Y.I. Gurfinkel¹, S.T. Matskeplishvili², Y.A. Remizova³, A.A. Pigurenko4, N.D. Novikov5, K.K. Kamilov6, A.M. Tishin7
1 Medical Research and Education Centre, Lomonosov Moscow State University (Moscow, Russia); Space Research Institute Russian Academy of Sciences (Moscow, Russia)
2 Medical Research and Education Centre, Lomonosov Moscow State University (Moscow, Russia)
3-5,7 Faculty of Physics, Lomonosov Moscow State University (Moscow, Russia)
6 Faculty of Physics, Lomonosov Moscow State University (Moscow, Russia);
Amirkhanov Institute of physics, Russian Academy of Sciences (Makhachkala, Russia)
Endothelial cells line the inner surface of human blood vessels, releasing nitrogen monoxide and other active substances, which play an important role in the regulation of blood pressure, blood viscosity and flow. Recent studies have shown that endothelial cells are sensitive to electromagnetic fields (EMF).
Objective – to determine the effect of weak electromagnetic fields on endothelial function, blood pressure and heart rate in healthy volunteers.
In total, the study included 35 healthy young people aged 18 to 31 years. Each measurement included determination of endothelial function, measurement of blood pressure and heart rate using the “AngioCheck” system (Russia). Participants have been divided into two groups. In the first group, 4 consecutive measurements were taken against the background of exposure to EMF for an hour and the 5th measurement 30 minutes after the exposure of EMF generated with MHS-5200P system (Mingle Instrument, Hong Kong). In the second group, the same measurements were performed in the same sequence, but without exposure to EMF. The study was approved by the Ethics Committee of the Medical Scientific and Educational Center of Lomonosov Moscow State University.
The results of the study showed the most pronounced effect when exposed to a magnetic field with a frequency of 800 Hz and amplitude of 0.05 mT. All the parameters of EF after the initial measurements significantly increased in comparison with the initial ones, and even 30 minutes after the exposure was turned off, the increase in EF continued.
In practical medicine, the use of EMF with frequencies revealed in our study can be useful for patients with diabetes mellitus, coronary heart disease, chronic heart failure, when endothelial dysfunction is present.
Gurfinkel Y.I., Matskeplishvili S.T., Remizova Y.A., Pigurenko A.A., Novikov N.D., Kamilov K.K., Tishin A.M. Effects of weak electromagnetic fields on endothelial function of young healthy people. Technologies of Living Systems. 2021. V. 18. № 2. Р. 5–14. DOI: https://doi.org/10.18127/j20700997-202102-01 (In Russian).
- Stoupel E., Abramson J., Domarkiene S., Shimshoni M., Sulkes J. Space proton flux and the temporal distribution of cardiovascular deaths. Int. J. Biometeorol. 1997. V. 40. P. 113–116. http://dx.doi.org/10.1007/s004840050029
- Vencloviene J., Babarskiene R., Slapikas R. The association between solar particle events, geomagnetic storms, and hospital admissions for myocardial infarction. Nat. Hazards. 2013. V. 65. P. 1–12. http://dx.doi.org/10.1007/s11069-012-0310-6
- Gurfinkel Y.I., Vasin A.L., Pishchalnikov R.Y., Sarimov R.M., Sasonko M.L., Matveeva T.A. Geomagnetic storm under laboratory conditions: randomized experiment. Int. J. Biometeorol. 2018. V. 62. P. 501–512. https://doi.org/10.1007/s00484-017-1460-8
- Gurfinkel Yu.I., Ozheredov V.A., Breus T.K., Sasonko M.L. The Effects of Space and Terrestrial Weather Factors on Arterial Stiffness and Endothelial Function in Humans. J. Biofizika. 2018. V. 63. № 2. P. 402–411.
- Virdis A., Ghiadoni L., Taddei S. Effects of antihypertensive treatment on endothelial function. Curr. Hypertens Rep. 2011. V. 13. P. 276–281.
- Schulz E., Gori T., Munzel T. Oxidative stress and endothelial dysfunction in hypertension. J. Hypertens. Res. 2011. V. 34 (6). P. 665.
- Daish C., Blanchard R., Fox K., Pivonka P., Pirogova E. The Application of Pulsed Electromagnetic Fields (PEMFs) for Bone Fracture Repair: Past and Perspective Findings. Annals of Biomedical Engineering. 2018. V. 46. P. 525–542. https://doi.org/10.1007/s10439018-1982-1
- Greenbaum B., Goodman E.M., Fredrickson J. Effects of pulsed electromagnetic fields on cell migration in cultured confluent endothelial cells. Annu Int. Conf. IEEE Eng. Med. Biol. Soc. 1991 V. 13. P. 1024–1026.
- Aaron R.K., Boyan B.D., Ciombor D.M., Schwartz Z., Simon B.J. Stimulation of growth factor synthesis by electric and electromagnetic fields. Clin. Orthop. Relat. 2010. Res. 419. P. 30–37.
- Martino C.F., Perea H., Hopfner U., Ferguson V.L., Wintermantel E. Effects of weak static magnetic fields on endothelial cells. Bioelectromagnetics. 2010 V. 31. P. 296-301. DOI: 10.1002/bem.20565
- Förstermann U., Sessa W.C. Nitric oxide synthases: regulation and function. European Heart Journal. 2012. V. 33. Iss. 7. P. 829–837. https://doi.org/10.1093/eurheartj/ehr304
- Ulashchik V.S. i dr. Magnitoterapiya: teoreticheskiye osnovy i prakticheskoye primeneniye. Pod obshch. red. V.S. Ulashchika. Minsk: Belaruskaya navuka. 2015. 379 s (in Russian).
- SanPiN 2.2.4.3359-16 Sanitarno-epidemiologicheskie trebovaniya k fizicheskim faktoram na rabochikh mestakh (razdel 7 “Elektricheskie, magnitnye, elektromagnitnye polya na rabochikh mestakh”) (in Russian).
- Cornell University, USA (Ithaca, NY): “Magnetic field safety guide. Environmental health and Safety”, section 5.2 Magnetic field safety guide. Environmental health and Safety http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.675.1271&rep=rep1&type=pdf
- Gurfinkel Yu.I., Ozheredov V.A., Breus T.K., Sasonko M.L. The Effects of Space and Terrestrial Weather Factors on Arterial Stiffness and Endothelial Function in Humans. Biophysics. 2018. V. 63. № 2. Р. 402–411.
- Bouïs D., Hospers G.A., Meijer C. et al. Endothelium in vitro: A review of human vascular endothelial cell lines for blood vessel-related research. Angiogenesis. 2001. V. 4. P. 91. https://doi.org/10.1023/A:1012259529167
- Celermajer D.S., Sorensen K.E., Gooch V.M., Spiegelhalter D.J., Miller O.I., Sullivan I.D., Lloyd J.K., Deanfield J.E. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992. V. 340 (8828). P. 1111–1115.
- Varga Z., Flammer A.J., Steiger P., Haberecker M. Endothelial cell infection and endotheliitis in COVID-19. Rea Andermatt, Annelies S Zinkernagel, Mandeep R Mehra, Reto A Schuepbach, Frank Ruschitzka, Holger Moch. The Lancet Journal. 2020. V. 395. Iss. 10234. P. 1417–1418. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30937-5/fulltext#%20