. Maksimova T.M., Lushkina N.P. Sostav prichin smerti pozhilogo naseleniya kak pokazatel kachestva meditsinskoy pomoshchi. Demoskop Weekly. 2009. T. 369. S. 370. (in Russian).
2. Armaganov A.G., Pirogov A.N., Sedov A.A. Multisensornyy registrator v sisteme distantsionnogo monitoringa patsiyentov. Tekhnologii zhivykh sistem. 2019. T. 16. № 4. S. 53–59. (in Russian).
3. Vaysman D.Sh., Aleksandrova G.A., Leonov S.A., Savina A.A. Dostovernost pokazateley i struktury prichin smerti ot bolezney sistemy krovoobrashcheniya v Rossiyskoy Federatsii pri mezhdunarodnykh sopostavleniyakh. Sovremennyye problemy zdravookhraneniya i meditsinskoy statistiki. 2019. № 3. S. 69–84. (in Russian).
4. Lotrič Dolinar A., Sambt J., Korenjak-Černe S. Clustering EU countries by causes of death. Population Research and Policy Review. 2019. V. 38. P. 157–172.
5. Movsisyan N.K., Vinciguerra M., Medina-Inojosa J.R., Lopez-Jimenez F. Cardiovascular diseases in central and eastern Europe: a call for more surveillance and evidence-based health promotion. Annals of global health. 2020. V. 86. Is. 1. P. 21.
6. Kremneva L.V., Shalayev S.V. Modifitsirovannyye lipoproteiny nizkoy plotnosti: aterogennaya i provospalitelnaya aktivnost. rol v patogeneze ostrykh koronarnykh simptomov. Rossiyskiy kardiologicheskiy zhurnal. 2004. № 2. S. 70–75. (in Russian).
7. Torkhovskaya T.I., Kudinov V.A., Zakharova T.S., Markin S.S. Disfunktsionalnyye lipoproteiny vysokoy plotnosti: rol v aterogeneze i potentsialnyye misheni dlya fosfolipidnoy terapii. Kardiologiya. 2018. T. 58. № 3. S. 73–83. (in Russian).
8. Ragino Yu.I., Nikitin Yu.P. Okislennyye i strukturno-modifitsirovannyye lipoproteiny nizkoy plotnosti pri ateroskleroze. Ateroskleroz. 2022. T. 2. № 1. S. 3–19. (in Russian).
9. Frąk W., Wojtasińska A., Lisińska W., Młynarska E., Franczyk B., Rysz J. Pathophysiology of Cardiovascular Diseases: New Insights into Molecular Mechanisms of Atherosclerosis, Arterial Hypertension, and Coronary Artery Disease. Biomedicines. 2022. V. 8. Is. 10. P. 1938.
10. Tohirova J., Shernazarov F. Atherosclerosis: causes, symptoms, diagnosis, treatment and prevention. Science and innovation. 2022. V. 1. Iss. D5. P. 7–12.
11. Metelskaya V.A. Funktsionalnaya mnogogrannost lipoproteinov vysokoy plotnosti: poisk zolotoy serediny. Ateroskleroz. 2021. T. 17. № 2. S. 61–71. (in Russian).
12. Hamer M., O’Donovan G., Stamatakis E. High-density lipoprotein cholesterol and mortality: too much of a good thing? Arteriosclerosis, thrombosis, and vascular biology. 2018. V. 38. Is. 3. P. 669–672.
13. Saito I., Yamagishi K., Kokubo Y., Yatsuya H., Iso H., Sawada N., Tsugane S. Non-high-density lipoprotein cholesterol and risk of stroke subtypes and coronary heart disease: the Japan public health center-based prospective (JPHC) study. Journal of atherosclerosis and thrombosis. 2020. V. 27. Is. 4. P. 363–374.
14. Panasenko O.M., Torkhovskaya T.I., Gorudko I.V. et al. The Role of Halogenative Stress in Atherogenic Modification of Low-Density Lipoproteins. Biochemistry. 2020. V. 85. Is. 1. P. 34–55.
15. Torzewski M. The Initial Human Atherosclerotic Lesion and Lipoprotein Modification – A Deep Connection. International Journal of Molecular Sciences. 2021. V. 22. P. 11488.
16. Vorobyeva E.N., Simonova G.I., Vorobyev R.I., Leshchenko I.Zh. Svobodno-radikalnoye okisleniye i ateroskleroz. Ateroskleroz. 2022. T. 6. № 2. S. 20–27. (in Russian).
17. Tertov V.V. Mnozhestvenno-modifitsirovannyye lipoproteidy nizkoy plotnosti. tsirkuliruyushchiye v krovi cheloveka: Diss. … dokt. biol. nauk. M. 2000. 333 s. (in Russian).
18. Matveyev Yu.I., Averianova E.V. Ispolzovaniye analiticheskikh podkhodov dlya otsenki vliyaniya lipidov na vremya perevarivaniya belkov i uglevodov pishchi. Polzunovskiy vestnik. 2023. № 3. S. 7–12. (in Russian).
19. Matveyev Yu.I., Averianova E.V. Ob agregatsii v binarnykh biopolimernykh sistemakh. Izvestiya vuzov. Ser. Prikladnaya khimiya i biotekhnologiya. 2020. T. 10. № 2. S. 223–231. (in Russian).
20. Berns S.A., Shmidt E.A., Chuvichenko O.V., Khomyakova T.A., Nagirnyak O.A., Barbarash O.A. Okislitelnyy metabolizm lipoproteinov u bolnykh multifokalnym aterosklerozom. Doktor. RU. 2016. T. 119. № 2. S. 70–74. (in Russian).
21. Panasenko O.M., Sergiyenko V.I. Svobodno-radikalnaya modifikatsiya lipoproteinov krovi i ateroskleroz. Biologicheskiye membrany. 1993. T. 10. № 4. S. 341–361. (in Russian).
22. Gindin V.P. Psikhopatologiya v russkoy literature. M.: PER SE. 2012. 224 s. (in Russian).
23. Kuznetsov V.A., Yaroslavskaya E.I. Rol ultrazvuka v vyyavlenii surrogatnykh markerov ateroskleroza. Ultrazvukovaya i funktsionalnaya diagnostika. 2011. № 1. S. 98–104. (in Russian).
24. Kayumova G.Kh., Razin V.A. Gendernyye osobennosti ateroskleroza i dislipidemii pri ostrom koronarnom sindrome. Materialy VIII Mezhdunar. kongressa «Kardiologiya na perekrestke nauk». 24-26 maya 2017 g., g. Tyumen. S. 124. (in Russian).
25. Tokluyeva L.R. Sravnitelnaya otsenka klinicheskikh. biokhimicheskikh i funktsionalnykh parametrov u asimptomnykh bolnykh s povrezhdennymi i nepovrezhdennymi pokryshkami nestabilnykh gemodinamicheski znachimykh ateroskleroticheskikh blyashek sonnykh arteriy: Diss. … kand. med. nauk. M. 2016. 89 s. (in Russian).