M.A. Yakovleva1, V.N. Gorshenev2, A.E. Dontsov3, A.A. Olkhov4

1–4 Federal State Budgetary Institution of Science
Institute of Biochemical Physics named after N.M. Emanuel RAS (Moscow, Russia)

The creation of biodegradable polymers has significantly influenced the development and rapid growth of various technologies in modern medicine. Currently, biodegradable polymers are used in two main medical applications: tissue engineering and targeted drug delivery. The criterion for the selection of biodegradable polymers is that the degradation products of the polymer must be non-toxic, and the degradation rate and mechanical properties of the material must correspond to the biomaterial of a living organism. The creation of biocomposites based on biodegradable polymers with dosage forms and antioxidants allows their dosed prolonged release during the destruction of the polymer matrix. Which, in turn, when used in medicine can provide dosed delivery of dosage forms to the area of diseases. Melanin is widely known for its strong antioxidant properties. In addition, it is used as an antimutagenic agent for the prevention of genetic and ontogenetic consequences of radiation exposure. The purpose of the work was to develop methods for the manufacture of polymer compositions with melanins with antioxidant activity and to study changes in the properties of composites during their destruction. To study the properties of biocomposites, the following methods were used – spectrophotometric, fluorescent analysis, thermogravimetric analysis, differential scanning calorimetry. Several different mixing schemes have been tested to obtain biocomposites with an included antioxidant. It has been shown that the natural antioxidants melanin form composites with biodegradable polymers: polyhydroxybutyrate (PHB), polylactide (PLA) and polycaprolactone (PCL), and the released melanin does not lose its antioxidant properties during the biodegradation of such composites. An approach to the creation of polymeric biocomposites containing biologically active substances based on the use of the technique of mixing components in an ultrasonic field and thermally stimulated microwave heating is proposed.

Yakovleva M.A., Gorshenev V.N., Dontsov A.E., Olkhov A.A. Modification of biodegradable polymers with natural antioxidants. Technologies of Living Systems. 2022. V. 19. № 4. Р. 52-59. DOI: https://doi.org/10.18127/j20700997-202204-05 (In Russian)

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