T.Ya. Korchina1, V.I. Korchin2

1,2 Khanty-Mansiysk State Medical Academy (HMGMA) (Khanty-Mansiysk, Russia)

The population of most of the territories of the Khanty-Mansiysk Autonomous Okrug (Khanty-Mansiysk Autonomous Okrug) is provided with poor-quality drinking water: artesian water is only chlorinated. The natural waters of the Khanty-Mansi Autonomous Okrug contain increased concentrations of Fe and Mn, the excessive accumulation of which in the human body can activate the processes of lipid peroxidation (LPO). It has been established that the plant-based flavonoid dihydroquercetin has a powerful antioxidant activity, and the zosterin sorbent contains pectins capable of removing heavy metals from the human body.

Purpose – analysis of the correction of indicators of oxidative metabolism with dihydroquercetin and zosterin in the population of the Khanty-Mansi Autonomous Okrug who consume poorly purified water.

We examined 71 adult residents of the cities of the Khanty-Mansi Autonomous Okrug with poor-quality water treatment: 29 (41%) men and 42 (59%) women. The average age was 38.3 ± 8.9 years. In the blood, LPO products were determined: lipid hydroperoxides, thiobarbituric acid, active products, and parameters of the body's antioxidant defense (AOD): general antioxidant activity and thiol status. Representatives of the 1st group (n = 38) took dihydroquercetin (DHA) for a month, and the 2nd group (n = 33) – DHA + zosterin.

The previously studied LPO parameters exceeded the optimal values, and the AOD turned out to be less than them. After taking DHA and DHA + zosterol for a month, there was a significant decrease in LPO indicators (p = 0,049 – p <0,001) and an increase in AOD parameters (p = 0,036 – p <0,001), more pronounced in people of group 2.

In order to restore the functional reserves of the metabolic status, improve health, improve the quality of life, and increase its duration in residents of regions with poor-quality water treatment, it is recommended to carry out correction with bioantioxidants and adsorbents of plant origin.

Korchina T.Ya., Korchin V.I. Corrective effect of dihydroquercetin and zosterin on oxidative metabolism in persons living in the cities of the Khanty-Mansiya autonomous district with low quality of water purification. Technologies of Living Systems. 2021. V. 18. № 4.  Р. 56−72. DOI: https://doi.org/10.18127/j20700997-202104-07 (In Russian)

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